CHOLIC ACID

PRODUCT IDENTIFICATION

CAS NO. 81-25-4

CHOLIC ACID

EINECS NO.

201-337-8

FORMULA C24H40O5
MOL WT. 408.58

H.S. CODE

TOXICITY

SYNONYMS Cholanic acid
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid; (3alpha,5beta,7alpha,12alpha)- 3,7,12- Trihydroxy-, Cholan-24-oic acid; (+)-Cholic acid;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT 200 - 201 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Bile is a bitter, yellow to greenish fluid composed of glycine or taurine conjugated bile salts, cholesterol, phospholipid, bilirubin diglucuronide, and electrolytes. It is secreted by the liver and delivered to the duodenum to aid the process of digestion and fat absorption by emulsification of fat products in the upper small intestine. They play role dissolving cholesterol and accretes into lumps in the gall bladder, forming gallstones. Bile's bicarbonate constituents serves for alkalinizing the intestinal contents. Bile is responsible for as the route of excretion for hemoglobin breakdown products (bilirubin). Excretion of bile salts by liver cells and secretion of bicarbonate rich fluid by ductular cells in response to secretin are the major factors which normally determine the volume of secretion. Bile acids are liver-generated steroid carboxylic acids. The primary bile acids (cholic and chenodeoxycholic acid) are conjugated with either glycine or taurine in the form of taurocholic acid and glycocholic acid. The secondary bile acids (deoxycholic, lithocholic, and ursodeoxycholic acid) are formed from the primary bile acids by the action of intestinal bacteria. They are soluble in alcohol and acetic acid. The lithocolyl conjugates are relatively insoluble; excreted mostly in the form of sulfate esters like sulfolithocholylglycine. Most of the bile acids are reabsorbed and returned to the liver via enterohepatic circulation, where, after free acids are reconjugated, they are again excreted. 
  • Cholic Acid
  • Methyl Cholate
  • Deoxycholic Acid
  • Dehydrocholic Acid
  • Methyl Deoxycholate
  • Chenodeoxycholic Acid
  • Methyl Chenodeoxycholate
  • Sodium Glycocholate
  • Glycodeoxycholic Acid
  • Sodium Glycodeoxycholate
  • Sodium Taurocholate
  • Sodium Taurodeoxycholate
  • Ursodeoxycholic acid
 

Commecial bile acids' application fields include:

  • Experimental basis of cathartics, cholagogues
  • Preventing and dissolving gallstones.
  • As an intermediate for the production of corticosteroid structure drugs to treat various disorders such as pain or inflammation, brain tumors, skin diseases, and allergic reactions.
  • As detergents to emulsify biological fats.
  • Vaccine delivery system

EXAMPLES OF NATURALLY OCCURRING CARBOXYLIC ACIDS
(excluding fatty acids)

Pyruvic acid

Lactic Acid

Cholic acid

Nicotinic acid

PYRUVIC ACID

Lactic Acid

cholic acid

Nicotinic acid

metabolic intermediate

metabolic intermediate

from bile

vitamin B

 

Citric acid

Malic Acid

Biotin

Abietic acid

Citric acid

Malic Acid

Biotin

Abietic acid

in plants

in fruits

cell growth factor

pine rosin

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

98.0% min

OPTICAL ROTATION +34° ~ +38° (0.6 in EtOH)
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN , Risk Phrases: 63, Safety Phrases: 22-24/25