| CAS
NO. |
41575-94-4 |
|
| EINECS
NO. |
255-446-0 |
| FORMULA |
C6H12N2O4Pt |
| MOL
WT. |
371.25 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
1,1-Cyclobutanedicarboxylatodiammine
Platinum (II); |
| 1,1-Cyclobutanedicarboxylate diamine platinum(II);
Paraplatin; cis-(1,1-Cyclobutane dicarboxylato) diamineplatinum(II);
cis-Diamine (1,1-cyclobutaned icarboxylato) platinum(II);
(SP-4-2)-
diamine (1,1-cyclobutanedicarboxylato (2-)-O,O')-platinum (II); |
|
DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
crystalline powder |
| MELTING
POINT |
|
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
Soluble |
| pH |
|
| VAPOR
DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
| Carboplatin, a platinum coordination compound which contains a platinum atom
surrounded with two ammonia groups and two other ligands in a ring structure.
Cisplatin is an analogue which has two chloride atoms instead of ring structure.
Oxaliplatin contains a platinum atom complexed with 1,2-diaminocyclohexane and with an oxalate ligand as a leaving
group. It is known that diaminocyclohexane group contributes
greater cytotoxicity than cisplatin and carboplatin. Oxaliplatin is not
generally cross-resistant to cisplatin or carboplatin. They are capable of forming platinum complexes producing inter- and intrastrand
DNA crosslinks with neighboring guanine residues, resulting in DNA-mismatch
repair (MMR) activity in the cancer cells. Carboplatin has less nephrotoxicity,
neurotoxicity, ototoxicity and emetogenesis and more stability than cisplatin. They,
platinum-based antineoplastics, have a broad spectrum of antitumor activity
in the treatments of carcinomas of ovarian, testicular, bladder, small and non–small cell
lung, head and neck carcinoma, and seminoma. They are synergistic with fluorouracil. They
are radiation
sensitive. The chemical designation of
cisplatin is
(SP-4-2)-diaminedichloroplatinum (II). It is a yellow crystalline powder; soluble in water
and saline; administered intravenously.
The chemical designation of
carboplatin is (SP-4-2)-diammine [1,1-cyclobutanedicarboxylato (2-)-0,
0']- platinum (II). It is a white crystalline powder; soluble in water; insoluble
in ethanol, acetone, and dimethylacetamide; administered intravenously. The chemical designation of oxaliplatin is
SP-4-2-(1R-trans))- (1,2-cyclohexanediamine-N,N')- (ethanedioato(2-)-O,O') platinum
(II). It is a white crystalline powder; soluble in water; very slightly soluble in
methanol; insoluble in ethanol, hexane, benzene and acetone. |
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
crystalline powder |
|
IDENTIFICATION
|
Complies
Test A,B
|
|
ASSAY
|
98.0
- 102.0% (HPLC)
|
|
PLATINUM CONTENT |
52.0
- 53.0%
|
|
RELATED
SUBSTANCE
|
0.5%
max (1,1-Cyclobutane dicarboxylic acid)
|
|
WATER
|
0.5%
max
|
|
INSOLUBLES
IN WATER
|
0.5%
max
|
|
pH
|
5.0
- 7.0 (10mg/ml in water)
|
|
CLARITY
|
Complies
|
|
SILVER
|
10ppm
max |
| BARIUM |
10ppm
max |
| TRANSPORTATION |
| PACKING |
|
| HAZARD
CLASS |
6.1
(Packing Group:III) |
| UN
NO. |
2811 |
| OTHER
INFORMATION |
| Hazard Symbols: T , Risk Phrases: 46-61-20/21/22-42/43,
Safety Phrases: 53-22-26-36/37/39-45 |
| GENERAL
DESCRIPTION OF ALKYLATING AGENTS
AS ANTITUMOR
|
Alkylating agents are used in cancer chemotherapy by the substitutiopn of alkyl
groups for the hydrogen atoms in biological organic compounds present in cells
to inhibit tumor growth with mutagenic activity. They cross-links DNA, makes the
strands unable to seperate, and induces mutations. They are cell cycle
non-specific drugs. Their effects primarily occurs in proliferating tissues
which don't have time to mitose DNA repair systems. Classes of alkylating agents
for antineoplastic include:
- Nitrogen mustard
- Chlorambucil (CAS
RN:
305-03-3)
- Mechlorethamine (CAS
RN:
51-75-2)
- Melphalan (CAS
RN:
148-82-3)
- Uracil Mustard
(CAS RN:
66-75-1)
- Cyclophosphamide (CAS
RN:
50-18-0)
- Iphosphamide (CAS
RN:
3778-73-2)
- Nitrosoureas
- Triethylenemelamine
(CAS RN:
51-18-3)
- Hexamethylmelamine (CAS
RN:
645-05-6)
- Bis-chloroethylnitrosourea (CAS
RN:
154-93-8)
- Chloroethylcyclohexylnitrosourea (CAS
RN:
13010-47-4)
- Streptozotocin (CAS
RN:
18883-66-4)
- Platinum compounds
- Carboplatin (CAS
RN:
41575-94-4)
- Oxaliplatin
(CAS RN:
61825-94-3)
- Cisplatin (CAS
RN:
15663-27-)
- Tetraplatin
(CAS RN:
62816-98-2)
- (Carboxyphthalato)platinum (CAS
RN:
65296-81-3)
- Alkyl
sulfonates
- Busulfan (CAS
RN:
55-98-1)
- Aziridines
- Thiotepa (CAS
RN:
52-24-4)
|