ESMOLOL HYDROCHLORIDE

ESMOLOL HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO.

81147-92-4; 84057-94-3; 103598-03-4 (Base)
81161-17-3 (Hydrochloride)

ESMOLOL HYDROCHLORIDE

EINECS NO.

FORMULA C₁₆H₂₅NO₄·HCl

MOL WT. 331.8

H.S. CODE

TOXICITY

SYNONYMS Brevibloc; Esmolol HCl;

(±)-Methyl-p-[2-hydroxy- 3-(isopropylamino)propoxy] hydrocinnamate; 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenylpropionic acid, methyl ester; Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate;

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY Stable under ordinary conditions.

APPLICATIONS

Esmolol is a short-term (half-life: apprx. 9 minutes) cardioselective beta1-blocking agent used as an antiarrhythmic in the control of atrial fibrillation, atrial flutter, and noncompensatory sinus tachycardia. Its chemical designation is (±)-Methyl-p-[2-hydroxy- 3-(isopropylamino)propoxy] hydrocinnamate; existing enantiomeric pair. The hydrochloride salt of esmolol a white to off-white crystalline powder; soluble in water and alcohol; administered by intravenous infusion; administered by intravenous infusion.

SALES SPECIFICATION (USP24)

APPEARANCE

white to off-white crystalline powder

ASSAY

98.5% - 101.5%

WATER

2.0% max

INDIVIDUAL IMPURITY

0.2% max (TOTAL 0.5% max)

SOLVENT RESIDUE

0.1% max

HEAVY METALS

20ppm max

TRANSPORTATION

PACKING

HAZARD CLASS 6 (Packing Group: III)

UN NO. 2811

OTHER INFORMATION

Hazard Symbols: T, Risk Phrases: 23/24/25, Safety Phrases: 36/37/39-45
PRICE INFORMATION