1,2-BENZISOTHIAZOLIN-3-ONE (BIT)

1,2-BENZISOTHIAZOLIN-3-ONE

PRODUCT IDENTIFICATION

CAS NO.

2634-33-5

1,2-BENZISOTHIAZOLIN-3-ONE

EINECS NO.

220-120-9

FORMULA

C₇H₅NOS

MOL WT.

151.18

H.S. CODE

2934.99.3900

TOXICITY

SYNONYMS

1,2-Benzisothiazol-3(2H)-one; BIT; Proxel;

,2-Benzisothiazolin-3-one; Benzisothiazol-3(2H)-one; Benzisothiazolin-3-one;

SMILES

c12c(cccc2)s[nH]c1=O

CLASSIFICATION

Preservative, Anti-Infective, Disinfectant, Hematologic agent, Platelet Aggregation Inhibitor. Isothiazolinone

EXTRA NOTES

Preservative in plastic emulsion which causes contact dermatitis.
EPA Pesticide Chemical Code 098901
Other RN: 40991-37-5, 54392-14-2, 75037-67-1, 101964-01-6, 1094749-54-8, 552320-00-0, 919284-21-2

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to pale yellow powder

MELTING POINT

154 ~ 158 C

BOILING POINT

204 ~ 205 C

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

REFRACTIVE INDEX

FLASH POINT

171 C

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & EXTERNAL LINKS

Isothiazolinones containing sulfur atom (S), nitrogen (N), oxygen (O) at 3 position and hydrogen (H) can find application for making broad-spectrum biocides and preservatives such as antiseptic agents, bactericides, slimicides, and fungicides. The biggest application is in paint industry especially marine antifouling agent. They are also used in adhesives, cutting oils, water systems, cosmetics, household goods and wound protectant for pruning cuts. They are also used as pulp and wood impregnating agents as well as in leather, fur and polymer process. It is known to cause allergy and chemical burn if high concentration is used in personal care products and cosmetics.

The list of isothiazolinones include;

Material	CAS #	EINECS #
(4-Chlorobenzyl)-3(2H)-isothiazolone	26530-09-6
1,2-Benzisothiazolin-3-one	2634-33-5	220-120-9
2-Butyl-1,2-benzisothiazolin-3-one	4299-07-4
2-Methyl-4,5-trimethylene-4-isothiazolin-3-one	82633-79-2
2-Methyl-4-isothiazolin-3-one	2682-20-4	220-239-6
2-Methyl-3-isothiazolone hydrochloride	26172-54-3	247-499-3
2-Octyl-3(2H)-isothiazolone	26530-20-1	247-761-7
4,5-Dichloro-2-cyclohexyl-4-isothiazolin-3-one	57063-29-3
4,5-Dichloro-2-octyl-3(2H)-isothiazolone	64359-81-5	264-843-8
4-Chloro-2-octyl-3(2H)-isothiazolone	64359-80-4	264-842-2
5-Chloro-2-(4-chlorophenylmethyl)-3(2H)-isothiazolone	66159-95-3
5-Chloro-2-methyl-4-isothiazolin-3-one	26172-55-4	247-500-7
5-Chloro-2-methyl-3(2H)-isothiazolone, calcium chloride complex	57373-19-0
5-Chloro-2-methyl-2H-isothiazol-3-one hydrochloride	26530-03-0	247-760-1
2-Methyl-4-isothiazolin-3-one calcium chloride	57373-20-3
Mixtures of these materials

Common biocides ( antiseptic agents, preservatives, bactericides, slimicides, fungicides) in cosmetics are parabens, isothiazolones, formaldehyde and formaldehyde releasing substances such as quaternium 15, diazolidinyl urea.

Wikipedia Linking: http://en.wikipedia.org/wiki/Benzisothiazolinone

Isothiazolinones are used in cosmetics and shampoos as a biocide to kill fungus and bacteria. Unlike the preservatives DMDM hydantoin and imidazolidinyl urea also commonly used in these products, isothiazolinones do not release formaldehyde, to which some people are sensitive. Some people are sensitive to isothiazolinones. (http://sci-toys.com/)

Some researchers noted that fungus growth is inhibited when highly acidic pickle baths are used, and therefore the application of fungicides is not necessary.7 However, in spite of this inhibition, acid hydrolyze occurs in leather under these conditions, and low acid use in pickled pelts is not recommended. pH level measuring between 1.4 and 1.6 in leathers inhibits fungus growth, yet hydrolyzes in leather proteins may cause pH increase, which provides a more ideal environment for the fungi.3 According to the general opinion, fungicide use is necessary in pickled and wet blue leathers that require long storage periods. Currently, products that contain active materials of 2-Thiocyanomethylthiobenzotiazole (TCMTB) and N-octyl-isothiazolinone (N-OITZ) are widely used in the protection of leather against fungi. On the other hand, fungi problem is still observed in some tanneries despite fungicide use. Thus, these two products that contain active materials were treated with pickled and chrome-tanned leathers in active doses recommended by the manufacturer, and the growth of different fungi in leather was examined in accordance with the standards. (http://www.cueronet.com/)

SALES SPECIFICATION

APPEARANCE

white to pale yellow powder

ASSAY

98.0% min

MELTING POINT

154 - 158 C

TRANSPORTATION

PACKING

HAZARD CLASS

9. Packing group: III

UN NO.

3077

SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards:Harmful by ingestion., Skin sensitiser, Irritant. Eyes: Causes eye irritation. Skin: Harmful if absorbed through skin. Causes skin irritation. Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Ingestion: Harmful if swallowed.

GHS

SIGNAL WORD

Danger

PICTOGRAMS