AMOXICILLIN TRIHYDRATE

PRODUCT IDENTIFICATION

CAS NO. 26787-78-0 (Trihydrate)
34642-77-8 (Hydrochloride)
61336-70-7 (Anhydrous)

AMOXICILLIN

EINECS NO. 248-003-8
FORMULA

C16H19N3O5S-3H2O

MOL WT. 419.45

H.S. CODE

2941.10.5000

TOXICITY

 

SYNONYMS alpha-Amino-p-hydroxybenzylpenicillin; p-Hydroxyampicillin;
(-)-6-(2-Amino-2-(P-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0) heptane- 2-carboxylic acid; 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid; 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin; Sumox; Trimox; Trimox (Trihydrate); Utimox; Wymox; 6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid; D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid; AMPC; Anemolin; Aspenil; Augmentin; Betamox; Bristamox; Cabermox; Cemoxin; Cilamox; Clamoxyl; Clamoxyl (Trihydrate); Cuxacillin; D-(-)-alpha-amino-p-hydroxybenzyl penicillin trihydrate; Delacillin; Efpenix; Fisamox; Grinsil; Histocillin; Ibiamox; Imacillin; Larotid; Moxacin; Optium; Ospamox; Piramox; Polymox; Sawacillin; Sawacillin (Trihydrate); Simoxil; OTHER CAS RN: 33911-69-2; 71447-36-4; 81030-75-3

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions

APPLICATIONS

AMPICILLIN is a semisynthetic antibiotic, a member of the penicillin family of antibiotics. To extend the usefulness of the penicillins to the treatment of infections caused by gram-negative rods, the broad-spectrum penicillins (ampicillin, amoxicillin, carbenicillin, and ticarcillin) were developed.  It is created by attaching acid radicals to the central structure of 6-aminopenicillanic acid. Chemically, it is D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7 -oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid trihydrate.  Similar in action to penicillin G--the most widely used natural penicillin--ampicillin (or alpha-aminobenzylpenicillin) is more stable in stomach acids and therefore may be given orally; it is also more active against certain strains of bacteria. It is used regularly to treat common urinary-tract infections, some respiratory infections, and bacterial meningitis in children, although many strains of Hemophilus influenzae (the most common cause of bacterial meningitis) are now resistant to ampicillin, and it commonly is used along with other drugs. The potential side effects of ampicillin are similar to those of other penicillins--i.e., chiefly allergic reactions ranging from skin rashes and hives to life-threatening anaphylactic shock (very rare). People who are allergic to other drugs in this family are also likely to react to ampicillin. The incidence of skin rashes is higher with ampicillin than with other penicillins, a factor that suggests a possible toxic reaction, as well as a truly allergic response. AMOXICILLIN is a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Chemically it is (2S,5R,6R)-6-[(R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate. Amoxicillin is useful in treating urinary tract infections caused by gram-negative rods as well as in treating typhoid and enteric fevers.

Members of ampicillin derivatives

Product

CAS RN

Ampicillin sodium 69-52-3
Ampicillin 69-53-4
Penicillin G benzathine 1538-09-6
Metampicillin 6489-97-0
Ampicillin trihydrate 7177-48-2
Broadcillin 8067-85-4
Pivampicillin hydrochloride 26309-95-5
Epicillin 26774-90-3
Amoxicillin Trihydrate 26787-78-0
Ampicillin benzathine 33276-75-4
Pivampicillin 33817-20-8
Amoxicillin sodium 34642-77-8
Bacampicillin hydrochloride 37661-08-8
Pivampicillin pamoate 39030-72-3
Talampicillin hydrochloride 39878-70-1
Pivampicillin probenate 42190-91-0
Talampicillin 47747-56-8
Bacampicillin 50972-17-3
Combipenix 51004-51-4
Ampicillinoic acid 57457-66-6
Amoxicillin Anhydrous 61336-70-7
N-(N'-Methylasparaginyl)amoxicillin 63329-59-9
Aspoxicillin 63358-49-6
N-Propionylampicillin 74226-27-0
Amoxicillin-potassium clavulanate combination 74469-00-4
Amoxicillin-clavulanic acid mixture 79198-29-1
Lenampicillin hydrochloride 80734-02-7
Lenampicillin 86273-18-9
Sulacillin 94935-63-4
SALES SPECIFICATION

APPEARANCE

White or Almost White Powder

IDENTIFICATION

Comply Test

ASSAY

98.0 - 100.5 % (on Anhydrous basis)

CLARITY OF SOLUTION

Complies test

OPTICAL ROTATION

+290° - +315°

HEAVY METALS

20 ppm max

N,N-DIMETHYLANILINE

20 ppm max

SULFATED ASH

0.5% max

WATER

11.50% - 14.50%

PH

3.5 - 5.5 (0.25% W/V Solution)

BULK DENSITY

0.65 - 0.8 gr/ml (Compact Type)

TRANSPORTATION
PACKING  
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Respiratory sensitization. Skin sensitization. Hazard statements: May cause an allergic skin reaction. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.

GHS

 

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H317-H334

P STATEMENTS

P261-P280-P342 + P311

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

42/43

SAFETY PHRASES

22-36/37

PRICE INFORMATION