4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE

PRODUCT IDENTIFICATION

CAS NO. 39512-49-7

4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE 

EINECS NO. 254-479-8
FORMULA C11H14ClNO
MOL WT. 211.69

H.S. CODE

 

TOXICITY

 

SYNONYMS 4-(4-chlorophenyl)-4-piperidinol; haloperidol metabolite I;
4-(4-Chlorophenyl)piperidin-4-ol;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to beige powder
MELTING POINT 138 - 141 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER 350mg/l at 20 C
pH  
VAPOR DENSITY

 

AUTOIGNITION

400 C

NFPA RATINGS

Health: 1; Flammability: ; Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions

APPLICATIONS

Piperidine, hexahydropyridine, is a family of heterocyclic organic compound derived from pyridine through hydrogenation. It has one nitrogen atom in the cycle. It is a clear liquid with pepper-like aroma. It boils at 106 C, soluble in water, alcohol, and ether. The major application of piperidine is for the production of Dipiperidinyl dithium tetrasulfide used as a rubber vulcanization accelerator. In pharmaceutical synthesis industry, it is used as a special solvent and a protecting group for peptide synthesis. Piperidine derivative compounds are used as intermediate to make crystal derivative of aromatic nitrogen compounds containing nuclear halogen atoms. Ring system compounds with nitrogen which have basic property play important roles as cyclic component in industrial field such as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts, antioxidants and as a catalyst for silicone esters. They are used in manufacturing pharmaceuticals.

4-(4-Chlorophenyl)-4-hydroxypiperidine is used as an intermediate for the synthesis of pharmaceuticals such as haloperidol (neuroleptic drug used to treat patients with psychotic illnesses, extreme agitation, or Tourette's syndrome) and loperamide (an opioid that slows down movements of the gut and is used to treat acute diarrhoea)

SALES SPECIFICATION

APPEARANCE

white to beige powder

ASSAY

99.0% min

MOISTURE

0.5% max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 28A/37/38/45