PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

SMILES

N12C(=C(CS[C@@]1([C@@H](C2=O)N)C)COC(=O)C)C(=O)O

CLASSIFICATION

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

3.0 ~ 5.0

REFRACTIVE INDEX

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - 7-Aminocephalosporanic acid

Wikipedia Linking - 7-ACA

Google Scholar Search - 7-Aminocephalosporanic acid

U.S. National Library of Medicine - 7-Aminocephalosporanic acid

PubChem Compound Summary - 7-Aminocephalosporanic acid

Drug Bank -  7-Aminocephalosporanic acid

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  7-Aminocephalosporanic acid

ChEBI (http://www.ebi.ac.uk/chebi/) -  7beta-Aminocephalosporanic acid

NCBI (http://www.ncbi.nlm.nih.gov/) -  7-Aminocephalosporanic acid

Hazardous Substances Data Bank - 7-Aminocephalosporanic acid

EPA - Substance Registry Services - 7-Aminocephalosporanic acid

Local:
APPLICATIONS: 7-Aminocephalosporanic Acid  [chemically, 3-(Acetyloxy-methyl)-7-amino- 8-oxo-5-thia-1- azabicyclo (4.2.0) oct-2-ene-2-carboxylic acid] is the active nucleus for the synthesis of cephalosporins and intermedaites; obtained by hydrolysis of cephalosporin C. Cephalosporin is a group of broad-spectrum beta-lactam antibiotics iclude cephradine, cephazolin, cephalexin, and cefadroxil (the first generation); cefuroxime, cephamandole, cefaclor, cefprozil, and cefoxitin (the second generation); cefotaxime, ceftazidime, cefodizime, ceftriaxone, cefixime, cefpodoxime, ceftibuten, and cefpirome (the third generation).

GENERAL DESCRIPTION OF CEPHALOSPORIN: Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium  and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids.

APPEARANCE

INDIVIDUAL IMPURITY

1.0% max (Desacetoxy-7-ACA, Desacetyl-7-ACA, Desacetyl-7-ACA-lactone: Cephalosporin C)

pH

3.0 ~ 5.0

+88° min

0.3% max

HEAVY METALS

50ppm max

MOISTURE

1.5% max

88.0% min (420 nm)

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Respiratory sensitization. Skin sensitization. Hazard statements: May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

GHS

Danger

PICTOGRAMS

HAZARD STATEMENTS

H317-H334

P STATEMENTS

P261-P280-P342 + P311

RISK PHRASES

42/43

SAFETY PHRASES

22-36/37