CALCIUM SENNOSIDE

PRODUCT IDENTIFICATION
CAS NO. 81-27-6 (Sennoside A)
128-57-4 (Sennoside B)
517-43-1, 52730-37-7 (Calcium Salt)

CALCIUM SENNOSIDE
EINECS NO. 201-339-9 (Sennoside A)
204-895-0 (Sennoside B)
208-238-9, 258-141-0 (Calcium Salt)
FORMULA C42H36CaO20
MOL WT. 900.81

H.S. CODE

  

TOXICITY

 
SYNONYMS Sennoside A and B Calcium salts;
5,5'-Bis(beta-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'- bianthracene]-2,2'-dicarboxylic acid calcium salt
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE pale brownish hygroscopic powder
MELTING POINT  
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER Soluble
pH 6.3 - 7.3
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions. Hygroscopic.

GENERAL DESCRIPTION  & APPLICATIONS

Cathartics promote or encourage defecation by accelerating the passage of feces through the large intestine, by influencing the consistency and amount of stool, and by facilitating the elimination of feces from the rectum. The terms laxative and cathartic reflect the typical intensity and latency of effect. A cathartic usually produces prompt fluid evacuation, while a laxative usually produces a soft formed stool over a protracted period. Cathartics or laxatives can be classified as belows:

  • Bulk-forming agents
    • Psyllium
    • Methylcellulose
    • Polycarbophils
  • Osmotics
    • Saline
    • Cleansing laxative
      • Polyethylene glycol
    • Hyperosmolar laxative
      • Lactulose
      • Sorbitol
      • Glycerin suppositories
  • Stimulants
    • Cascara
    • Sennosides
    • Phenolphthalein
    • Bisacodyl
    • Casanthranol
    • Aloe Vera
    • Castor Oil
  • Stool softener
    • Docusate Calcium
    • Docusate Sodium
    • Docusate Potassium
  • Lubricants/Emollients
    • Mineral oils

Sennoside: either hydroxyanthracene glycosides (designated A and B) derived from senna as the calcium salts; pale brownish hygroscopic powder; soluble in water and alcohol. They are used as a cathartic; administered orally. The chemical designation is 5,5'-bis(beta-D-gulcopyranosyloxy)-9,9',10,10'- tetrahydro-4,4'-dihydroxy-10,10'-dioxo [9,9'-bianthracene]-2,2'-dicarboxylic acid calciium salt.

Other sennosides

Sennoside E (or F) [CAS #: 11137-63-6]: (9,9'-Bianthracene)-2,2'-dicarboxylic acid, 5-((O- (carboxycarbonyl)- beta-D-glucopyranosyl)oxy)-5'-(beta-D- glucopyranosyloxy)-9,9',10,10'- tetrahydro-4,4'-dihydroxy- 10,10'-dioxo-, (R',R')-

Sennoside C (or D) [ CAS #: 37271-16-2; 26403-11-2; 28878-51-5]: (9,9'-Bianthracene)-2-carboxylic acid, 5,5'-bis(beta-D- glucopyranosyloxy)- 9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'- (hydroxymethyl)- 10,10'-dioxo-, (R',R')-

Sennoside G [CAS #: 66575-30-2; 73613-07-7]: (9,9'-Bianthracene)-2,2'-dicarboxylic acid, 5,5'-bis(beta-D- glucopyranosyloxy) -9,9',10,10'-tetrahydro-4,4'- dihydroxy- 10,10'-dioxo-, (R',R')- 
SALES SPECIFICATION (STANDARD: BP, USP)

APPEARANCE

 pale brownish powder

IDENTIFICATION

Complies

SENNOSIDES

20% min or , 55 - 65% min or 90.0% min

pH

6.3 - 7.3

HEAVY METALS

10ppm max

WATER

5.% max

TOTAL MICROBIAL

5000 cfu/gr max

E COLI &SALMONELLA

none

MOULD & YEAST

100/gr max
TRANSPORTATION
PACKING

 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 40, Safety Phrases: 22-36

MEMBERS OF CATHARTIC

Product

CAS RN
Sorbitol 50-70-4
Glycerin 56-81-5
Urea 57-13-6
Mannitol 69-65-8
Propane 74-98-6
Phenolphthalein 77-09-8
Sennoside A 81-27-6
Dichlorophen 97-23-4
Oxyphenisatin Acetate 115-33-3
Danthron 117-10-2
Sennoside B 128-57-4
Docusate calcium 128-49-4
Chenodiol 474-25-9
Emodin 518-82-1
Docusate sodium 577-11-7
Lactitol 585-86-4
Dihydroxydiphenyl-pyridyl methane 603-41-8
Bisacodyl 603-50-9
Dihydroxydianthrone 641-12-3
Isosorbide 652-67-5
Magnesia 1309-42-8
Magnesium oxide 1309-48-4
Bisacodyl tannex 1336-29-4
Aloin 1415-73-2
Magnesium citrate 3344-18-1
Lactulose 4618-18-2
Aloe emodin anthrone 6247-99-0
Potassium sodium tartrate 6381-59-5
Magnesium sulfate anhydrous 7487-88-9
Docusate potassium 7491-09-0
Sodium phosphate 7632-05-5
Sodium phosphate, dibasic, heptahydrate 7782-85-6
Castor oil 8001-79-4
Linseed oil 8001-26-1
Mineral Oil 8012-95-1
Senna 8013-11-4
Alloin 8015-61-0
Casanthranol 8024-48-4
Cascara 8047-27-6
Psyllium 8063-16-9
Tragacanth 9000-65-1
Karaya gum 9000-36-6
Calcium polycarbophil 9003-97-8
Poloxalene 9003-11-6
Carboxymethylcellulose sodium 9004-32-4
Methylcellulose 9004-67-5
Magnesium sulfate 10034-99-8
Sodium Picosulfate 10040-45-6
1,4-Bis(2-ethylhexyl) sulfosuccinate 10041-19-7
Sodium phosphate, dibasic 10140-65-5
Sennoside E 11137-63-6
Bisoxatin acetate 14008-48-1
Sodium sulfate anhydrous 15124-09-1
Phenolphthalein glucuronide 15265-26-6
Laxagetten 4,4'-diacetoxydiphenylpyridylemethane 18869-73-3
Normolaxol 19035-45-1

Polyethylene glycol

25322-68-3
4-(alpha-(p-Acetoxyphenyl)-2-picolyl)phenylsulfuric acid sodium salt 36175-10-7
Sennoside C 37271-16-2
Toralactone 41743-74-2
Sennoside A calcium salt 52730-36-6
Sennoside B calcium salt 52730-37-7
Sulisatin 54935-04-5
Prunuside 55835-08-0
Sennoside G 66575-30-2
alpha-Glucomannan 76081-94-2
Cristolax 76282-87-6
Agiolax 76359-32-5
Doxidan 76404-07-4
Alophen 76741-91-8
Ormobyl 76822-81-6
Laxsil 78065-45-9
laxos 78065-46-0
Physcion diglucoside 84268-38-2
Correctol 89066-78-4
Pumosetrag 153062-94-3
Icodextrin 337376-15-5