DICLOXACILLIN SODIUM

DICLOXACILLIN SODIUM
PRODUCT IDENTIFICATION
CAS NO.	3116-76-5 (Base), 13412-64-1 (Sodium)
EINECS NO.	226-051-0, 217-428-0
FORMULA	C₁₉H₁₆N₃Cl₂O₅S·Na·H₂O
MOL WT.	510.32
H.S. CODE	2941.10.3000
TOXICITY
SYNONYMS	Dicloxacillin sodium; Dycil; Dynapen; Pathocil;
[2S (2a, 5a, 6b)]-3.3-Dimethyl-6-[[3-(2-chloro-6-chlorophenyl)-5-methyl-3-phenyl-4-isoxazolyl) carbonyl] amino]-7-oxo-4-thia-1- azabicyclo [3.2.0]heptane-2-carboxylic acid monosodium salt; 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl penicillin sodium monohydrate; Monosodium (2S,5R,6R) -6- (3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxamido) -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo (3.2.0)heptane-2-carboxylate monohydrate; Stampen; Staphcillin A banyu;
SMILES	[Na+].N12[C@@H]([C@@H](NC(c3c(c4c(cccc4Cl)Cl)noc3 C)=O)C2=O)SC (C)(C)[C@@H]1C(=O)[O-].O
CLASSIFICATION	beta-Lactam antibiotic, Isoxazole
EXTRA NOTES	One of the PENICILLINS which is resistant to PENICILLINASE. [MeSH]
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Soluble
pH	5.0 - 7.0
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health hazard: 2, Fire: 0, Reactivity Hazard: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions
EXTERNAL LINKS & GENERAL DESCRIPTION
USA.gov - Dicloxacillin sodium Wikipedia Linking - Dicloxacillin Google Scholar Search - Dicloxacillin sodium U.S. National Library of Medicine - Dicloxacillin sodium PubChem Compound Summary - Dicloxacillin sodium Drug Bank - Dicloxacillin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Dicloxacillin sodium ChEBI (http://www.ebi.ac.uk/chebi/) - Dicloxacillin sodium NCBI (http://www.ncbi.nlm.nih.gov/) - Dicloxacillin sodium EPA - Substance Registry Services - Dicloxacillin sodium http://www.sigmaaldrich.com Biochem/physiol Actions: Docloxacillin binds to specific penicillin-binding proteins (PBPs) in the bacterial cell wall and therefore inhibits the last stage of bacterial cell wall synthesis. Cell lysis, mediated by bacterial cell wall autolytic enzymes, is the result. Dicloxacillin may interfere with autolysin inhibitors. Local: Some organisms are penicillin-resistant because they produce an enzyme called penicillinase, that destroys the antibiotic. Dicloxacillin, an analogue of oxacillin, is a semisynthetic penicillinase-resistant penicillin against staphylococci primarily. New penicillins such as methicillin, (di)cloxacillin, flucloxacillin and oxacillin are not destroyed by the penicillinase, but have no effect on bacteria that are resistant by other means like by altered cell wall structure. Macrolide antibiotics that inhibits protein synthesis by bacteria have become important in treating penicillin-resistant infections in patients allergic to penicillin. The sodium salt of dicloxacillin is administered orally, intramuscularly, or intravenously. Chemical designation is [2S (2a, 5a, 6b)]-3.3-dimethyl-6-[[3-(2-chloro-6-chlorophenyl)-5-methyl-3-phenyl-4-isoxazolyl) carbonyl] amino]-7-oxo-4-thia-1- azabicyclo [3.2.0]heptane-2-carboxylic acid, monosodium salt.
SALES SPECIFICATION
APPEARANCE	white to off white free flowing crystalline powder
IDENTIFICATION	Complies
ASSAY	95.0 - 101.0 % (HPLC)
POTENCY	950 - 1010 units/mg
OPTICAL ROTATION	+128° ~ +142°
RELATED SUBSTANCE	1.0% max (Individual), 5.0% max (total)
WATER	3.5 - 4.5%
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
HAZARD OVERVIEW	GHS (Globally Harmonised System) Classification: Acute toxicity, (Oral). Skin irritation. Eye irritation. Respiratory sensitization. Specific target organ toxicity - single exposure. Hazard statements: May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
GHS
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H315-H319-H334-H335
P STATEMENTS	P261-P305 + P351 + P338-P342 + P311
EC DIRECTIVES
HAZARD CODES
RISK PHRASES	36/37/38-42/43
SAFETY PHRASES	22-26-36/37-45
PRICE INFORMATION