BROMHEXINE HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO. 611-75-6 (HCl), 3572-43-8 (Parent)

BROMHEXINE HYDROCHLORIDE

EINECS NO. 210-280-8 (HCl), 222-684-1 (Parent)
FORMULA C14H20Br2N2 · HCl
MOL WT. 412.59

H.S. CODE

2921.59.4000

TOXICITY

Oral Rat LD50: 6000mg/kg

SYNONYMS Bromhexine hydrochloride; Auxit; Bisolvon; Bromessina;
2-Amino-N-cyclohexyl-3,5-dibromo-N-methylbenzylamine hydrochloride; Viscolyt; 3,5-Dibromo-Nalpha-cyclohexyl-Nalpha-methyltoluene-alpha, 2-diamine monohydrochloride; Bromhexine HCl; Bromohexine monohydrochloride; Broncokin; N-(2-Amino-3,5-dibromobenzyl)-N- methyl-cyclohexylammonium chloride; N-Cyclohexyl- N-methyl-(2-amino-3,5-dibromobenzyl) ammonium chloride; N-Cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amin HCl;
SMILES c1(c(c(cc(c1)Br)Br)N)CN(C1CCCCC1)C.Cl

CLASSIFICATION

Expectorant, Mucolytic

EXTRA NOTES

A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white crystalline powder

MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER

Very slightly soluble

SOLVENT SOLUBILITY

Slightly soluble in alcohol and methylene chloride

pH  
log P (octanol-water) 4.88
OH RATE CONSTANT 1.13E-10 (cm3/molecule-sec at 25 C Atmospheric)
AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

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Bromhexine Product Information
Pharmacokinetics: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. Its oral bioavailability is stated to be only about 20%. It is widely distributed to body tissues and is highly bound to plasma proteins. About 85 to 90% of a dose is excreted in the urine mainly as metabolites. It has a terminal elimination half-life of up to about 12 hours. Bromhexine crosses the blood brain barrier and small amounts cross the placenta.

Pharmacodynamics/Mechanism of action: Bromhexine is an oral mucolytic agent with a low level of associated toxicity. Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells. Bromhexine disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces a less viscous mucus, which is easier to expectorate.

http://www.healthguidance.org/
Bromhexine hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. This tends to be given to those with respiratory diseases who have difficulty coughing this out otherwise – by breaking it down it becomes smaller and easier to expel and this means they can breathe without their airways being blocked while also providing cough relief. It is preferable to some cough medication as it does not include any sedatives which can otherwise make those using the medication drowsy. At the same time many other cough medicines simply sooth the throat without actually breaking down the phlegm.

Local:

Members of mucolytic agent

Agent

CAS RN

Bromhexine hydrochloride 611-75-6
Acetylcysteine 616-91-1
Carbocysteine 2387-59-9
Bromhexine 3572-43-8
Ambroxol 18683-91-5
Ambroxol hydrochloride 23828-92-4
4-Amino-3-bromo-5-((diethylamino)methyl)benzoic acid ethyl ester HCl 57814-29-6
Domiodol 61869-07-6
SALES SPECIFICATION

APPEARANCE

white crystalline powder

IDENTIFICATION

passes test a,b,c,d,e

ASSAY

98.5% ~ 101.5%

RELATED SUBSTANCES

0.5% max

LOSS ON DRYING

1.0% max

SULPHATED ASH

0.1% max

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: n/a, Risk Phrases: 42/43, Safety Phrases: 22-36/37-45
PRICE INFORMATION