CEPHALEXIN MONOHYDRATE

CEFALEXIN MONOHYDRATE

GENERAL

Cefalexin is a semisynthetic 1st generation cephalosporin antibiotic Inhibiting cell wall biosynthesis. It is used especially in the treatment of respiratory and urinary tract infections and is intended for oral administration. Cephalosporins differ from penicillins in the structure of the bicyclic ring system. Cefalexin has an unsubstituted methyl group at the 3-position and a D-phenylglycyl group as substituent at the 7-amino position. It's chemical name is 7-(D-alpha-Amino-alpha-phenyl acetamido)- 3-methyl-3-cephem- 4-carboxylic acid. Commercial cefalexin is available in a monohydrate form which is a white crystalline powder with a bitter taste and low solubility in water.

STRUCTURE

CAS NO.

CEPHALEXIN

23325-78-2

ACTIVITY

ANTIBOITICS / CEPHALOSPORINS /

MOL WT.

C₁₆H₁₇N₃O₄S, H₂O
365.40

SYNONYMS

Cefanex, C-Lexin, Keflet, Keflex, Keftab, Cefalexin, Ibilex

SPECIFICATION & DESCRIPTION

PROPERTY		VALUE
Bibliography		BP USP
Appearance		White or Almost White Powder
Identification		Comply Test
Assay		98.0 - 100.5 % (on Anhydrous basis)
Clarity of Solution		Complies test
Spec. Optical Rotation		+149° - +158°
Light absorption (400nm)		0.2% max
Heavy Metals		20 ppm max
N,N-Dimethylaniline		20 ppm max
Sulfated Ash		0.5% max
Water		4.0% - 8.0%
pH		4.0 - 5.5
Releted Substance	7-ADCA	1.0% max
	DL-Phenylglycine	1.0% max

COMMENTS

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