BENZONATATE

PRODUCT IDENTIFICATION
CAS NO. 104-31-4

BENZONATATE
EINECS NO. 203-194-7
FORMULA C30H53NO11
MOL WT. 603.75

H.S. CODE

  

TOXICITY

  
SYNONYMS Benzonatato; Benzonatatum; Benzononantin;
2,5,8,11,14,17,20, 23,26- nonaoxaoctacosan-28-yl-p-(butylamino) Benzoate; Benzononatine; Polyethyleneglycol-p-n-butylaminobenzoate methyl ester; 4-(Butylamino)benzoic acid 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester  p-(n)-Butylaminobenzoesaeure (nonaaethylenglykolmonomethylaether) ester;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE pale yellow oily liquid
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER soluble
pH 6 - 8
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions. Moisture sensitive

GENERAL DESCRIPTION & APPLICATIONS

Benzonatate is used for symptomatic relief of cough. Benzonatate may be effective in suppressing cough in acute respiratory conditions such as pneumonia, bronchitis, pertussis, and the common cold; and in chronic diseases such as pulmonary emphysema, bronchial asthma, tuberculosis, and pulmonary tumor. Benzonatate has been shown to be more effective than codeine in reducing the frequency of experimentally induced cough, and may be effective in providing symptomatic relief in patients with opiate-resistant cough. Because of the drug’s rapid, pronounced local anesthetic effect, benzonatate has been applied locally in the oral cavity in adults by releasing the drug from the liquid-filled capsules (e.g., by chewing or dissolving two 100-mg liquid-filled capsules in the mouth) to provide sufficient oropharyngeal anesthesia for conscious intubation. This method of administration must not be employed when the drug is used as an antitussive because of the risk of potentially life-threatening complications resulting from local effects of the drug on the oropharyngeal tract. (source: http://www.ashp.org/)

Benzonatate is a peripherally acting antitussive that prevents or relieves minor coughing by anesthetizing the stretch receptors in the respiratory passages, lungs, and pleura. The chemical designation is 2,5,8,11,14,17,20, 23,26- nonaoxaoctacosan-28-yl-p-(butylamino) benzoate.

Members of antitussives
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SALES SPECIFICATION

USP

APPEARANCE

 pale yellow oily liquid

IDENTIFICATION

Complies Test A, Test B

ASSAY

95.0% - 105.0%

REFRACTIVE INDEX

1.509 -1.511 at 20 C

WATER

0.3% max

CHLORIDE

0.00-035% max

SULFATE

0.05% max

HEAVY METALS

10ppm max

SOLVENT RESIDUE

2.5% max
TRANSPORTATION
PACKING
30kgs in drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
 

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Antitussive

CAS RN.

Morphine 57-27-2
Diphenhydramine 58-73-1
Pyrilamine maleate 59-33-6
Phenylephrine hydrochloride 61-76-7
Chloroform 67-66-3
Hydromorphone hydrochloride 71-68-1
Oxycodone 76-42-6
Codeine 76-57-3
Ethylmorphine 76-58-4
Methadone 76-99-3

Piperidione

 77-03-2
Caramiphen 77-22-5
Pentoxyverine 77-23-6
Isoaminile 77-51-0
Orphenadrine 83-98-7
Pheniramine 86-21-5
Pyrilamine 91-84-9
Benzonatate 104-31-4
Dihydrocodeine 125-28-0
Hydrocodone 125-29-1

Levomethadone

 125-58-6
Dextromethorphan 125-71-3
Caramiphen hydrochloride 125-85-9
Caramiphen ethanedisulfonate 125-86-0
Noscapine 128-62-1
Narceine 131-28-2
Pheniramine maleate 132-20-7
Hydrocodone bitartrate anhydrous 143-71-5
Diphenhydramine hydrochloride 147-24-0
Phenylpropanolamine hydrochloride 154-41-6
Medazomide 300-22-1
Genkwanin 437-64-9
Homarylamine 451-77-4
Thebacon 466-90-0
Hydromorphone 466-99-9

Normethadone

 467-85-6
Oxeladin 468-61-1
Doxylamine 469-21-6

Dextropropoxyphene

 469-62-5
Piscidic acid 469-65-8
D-Glaucine 475-81-0
Dimethoxanate 477-93-0
Carbinoxamine 486-16-8
Pholcodine 509-67-1
Diphepanol 510-07-6
Chlophedianol hydrochloride 511-13-7
Dimethoxanate hydrochloride 518-63-8
Bromhexine hydrochloride 611-75-6
Acetylcysteine 616-91-1
Chlophedianol 791-35-5
Nicodicodine 808-24-2
Normethadone hydrochloride 847-84-7
Guaiapate 852-42-6
Noscapine hydrochloride 912-60-7
Oxolamine 959-14-8
Libexin 982-43-4
Levopropoxyphene hydrochloride 1596-70-9

Dextropropoxyphene hydrochloride

 1639-60-7

Tiopronin

 1953-02-2

Benproperine

 2156-27-6
Pipazethate 2167-85-3
Levopropoxyphene 2338-37-6
Carbocysteine 2387-59-9
Pheniramine aminosalicylate 2508-73-8

Drotebanol

 3176-03-2
Benproperine trihydrogen phosphate 3563-76-6
Bromhexine 3572-43-8
Promolate 3615-74-5
Nicocodine 3688-66-2
Cloperastine 3703-76-2
Norbutorphanol 3792-68-5
Acetyldihydrocodeine
 3861-72-1
Meprotixol 4295-63-0

Oxtriphylline

 4499-40-5
Mefenidramium metilsulfate 4858-60-0
Alloclamide hydrochloride 5107-01-7

Tipepidine

 5169-78-8
Alloclamide 5486-77-1
Ethyl dibunate 5560-69-0
Glaucine 5630-11-5
Levopropoxyphene napsylate anhydrous 5714-90-9
Noscapine DL-form 6035-40-1
Pipazethate hydrochloride 6056-11-7
Codeine 6059-47-8
beta-Methyl-alpha,alpha-diphenyl-1-piperidineethanol hydrochloride 6159-39-3
Dextromethorphan hydrobromide 6700-34-1
Codeine sulfate trihydrate 6854-40-6
Naphthonone 7114-11-6
Codoxime 7125-76-0
Diphenhydramine salicylate 7491-10-3
Opium 8008-60-4
Isoaminile cyclamate 10075-36-2
Eprazinone dihydrochloride 10402-53-6

Eprazinone

 10402-90-1

Benzylmorphine

 14297-87-1

Clobutinol

 14860-49-2
Cloperastine hydrochloride 14984-68-0
Sodium dibunate 14992-59-7
Bezitramide 15301-48-1
Amoxydramine camsilate 15350-99-9

Bibenzonium bromide

 15585-70-3

Droxypropine

 15599-26-5
Dropropizine 17692-31-8
Fominoben 18053-31-1
Peiminine 18059-10-4

Butamirate

 18109-80-3
Butamirate citrate 18109-81-4

Ambroxol

 18683-91-5
Hydroxygenkwanin 20243-59-8
Picoperine 21755-66-8

Nepinalone

 22443-11-4
Carbetapentane citrate 23142-01-0

Fedrilate

 23271-74-1
Verticine 23496-41-5
Ambroxol Hydrochloride 23828-92-4
Fominoben hydrochloride 24600-36-0
1-Phenethyl-4-hydroxysalicylamido-4-methylpiperidine hydrochloride 25552-58-3
2-Allyloxy-4-chloro-N-(2-piperidinoethyl)benzamide 25709-16-4
Piclobetol 25948-00-9
Ubisindine phosphate 26070-68-8
Ubisindine 26070-78-0
Niaprazine 27367-90-4
Isoaminile citrate 28416-66-2
Mofoxime 29936-79-6
Morclofone 31848-01-8
Probunafon 31852-19-4
N-Ethyl-4-methoxybicyclo(4.2.0)octa-1,3,5,7-tetraene-7-methylamine 32451-42-6
Pemerid nitrate 34114-01-7
Suxemerid sulfate 34144-82-6
Hydrocodone bitartrate 34195-34-1
Zipeprol 34758-83-3
3,17-Dimethylmorphinan 36304-82-2

Dimemorfan

 36309-01-0
Codeine phosphate 41444-62-6
Butorphanol 42408-82-2

Prenoxdiazine

 47543-65-7
Pemerid 50432-78-5
Anantine 50656-82-1
Isoanantine 50656-85-4
Rorifone 53078-90-3

Letosteine

 53943-88-7
Guacetisal 55482-89-8
Levopropoxyphene napsylate 55557-30-7
Moxazocine 58239-89-7
Butorphanol tartrate 58786-99-5
Domiodol 61869-07-6
N-(2'-Pyrrolidinoethyl)diphenylacetamide hydrochloride 63207-78-3
Broncho-binotal 63952-75-0
D-3-Methoxy-N-hydroxyethyl morphinan 65115-01-7
Proxorphan tartrate 69815-39-0
Doxofylline 69975-86-6
Vadocaine 72005-58-4

Stepronin

 72324-18-6
Heliosin 72746-38-4
3-Hydroxybutorphanol 75195-49-2
Contrapect 76095-55-1
Linctifed 77944-85-5
Sedocalaine 79084-79-0
Taziprinone 79253-92-2

Erdosteine

 84611-23-4
L-Tyrosyl-D-arginylglycyl-4-nitro-L-phenylalanyl-L-prolinamide diacetate 88331-14-0
Pholcolix 90326-84-4
Sinpeinine A 96997-98-7

Levodropropizine

 99291-25-5

Neltenexine

 99453-84-6
Hydroxybutorphanol tartrate 102043-41-4
Nestifylline 116763-36-1
Hexapneumine 118573-57-2
Moguisteine 119637-67-1
Asada-ame 124399-50-4
Codobromyl 126371-24-2
1-p-Chlorobenzyl-2-dimethylaminomethyl-1,2-cyclohexene 133763-16-3
Ebeiensine 139893-27-9
Hupehemonoside 143120-88-1
Hydroxybutorphanol 182296-54-4