ETHYL PICOLINATE

PRODUCT IDENTIFICATION

CAS NO. 2524-52-9

ETHYL PICOLINATE

EINECS NO. 219-758-0
FORMULA C8H9NO2
MOL WT. 151.16

HS CODE

2933.39

TOXICITY

 
SYNONYMS 2-Pyridinecarboxylic acid, ethyl ester;
Ethyl pyridine-2-carboxylate; Ethyl-2-picolinate; Ethylpyridin-2-carboxylat (German); Piridina-2-carboxilato de etilo (Spanish); Pyridine-2-carboxylate d'éthyle (French);
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE clear to slightly yellow liquid
MELTING POINT 2 C
BOILING POINT 240 - 241 C
SPECIFIC GRAVITY 1.119
SOLUBILITY IN WATER miscible
pH  
VAPOR DENSITY 5.21

NFPA RATINGS

Health: 1; Flammability: 1; Reactivity: 0 

AUTOIGNITION

 

REFRACTIVE INDEX

1.511

FLASH POINT

107 C

STABILITY Stable under normal conditions.

APPLICATIONS

Picolinic acid, an isomer of nicotinic acid, is a six-membered ring structure compound composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring, plus a carboxyl side chain at 2-position (nicotinic acid has a carboxyl side chain at 3-position). It acts as a chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the body. It is involved in phenylalanine, tryptophan, and alkaloids production, and for the quantitative detection of calcium. This forms a complex with zinc, may facilitate the passage of zinc through the gastrointestinal wall and into the circulatory system. Commercially picolinic acid is used as an intermediate to produce pharmaceuticals (especially local anesthetics) and metal salts for the application of nutritional supplements. Its esters are used in manufacturing pharmaceuticals and pesticides.
SALES SPECIFICATION
APPEARANCE clear to slightly yellow liquid

ASSAY

99.0% max
LOSS ON DRYING 0.5% max
TRANSPORTATION
PACKING 200kgs in drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION

Hazard Symbols: , Risk Phrases: 36/37/38, Safety Phrases: 24/25-28A-37-45

GENERAL DESCRIPTION  OF PYRIDINE

PYRIDINE, also called azabenzene and azine, is a heterocyclic aromatic tertiary amine characterized by a six-membered ring structure composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring (C5H5N). The simplest member of the pyridine family is pyridine itself. It is colorless, flammable, toxic liquid with a unpleasant odor, miscible with water and with most organic solvents, boils at 115 C. Its aqueous solution is slightly alkaline. Its conjugate acid is called pyridinium cation, C5H5NH+, used as a oxidation agent for organic synthesis.. Pyridine is a base with chemical properties similar to tertiary amines. Nitrogen in the ring system has an equatorial lone pair of electrons, that does not participate in the aromatic pi-bond. Its aqueous solution is slightly alkaline. It is incompatible and reactive with strong oxidizers and strong acids, and reacts violently with chlorosulfonic acid, maleic anhydride, oleum, perchromates, b-propiolactone, formamide, chromium trioxide, and sulfuric acid. Liquid pyridine easily evaporates into the air. If it is released to the air, it may take several months to years until it breaks down into other compounds. Usually, pyridine is derived from coal tar or synthesized from other chemicals, mainly acetaldehyde and ammonia. Pyridine compounds are found in nature. For example, nicotine from tobacco, ricinine from castor bean, pyridoxine or vitamin B and P products, alkaloids (such as coniine, piperine and nicotine), and etc. Some pyridine compounds consumed largely are;

Picoline : Three structural isomers of methyl pyridines (alpha, beta, gamma- positions)
Lutidine : Six structural isomers of dimethyl pyridines (2,3-, ,24-, 2,5-, 2,6-, 3,4-, 3,5- positions)
Collidine : Three structural isomers of trimethyl pyridines (2,3,5-, 2,3,6-, 2,4,6- positions)
Pyrimidine: Pyridine alteration containing nitrogen atoms at positions 1 and 3
Piperidine: Hexahydropyridine (saturated form)
Nicotinic acid: pyridine-3-carboxylic acid

Pyridine and its derivatives are very important in industrial field as well as in bio chemistry. Nucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine). Three major pyrimidines in living systems are cytosine, thymine, and uracil. Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. Some pyridine system is active in the metabolism in the body. Certain nitrogenous plant products also have pyridine class compounds. They can be the parent compound of many drugs, including the barbiturates. Pyridine and its derivatives are used as solvents and starting material for the synthesis of target compounds such as insecticides, herbicides, medicines, vitamins, food flavorings, feed additives, dyes, rubber chemicals, explosives, disinfectants, and adhesives. Pyridine is also used as a denaturant for antifreeze mixtures, as a dyeing assistant in textiles and in fungicides.