CEFTAZIDIME PENTAHYDRATE

PRODUCT IDENTIFICATION
CAS NO. 72558-82-8 (Base)
78439-06-2 (Pentahydrate)

CEFTAZIDIME

EINECS NO. 276-715-9
FORMULA C22H22N6O7S2· 5H2O
MOL WT. 636.65

H.S. CODE

TOXICITY
SYNONYMS Ceftazidima; CAZ pentahydrate;
1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl] methyl] pyridinum, hydroxide, inner salt, pentahydrate;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE White to off-white powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH  
VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX
FLASH POINT

STABILITY Stable under ordinary conditions.

APPLICATIONS
Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium  and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. Third-generation cephalosporins are more active against gram-negative organisms but less active against gram-positive organisms than second-generation agents; examples are cefoperazone, cefotaxime, ceftriaxone, ceftazidime, ceftizoxime, and moxalactam.
SALES SPECIFICATION

APPEARANCE

 White to off-white powder

ASSAY

 90.0 - 102.0% (on anhydrous basis)
WATER (K.F.) 13.5% max
SOLUTION CLARITY clear, transparent
STERILITY sterile

pH

 5.0 - 7.5

HEAVY METALS

20ppm max

INDIVIDUAL IMPURITY

 0.5% max
TRANSPORTATION
PACKING

5kgs - 20kgs

HAZARD CLASS
UN NO.
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 42/43, Safety Phrases: 22-36/37-45