PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

C1(NC(=O)NC1=O)NC(=O)N

CLASSIFICATION

Dermatologic agent, Vulnerary, Cosmetics chemical, Urea, Excipient, Hydantoin

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

0.5% at 25 C (freely disolve in alkalis)

REFRACTIVE INDEX

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

USA.gov - Allantoin

Wikipedia Linking - Allantoin

Google Scholar Search - Allantoin

Drug Information Portal (U.S. National Library of Medicine) - Allantoin

PubChem Compound Summary - Allantoin

Drug Bank -  Allantoin

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Allantoin

http://www.ebi.ac.uk/chebi/ -  Allantoin

http://www.ncbi.nlm.nih.gov/ -  Allantoin

Material Safety Data Sheet - Allantoin

Hazardous Substances Data Bank - Allantoin

EPA - Substance Registry Services - Allantoin

Local:
Allantoin, the diureide of glyoxylic acid, is a crystallizable oxidation product of uric acid found in allantoic and amniotic fluids, in fetal urine and in many plants. (Ureide is a compound derived from urea and contains acid radicles. Those from one molecule of urea, as alloxan, are monoureides; those derived from two, as uric acid, are diureides). Allantoin is an urinary excretion product of purine metabolism in most mammals but not in higher apes including humans. It is produced synthetically by the oxidation of uric acid. Allantoin is active in skin-softening (keratolytic effect) and rapid cell regeneration by precipitating proteins on skin. It is used as an abrasive and astringent agent in the end products include cosmetic lotions, creams, suntan products, scalp preparations, shampoos , lipsticks and and various aerosol preparations. It is used in topical pharmaceutical preparations. Allantoin has been used in various oral hygeine preparations such as toothpaste and mouthwash as well as in  eye drops to treat watering eyes and in ear drops to clean the ear canal. Alloxan is an oxidized product of uric acid by nitric acid. When administered to experimental animals, it produces selective destruction of the beta cells of the pancreas, causing hyperglycemia and ketoacidosis. Alloxan, a strong oxidizing agent, and its reduced product dialuric acid  form alloxantin (a hemiacetal) which is used as a raw material to produce ammonium purpurate dye, murexide (C₈H₅N₅O₆·NH₃) with heating at 100 C in ammonia gas. Murexide is used as a complexometric titration indicator and as a colorimetric reagent for measurement of calcium and rare earth metals.

APPEARANCE

ASSAY

MELTING POINT

255 C min

IRON

10ppm max

ARSENIC

3ppm max

UREA

0.5% max

GLYOXYLIC ACID

0.5% max

SULFATED ASH

0.1% max