4,4'-DIFLUOROBENZHYDRYLPIPERAZINE

PRODUCT IDENTIFICATION

CAS NO. 27469-60-9

4,4'-DIFLUOROBENZHYDRYLPIPERAZINE 

EINECS NO. 248-476-0
FORMULA C17H18F2N2
MOL WT. 288.34

H.S. CODE

 

TOXICITY

 

SMILES

 

SYNONYMS 1-Bis(4-fluorophenyl)methyl piperazine;
1-(4,4'-Difluorobenzhydryl)piperazine;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder
MELTING POINT 90 - 95 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER 345 mg/l
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and  poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane. Piperazine is a main moiety in psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes. Benzylpiperazine is bannaed in many countries. Benzylpiperazine  has been used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an important role in biological research and drug manufacturing industry including the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic, antiemetic and antimigraine agents. The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants.

Benzhydryl compounds contain two benzene rings which substitute hydrogen atoms in the methane molecule. This structure does not allow the fusion of benzene ring. This nomenclature system is particularly useful to describe the groups attached to the benzene rings and the additional substituents on the methane. The benzhydryl structure features as the motif for modified fibers, polymers and curing agents. The benzhydryl motif is a fundamental component also in drugs such antihistamines, antihypertensive agents and antiallergenic agents. 4,4'-Difluorobenzhydrylpiperazine is used as an intermediate for pharmaceutical preparations.

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

98.0% min

MELTING POINT 90 - 95 C
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS 6.1 (Packing Group: III)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 25, Safety Phrases: 28B/45