PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

4-Methoxyindole; 4-Methoxy-1H-indole;

CLASSIFICATION

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

66 - 69 C

REFRACTIVE INDEX

136 C

EXTERNAL LINKS & GENERAL DESCRIPTION

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Methoxyindole

PubChem Compound Summary - 4-Methoxyindole

Drug Bank - 4-Methoxyindole

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Methoxyindole

http://www.ebi.ac.uk/chebi/ -  4-Methoxyindole

http://www.ncbi.nlm.nih.gov/ -  4-Methoxyindole

Material Safety Data Sheet

http://www.sigmaaldrich.com/
Application: Reactant for preparation of ·GABA analogs, ·Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes ·Anticancer agents, ·Integrase strand-transfer inhibitors (INSTIs), ·Inhibitor of Proliferation of Colon Cancer Cells, ·Isomeridianin G as GSK-3ß inhibitors, ·HIV-1 integrase inhibitors, ·Inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

Local:
Indole, benzopyrrole, is a yellow crystalline powder with unpleasant aroma. It has the pyrrole ring (five-membered unsaturated ring structure composed of four carbon atoms and one nitrogen atom) which is fused to benzene ring. There are tautomerer called indolenine (unsubstituted 3H-indole) and structural isomer, isoindole. But they are unstable. Indole occurs in some plants or in coal tar, and is formed in the intestine during putrefaction and by certain cultures of bacteria. it is commercially synthesized from phenylhydrazine and pyruvic acid.  Indole structure is a motif in nature. Prominent examples include tryptophan (aromatic side chain amino acid), serotonin (neurotransmitter), auxin (plant growth hormone), and indigo (plant colorant). One more interesting point is all these compounds have functional branches at 3 position. Indole is used in perfumery and in preparing tryptophan, one of the 20 amino acids commonly found in animal proteins. It has important application in the industry of plant growth. It is used to prepare indoleacetic acid (auxin) and other plant growth substances which help the development of roots in plant. It is used to make selective herbicides. Indole and its derivatives are widely used in making perfumes, dyes, agrochemicals and medicines. 

APPEARANCE

98.0% min

66 - 70 C

HAZARD OVERVIEW

OSHA Hazards: Irritant

GHS

PICTOGRAMS

HAZARD STATEMENTS

H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338

RISK PHRASES

36/37/38

SAFETY PHRASES

26-36