AMIKACIN SULFATE

PRODUCT IDENTIFICATION
CAS NO. 37517-28-5
39831-55-5 (sulfate)

AMIKACIN SULFATE

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EINECS NO. 254-648-6
FORMULA

C22H43N5O13-2H2SO4

MOL WT.

781.75

H.S. CODE

 2941.90.1010

TOXICITY

  
SYNONYMS Amikacin disulfate salt; Amikacin bis(sulphate);
Amiklin; Bb-k8; Biklin; Fabianol; Kaminax; Mikavir; Novamin; Pierami; O-3-Amino-3-deoxy- alpha-D -glucopyranosyl-(1-4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl- (1-6))-N( 3)-(4-amino-L-2- hydroxybutyryl) -2-deoxy-L-streptamine sulfate; Amikafur; Amitrex; Likacin; Lukadin;
SMILES

O([C@H]1[C@@H](C[C@@H]([C@H]([C@@H]1O) O[C@H]1O[C @@H]([C@ @ H] (O)[C@@H]([C@H]1O)O)CN)N)N C([C@H](CCN)O)= O)[C@H] 1O[C@@H]( [C@@H](O)[C@@H]([C@H]1O)N)CO. S(O)(O)(=O) =O.S(O)(O)(=O)=O

CLASSIFICATION

Antibacterial, Antibiotic

EXTRA NOTES

 A broad-spectrum antibiotic derived from kanamycin. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Other RN: 37357-52-1

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Amikacin

Google Scholar Search - Amikacin sulfate

Drug Information Portal (U.S. National Library of Medicine) - Amikacin sulfate

PubChem Compound Summary - Amikacin sulfate

Drug Bank -  Amikacin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Amikacin sulfate

http://www.ebi.ac.uk/ - Amikacin

http://www.ncbi.nlm.nih.gov/ - Amikacin sulfate

Local:
Amikacin sulfate [ chemically : D-Streptamine, O-3-amino-3-deoxy-alpha-D- glucopyranosyl- (1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))- N1-(4-amino-2-hydroxy-1- oxobutyl)- 2-deoxy-, (S)-sulfate (1:2) (salt)] is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. Its spectrum is somewhat broader than that of other aminoglycosides, including Serratia and Acinetobacter species, as well as certain staphylococci and streptococci. It is the most effective agent against gram-negative bacilli that have some aminoglycoside resistance. It is used for the treatment of serious infections resistant to gentamicin and tobramycin (bone infections, respiratory tract infections, endocarditis, and septicemia).

Aminoglycoside is any of a group of antibiotics derived from various species of Streptomyces or Micromonosporaceae, while some of which are produced synthetically. Aminoglycosides inhibit bacterial protein synthesis by binding with the 30S ribosomal subunit and in some cases the 50S subunit, causing miscoding and thus ihibiting initiation and elongation during protein synthesis. They include;

  • Amikacin
  • Gentamicin
  • Kanamycin
  • Neomycin
  • Netilmicin
  • Paromomycin
  • Streptomycin
  • Tobramycin
SALES SPECIFICATION

APPEARANCE

 white to off-white powder
POTENCY

674 - 790 ¥ìm/mg (Anhydrous basis)

IDENTIFICATION

pass (A,B,C,D,E)

SULFATE

 18.0 - 21.5%
STREPTOMYCIN B

3.0% max

pH

 2.0 - 4.0

CLARITY OF SOLUTION

pass

LOSS ON DRYING

13.0% max

OPTICAL ROTATION

+76.0 ~ +84.0°

CLARITY OF SOLUTION

90.0% min

RESIDUE ON IGNITION

1.0% max

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards:Target Organ Effect, Teratogen. Target Organs:ears, Kidney. May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be harmful if swallowed.

GHS

 

SIGNAL WORD

Warning

PICTOGRAMS

 

HAZARD STATEMENTS

H303

P STATEMENTS