4-(2-AMINOETHYL)BENZENESULFONAMIDE

PRODUCT IDENTIFICATION

CAS NO. 35303-76-5

4-(2-AMINOETHYL)BENZENESULFONAMIDE

EINECS NO. 252-501-0
FORMULA C8H12N2O2S
MOL WT. 200.26

H.S. CODE

 
SMILES

 

TOXICITY

 
SYNONYMS 4-(2'-Aminoethyl)benzenesulfonamide
p-(2-Aminoethyl)benzenesulfonamide

CLASSIFICATION

BENZENESULFONAMIDE /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 142 - 149 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions

APPLICATIONS

4-(2-Aminoethyl)benzenesulfonamide is an intermediate  to prepare sulfonylurea drugs like Glipizide (an  antidiabetic agent, chemically 1-cyclohexyl-3-[[p-(2-(5-methyl pyrazine carboxamido) ethyl]phenyl] sulfonyl] urea). Sulfonylureas: a class of oral hypoglycaemic agents that exert hypoglycemic activity by stimulating the pancreas to secrete more insulin, active in type II diabetes only. Sulfonylureas have a phenyl ring nucleus with two branched chains in chemical structure. They can induce hypoglycemia which  is potential life threatening side effect in case of over-dose.

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder
PURITY

98.0% min

LOSS ON DRYING 0.5% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 24/25-28A-37-45
GENERAL DESCRIPTION OF AMIDE
Amide is a group of organic chemicals with the general formula RCO-NH2 such as acetamide, where 'R' groups range from hydrogen to various linear and ring structures or a compound with a metal replacing hydrogen in ammonia such as sodium amide, NaNH2. Amide is formed from of ammonia (NH3) and a carboxylic acid in which a carbon atom is double bonded to oxygen and also to an hydroxyl group or by reaction of an acid chloride, acid anhydride, or ester with an amine. An amide is hydrolyzed to yield an amine and a carboxylic acid. The reverse of this process results in the loss of water and is used in nature to link amino acids to form proteins, the secondary structure of which is due in part to the hydrogen bonding abilities of amides. Sulfonamides are analogs of amides in which the atom double bonded to oxygen is sulfur rather than carbon. Polyamide is a polymer containing repeated amide groups, as in various kinds of nylon and polyacrylamides.