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| CYTARABINE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 147-94-4 |
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| EINECS NO. | 205-705-9 | |
| FORMULA | C9H13N3O5 | |
| MOL WT. | 243.22 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | 1-Beta-D-arabinofuranosylcytosine; Udicil; | |
| 1-beta-D-arabinosyl-4-amino-2(1H)pyrimidinone; Erpalfa; Tarabine; | ||
| 1-beta-D-arabinosylcytosine; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; Arabinocytidine; arabinosylcytosine; Arabitin; Ara-C; Aracytidine; Aracytine; cytosine beta-D-arabinoside; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; Beta-cytosine arabinoside; beta-D-arabinosylcytosine; Cytosine-beta-D-arabinofuranoside; Cytosine arabinoside; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE |
white to off-white crystalline powder |
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| MELTING POINT | 212 - 213 C | |
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Soluble | |
| pH | ||
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| AUTOIGNITION |
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REFRACTIVE INDEX |
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| FLASH POINT | ||
| STABILITY |
Stable under ordinary conditions. |
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GENERAL DESCRIPTION & APPLICATIONS |
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| Cytarabine, cytosine arabinoside, is a synthetic nucleoside which differs from cytidine and deoxycytidine in that the sugar moiety is arabinose rather than ribose on deoxyribose. It is metabolically activated to the triphosphate nucleotide (ara-CTP) which acts as an inhibitor of DNA polymerase and produces S phase–specific cytotoxicity. It is used as an antineoplastic in the treatment of acute lymphocytic, acute myelogenous leukemia, the blast phase of chronic myelogenous leukemia, erythroleukemia, non-Hodgkin's lymphomais, prophylaxis, and meningeal leukemia. Cyclocytidine is metabolized to cytarabine and thereby maintains a more constant antineoplastic action. Cytarabine (1-beta-D-Arabinofuranosylcytosine) is a white to off-white, crystalline powder; freely soluble in water, slightly soluble in alcohol and in chloroform, insoluble in ether. It also has antiviral and immunosuppressant properties. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
fine off-white crystalline powder |
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IDENTIFICATION |
Complies Test A,B |
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| PURITY |
98.0 - 102.0 % |
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SPECIFIC ROTATION |
+156° ~ +160° (C=1 in water) |
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HEAVY METALS |
10ppm max |
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LOSS ON DRYING |
1.0% max |
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RESIDUE ON IGNITION |
0.5% max | |
| TRANSPORTATION | ||
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| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: XN, Risk Phrases: 43-63, Safety Phrases: 36/37 | ||
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