ALBENDAZOLE

PRODUCT IDENTIFICATION
CAS NO. 54965-21-8 (Base)
54029-12-8 (sulfoxide)

ALBENDAZOLE
EINECS NO. 259-414-7
FORMULA C12H15N3O2S
MOL WT. 265.33

H.S. CODE

  

CLASSIFICATION

 Anthelmintic / Benzimidazole

TOXICITY

 Oral rat LD50: 2400 mg/kg
SYNONYMS Proftril; AlbendazolumL Albenza; Bilutac;
Methyl 5-propylthio-2-benzimidazolecarbamate; ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle; (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester; 5-(Propylthio)-2-carbomethoxyaminobenzimidazole; Albendazol; O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate; Zental; Zentel;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT 208 - 210 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Albendazole is an orally administered broad-spectrum benzimidazole anthelmintic used against helminths and in the treatment of hydatid cyst disease and neurocysticercosis. It is used to treat ruminant infestations by either roundworms or flatworms. It is a white to off-white powder; insoluble in water; soluble in dimethylsulfoxide, strong acids and strong bases; slightly soluble in methanol, chloroform, ethyl acetate and acetonitrile. Chemical designation is Methyl 5-(propylthio)-2-benzimidazolecarbamate.

Pharmacological actions of Albendazole:

  • Anthelmintic
  • Anti-Infective
  • Anticestodal
  • Antimitotic
  • Antiparasitic
  • Antiplatyhelmintic
  • Antiprotozoal
  • Mitosis Modulator
  • Tubulin Modulator

Anthelmintic (also spelled  anthelminthic) is a chemical substance used to expel or destroy tapeworms in domestic animals. Some common anthelmintic active ingredients classified by chemical structure include;

  • Benzimidazoles
    • Albendazole (CAS #: 54965-21-8)
    • Fenbendazole (CAS #: 43210-67-9)
    • Mebendazole (CAS #: 31431-39-7)
    • Oxfendazole (CAS #: 53716-50-0)
    • Oxibendazole ((CAS #: 20559-55-1)
    • Triclabendazole (CAS #: 68786-66-3)
  • Diphenylsulfides
    • Bithionol (CAS #:97-18-7)
    • Febantel (CAS #: 58306-30-2)
  • Hexahydropyrazines
    • Diethylcarbamazine (CAS #: 90-89-1)
    • Piperazine (CAS #: 110-85-0)
    • Praziquantel (CAS #: 55268-74-1)
  • Imidazothiazoles
    • Levamisole (CAS #: 14769-73-4)
    • Tetramisol (CAS #: 5036-02-2)
  • Macrocylic Lactones
    • Abamectin (CAS #: 71751-41-2)
    • Doramectin (CAS #: 117704-25-3)
    • Eprinomectin (CAS #: 123997-26-2)
      • Eprinomectin B1a (CAS#: 133305-88-1)
      • Eprinomectin B1b (CAS #: 133305-89-2)
    • Ivermectin (CAS #: 70288-86-7)
      • Ivermectin B1a (CAS #: 70161-11-4)
      • Ivermectin B1b (CAS #: 70209-81-3)
    • Moxidectin (CAS #: 113507-06-5)
  • Salicylanilide
    • Closantel (CAS #: 57808-65-8)
    • Niclosamide Base (CAS #: 50-65-7)
      • Niclosamide Monohydrate (CAS #: 7336-56-2)
      • Niclosamide Ethanolamine salt (CAS #: 1420-04-8)
      • Niclosamide Piperazine salt (CAS #: 34892-17-6)
    • Oxyclozanide (CAS #: 2277-92-1)
    • Rafoxanide  (CAS #: 22662-39-1)
  • Tetrahydropyrimidines
    • Morantel (CAS #: 20574-50-9)
    • Pytrantel Pamoate (CAS #: 22204-24-6)
  • Others
    • Clorsulon (CAS #: 60200-06-8)
    • Nitroxinil (CAS #: 1689-89-0)
SALES SPECIFICATION (USP)
Albendazole S-Oxide

APPEARANCE

 white to off-white powder

IDENTIFICATION

Complies Test A, B

ASSAY

99.0% min

SOLUBILITY

Complies

MELTING POINT

211 C

ASH

0.2% max

LOSS ON DRYING

1.0% max
Albendazole Base

APPEARANCE

 white to off-white powder

IDENTIFICATION

Complies Test A, B

ASSAY

98.0 - 101.0%

MELTING POINT

208 - 210 C

RESIDUE ON IGNITION

0.2% max

ASH

0.2% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO. FS0002
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 61-36/37/38, Safety Phrases: 53-26-37/39-45

PRICE INFORMATION