DIPICOLINIC ACID

PRODUCT IDENTIFICATION

CAS NO. 499-83-2

DIPICOLINIC ACID

EINECS NO. 207-894-3
FORMULA (C5H3N)(COOH)2
MOL WT. 167.12

HS CODE

2933.39

TOXICITY

 
SYNONYMS Pyridine-2,6-dicarboxylic acid;
Pyridin-2,6-dicarbonsäure (German); 2,6-Pyridinedicarboxylic acid; ácido piridina-2,6-dicarboxílico (Spanish); Acide pyridine-2,6-dicarboxylique (French);
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT 248 - 250 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY  

NFPA RATINGS

Health: 1; Flammability: 0; Reactivity: 0 

AUTOIGNITION

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under normal conditions.

APPLICATIONS

Pyridinecarboxylic acids are active in the metabolism of body. For example, nicotinic acid (3-pyridinecarboxylic acid) is is a constituent of the redox coenzymes nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate which are essential in energy metabolism in the living cell. Pyridinecarboxylic acids act as chelating agents of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the body. They are involved in phenylalanine, tryptophan, and alkaloids production, and for the quantitative detection of calcium. This forms a complex with zinc, may facilitate the passage of zinc through the gastrointestinal wall and into the circulatory system. Nicotinic acid reacts with hemoglobin and myoglobin,  which provide an application in meat processing to form brighter colour. It acts to reduce plasma cholesterol, as a vasodilator and to treat pellagra.  It is used for the prophylaxis. Pyridinecarboxylic acids  and their derivatives can be studied for these effects. They used as intermediate to produce pharmaceuticals and metal salts for the application of nutritional supplements. Quinolinic acid inhibits glucose synthesis. Fusaric acid (butyl ester of picolinic acid) inhibits dopamine beta-hydroxylase activity.
  • Nicotinic acid (Niacin; 3-Pyridinecarboxylic acid, CAS #: 59-67-6)
  • Isonicotinic acid (4-Pyridinecarboxylic acid, CAS# : 55-22-1)
  • Picolinic acid (2-Pyridinecarboxylic acid; 98-98-6)
  • Fusaric acid (5-Butyl-2-pyridinecarboxylic acid, 536-69-6)
  • Dinicotinic acid (3,5-Pyridinedicarboxylic acid, 499-81-0)
  • Dipicolinic acid (2,6-Pyridinedicarboxylic acid, 499-83-2)
  • Quinolinic acid (2,3-Pyridinedicarboxylic acid, 89-00-9)
  • Lutidinic acid (2,4-Pyridinedicarboxylic acid, 499-80-9)
  • Cinchomeronic acid (3,4-Pyridinedicarboxylic acid, 490-11-9)
  • Isocinchomeronic acid (2,5-Pyridinedicarboxylic acid, 100-26-5)
SALES SPECIFICATION
APPEARANCE white powder

ASSAY

99.0% max
LOSS ON DRYING 0.5% max
TRANSPORTATION
PACKING 25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION

Hazard Symbols: , Risk Phrases: 36/37/38, Safety Phrases: 24/25-28A-37-45

GENERAL DESCRIPTION OF PYRIDINE

PYRIDINE, also called azabenzene and azine, is a heterocyclic aromatic tertiary amine characterized by a six-membered ring structure composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring (C5H5N). The simplest member of the pyridine family is pyridine itself. It is colorless, flammable, toxic liquid with a unpleasant odor, miscible with water and with most organic solvents, boils at 115 C. Its aqueous solution is slightly alkaline. Its conjugate acid is called pyridinium cation, C5H5NH+, used as a oxidation agent for organic synthesis.. Pyridine is a base with chemical properties similar to tertiary amines. Nitrogen in the ring system has an equatorial lone pair of electrons, that does not participate in the aromatic pi-bond. Its aqueous solution is slightly alkaline. It is incompatible and reactive with strong oxidizers and strong acids, and reacts violently with chlorosulfonic acid, maleic anhydride, oleum, perchromates, b-propiolactone, formamide, chromium trioxide, and sulfuric acid. Liquid pyridine easily evaporates into the air. If it is released to the air, it may take several months to years until it breaks down into other compounds. Usually, pyridine is derived from coal tar or synthesized from other chemicals, mainly acetaldehyde and ammonia. Pyridine compounds are found in nature. For example, nicotine from tobacco, ricinine from castor bean, pyridoxine or vitamin B and P products, alkaloids (such as coniine, piperine and nicotine), and etc. Some pyridine compounds consumed largely are;

Picoline : Three structural isomers of methyl pyridines (alpha, beta, gamma- positions)
Lutidine : Six structural isomers of dimethyl pyridines (2,3-, ,24-, 2,5-, 2,6-, 3,4-, 3,5- positions)
Collidine : Three structural isomers of trimethyl pyridines (2,3,5-, 2,3,6-, 2,4,6- positions)
Pyrimidine: Pyridine alteration containing nitrogen atoms at positions 1 and 3
Piperidine: Hexahydropyridine (saturated form)
Nicotinic acid: pyridine-3-carboxylic acid

Pyridine and its derivatives are very important in industrial field as well as in bio chemistry. Nucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine). Three major pyrimidines in living systems are cytosine, thymine, and uracil. Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. Some pyridine system is active in the metabolism in the body. Certain nitrogenous plant products also have pyridine class compounds. They can be the parent compound of many drugs, including the barbiturates. Pyridine and its derivatives are used as solvents and starting material for the synthesis of target compounds such as insecticides, herbicides, medicines, vitamins, food flavorings, feed additives, dyes, rubber chemicals, explosives, disinfectants, and adhesives. Pyridine is also used as a denaturant for antifreeze mixtures, as a dyeing assistant in textiles and in fungicides.