DOXYCYCLINE HYCLATE

PRODUCT IDENTIFICATION

CAS NO. 564-25-0 (Base)
24390-14-5 (
hyclate)
17086-28-1(
monohydrate)
94088-85-4 (calcium)

DOXYCYCLINE

EINECS NO. 209-271-1
FORMULA C22H24N2O8·HCl·1/2(H2O)·1/2(C2H6O)
MOL WT. 512.94

H.S. CODE

 

TOXICITY

 
SYNONYMS Doxycycline hydrochloride hemiethanolate hemihydrate;
4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo-2-naphthacenecarboxamide;

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellowish crystalline powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER soluble
pH 2 - 3
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

Health: 1 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION AND APPLICATIONS

Doxycycline is a semisynthetic broad-spectrum antibiotic or antibacterial belongs to the tetracycline family. It is used treat urinary tract infections, gum disease, and bacterial infections such as gonorrhea, chlamydia and Bacillus anthracis. It is also used to treat acne. Doxycycline is available in complex salt of hydrochloride, hemiethanolate, and hemihydratehyclate for oral administration and for intravenous use. Doxycycline hyclate is a yellowish crystalline powder; soluble in water. Doxycycline will not degrade into an epianhydro form. The chemcial designation is 4-(Dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methyl-1, 11-dioxo-2-naphthacenecarboxamide Tetracyclines inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit. They acts as growth inhibitors (bacteriostatic) rather than killer of the infectious agent (bacteriocidal) and are only effective against multiplying microorganisms.

Tetracycline antibiotics include;

  • Chlortetracycline (CAS # : 57-62-5)
  • Demeclocycline Hydrochloride (CAS # : 64-73-3)
  • Demethylchlortetracycline (CAS # : 127-33-3)
  • Dihydrostreptomycin Sesquisulfate (CAS # : 5490-27-7)
  • Doxycycline (CAS # : 564-25-0)
  • Duramycin (CAS # : 1391-36-2)
  • Meclocycline Sulfosalicylate (CAS # : 73816-42-9)
  • Methacycline Hydrochloride (CAS # : 3963-95-9)
  • Minocycline (CAS # : 10118-90-8)
  • Neomycin (CAS # : 1404-04-2)
  • Oxytetracycline (CAS # : 6153-64-6)
  • Streptomycin (CAS # : 57-92-1)
  • Tetracycline (CAS # : 60-54-8)
  • Vancomycin (CAS # : 123409-00-7)
SALES SPECIFICATION (BP2000)

APPEARANCE

yellowish crystalline powder
ASSAY

99.0% min

pH

2 - 3

OPTICAL ROTATION

-105° ~ -120°

ETHANOL

4.5 - 6.0%

WATER

1.4 - 2.8%

HEAVY METALS

20ppm max

ASH

0.5% max

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26
PRICE INFORMATION
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