CEFALEXIN MONOHYDRATE

GENERAL
Cefalexin is a semisynthetic 1st generation cephalosporin antibiotic Inhibiting cell wall biosynthesis. It is used especially in the treatment of respiratory and urinary tract infections and is intended for oral administration. Cephalosporins differ from penicillins in the structure of the bicyclic ring system. Cefalexin has an unsubstituted methyl group at the 3-position and a D-phenylglycyl group as substituent at the 7-amino position. It's chemical name is 7-(D-alpha-Amino-alpha-phenyl acetamido)- 3-methyl-3-cephem- 4-carboxylic acid. Commercial cefalexin is available in a monohydrate form which is a white crystalline powder with a bitter taste and low solubility in water.

STRUCTURE

CAS NO.

 CEPHALEXIN

23325-78-2

ACTIVITY

ANTIBOITICS / CEPHALOSPORINS /

MOL WT.

C16H17N3O4S, H2O
365.40
SYNONYMS
Cefanex, C-Lexin, Keflet, Keflex, Keftab, Cefalexin, Ibilex

SPECIFICATION & DESCRIPTION

PROPERTY

VALUE

Bibliography

BP USP

Appearance

White or Almost White Powder

Identification

Comply Test

Assay

98.0 - 100.5 % (on Anhydrous basis)

Clarity of Solution

Complies test

Spec. Optical Rotation

+149° - +158°

Light absorption (400nm)

0.2% max

Heavy Metals

20 ppm max

N,N-Dimethylaniline

20 ppm max

Sulfated Ash

0.5% max

Water

4.0% - 8.0%

pH

4.0 - 5.5

Releted Substance

7-ADCA

1.0% max

DL-Phenylglycine

1.0% max

COMMENTS
Packing : 25kgs in Fiber Drum