beta-CYCLODEXTRIN HYDRATE

PRODUCT IDENTIFICATION

CAS NO. 7585-39-9 (Base) 68168-23-0 (Hydrate) 85490-99-9 (Undecahydrate)

beta-CYCLODEXTRIN

EINECS NO. 231-493-2
FORMULA

C42H70O35·H2O

MOL WT. 1134.99

H.S. CODE

2940.00.6000

TOXICITY

Oral Rat LD50: 18800mg/kg
SYNONYMS beta-Cycloamylose; beta-Cycloheptaamylose; Betadex;
beta-Dextrin; Cycloheptaamylose; Cycloheptaglucan; Cycloheptaglucosan; Schardinger beta-dextrin; Cyclomaltoheptaose; Kleptose; beta-Cycloamylose; Other RN: 37331-89-8, 47918-72-9, 449728-55-6
SMILES O1[C@H]2[C@@H]([C@H]([C@@H]([C@H]1CO)O[C@@H]1[C@H](O )[C@@H](O)[C@@H]([C@H](O1)CO)O[C@H]1O[C@@H]([C@H]([C@ @H]([C@H]1O)O)O[C@@H]1[C@@H]([C@@H]([C@@H]([C@H](CO) O1)O[C@H]1O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@ @H]([C@H]3O)O)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO) O2)O)O)[C@@H]([C@H]1O)O)CO)O)O)CO)O)O

CLASSIFICATION

Carcinogens, sequestering agent

EXTRA NOTES

Forms clathrates. Produces a water-soluble complex with dansyl chloride for the fluorescent labeling of proteins

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT

298 C

BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 18.5 g/l at 25 C
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health: 1 Flammability: 1 Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under normal conditions. 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

http://www.eurocdsoc.com/
The natural α-, β- and γ-cyclodextrin (αCD, βCD and γCD) consist of six, seven, and eight glucopyranose units, respectively. The natural cyclodextrins, in particular βCD, are of limited aqueous solubility meaning that complexes resulting from interaction of lipophiles with these cyclodextrin can be of limited solubility resulting in precipitation of solid cyclodextrin complexes from water and other aqueous systems. In fact, the aqueous solubility of the natural cyclodextrins is much lower than that of comparable acyclic saccharides. This is thought to be due to relatively strong intermolecular hydrogen bonding in the crystal state. Substitution of any of the hydrogen bond forming hydroxyl groups, even by lipophilic methoxy functions, results in dramatic improvement in their aqueous solubility. Water-soluble cyclodextrin derivatives of commercial interest include the hydroxypropyl derivatives of βCD and γCD, the randomly methylated β-cyclodextrin (RMβCD), and sulfobutylether β-cyclodextrin sodium salt (SBEβCD).....

Local: Cyclic structure oligomers of glucose ( called cyclodextrins) are obtained from the starch digests of the bacteria Bacillus macerans. The individual glucose units are connected by 1,4 bonds. The most abundant cyclodextrins are alpha, beta and gamma cyclodextrin which have 6,7 and 8 glucose units respectively. The interior cavity is hydrophobic and the outside of the molecule is hydrophilic. The enhanced of characteristics such as stability, aqueous solubility, and reduced volatility, can be modified through mainly propoxylation reactions of them. Potential applications of cyclodextrins include water-soluble pharmaceuticals, prolonged drug release, tabletting and herbicides and pesticides.

GENERAL DESCRIPTION OF DEXTRIN: Dextrin is a polymeric carbohydrate which are formed during the hydrolysis of starch to sugars by heat, by acids, and by enzymes. (Maltose, sucrose and lactose are disaccharides of same empirical formula (C12H22O11) but are isomers differs from in structure). Dextrin and starch have the general formula, -[Cx(H2O)y)]n- (y = x - 1), in which glucose units are joined to one another usually head-to-tail, but dextrin has a smaller and less complex molecule than starch. Dextrin is soluble in water but is precipitated by alcohol. It's chemical properties rely on the extent of the starch from which they are derived. Some dextrin react with iodine to give a blue color and is soluble in 25% alcohol (called amylodextrin); others a reddish-brown color and soluble in 55% alcohol (called erythrodextrin); and still others yield no color at all with iodine and soluble in 70% alcohol (called achrodextrin). It is also identified by dextrose equivalence (DE) which is a measure of reducing power compared to the standard of 100 (dextrose). The higher DE is the more extent of starch depolymerization. Maltodextrin is the product of low DE. Dextrin forms a strongly adherent paste when mixed with water and it is used as adhesive in the manufacture of gummed tapes, textiles and paper. It is used in producing nutritional products.

Some examples of commercially available cyclodextrin, or derivatives thereof, are as follows:

  • alpha-Cyclodextrin (CAS #: 10016-20-3)
  • alpha-Cyclodextrin phosphate Sodium salt (CAS #: 199684-60-1)
  • alpha-Cyclodextrin, sulfated Sodium salt Hydrate (CAS #: 699020-02-5)
  • Hexakis (2,3,6-tri-O-acetyl)-alpha-cyclodextrin
  • Hexakis (2,3,6-tri-O-methyl)-alpha-cyclodextrin
  • Hexakis(2,3,6-tri-O-octyl)-alpha-cyclodextrin (CAS #: 140395-31-9)
  • Hexakis-6-bromo-6-deoxy-alpha-cyclodextrin (CAS #: 53784-82-0)
  • Hexakis-6-iodo-6-deoxy-alpha-cyclodextrin (CAS #: 131105-41-4)
  • Hexakis (6-O-tertbutyl-dimethylsilyl)-alpha-cyclodextrin
  • Butyl-alpha-cyclodextrin
  • Succinyl-alpha-cyclodextrin
  • (2-Hydroxypropyl)-alpha-cyclodextrin (CAS #: 128446-33-3)
  • beta-Cyclodextrin (CAS #: 7585-39-9)
  • beta-Cyclodextrin Hydrate (CAS #: 68168-23-0)
  • beta-Cyclodextrin phosphate Sodium salt (CAS #: 199684-61-2)
  • beta-Cyclodextrin sulfate
  • beta-Cyclodextrin, sulfated Sodium salt (CAS #: 37191-69-8)
  • Hydroxypropyl-beta-cyclodextrin (CAS #: 94035-02-6)
  • 6-Monodeoxy-6-monoamino-beta-cyclodextrin
  • 6-O-alpha-D-Glucosyl-beta-cyclodextrin (CAS #: 92517-02-7)
  • 6-O-alpha-Maltosyl-beta-cyclodextrin Hydrate (CAS #: 104723-60-6)
  • Heptakis-6-azido-6-deoxy-beta-cyclodextrin
  • Heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 196398-66-0)
  • Heptakis-(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 201346-23-8)
  • Heptakis(2,6-di-O-methyl)-beta-cyclodextrin (CAS #: 51166-71-3)
  • Heptakis-(2,6-di-O-ethyl)-beta-cyclodextrin (CAS #: 111689-03-3)
  • Heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (CAS #: 55216-11-0)
  • Heptakis(2,3,6-tri-O-acetyl)-beta-cyclodextrin
  • Heptakis-(2,3,6-tri-O-benzoyl)-beta-cyclodextrin (CAS #: 23666-43-5)
  • Heptakis-(2,3,6-tri-O-ethyl)-beta-cyclodextrin (CAS #: 111689-01-1)
  • Heptakis-6-iodo-6-deoxy-beta-cyclodextrin (CAS #: 30754-23-5)
  • Heptakis-6-(dimethyl-tert-butylsilyl)-6-deoxy-beta-cyclodextrin
  • Heptakis-6-bromo-6-deoxy-beta-cyclodextrin
  • Monoacetyl-beta-cyclodextrin
  • Diacetyl-beta-cyclodextrin
  • Triacetyl-beta-cyclodextrin (CAS #: 23739-88-0)
  • Heptakis(3-O-acetyl-2,6-di-O-methyl)-beta-cyclodextrin (CAS #: 131889-29-7)
  • Heptakis-(6-O-maltosyl)-beta-cyclodextrin
  • Heptakis(6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 197587-31-8)
  • Heptakis(6-O-t-butyldimethylsilyl-2,3-di-O-acetyl)-beta-cyclodextrin
  • Succinyl-(2-hydroxypropyl)-beta-cyclodextrin
  • (2,6-Di-O-)ethyl-beta-cyclodextrin
  • (2-Carboxyethyl)-beta-cyclodextrin
  • (2-Hydroxyethyl)-beta-cyclodextrin (CAS #: 128446-32-2)
  • (2-Hydroxypropyl)-beta-cyclodextrin (CAS #: 128446-35-5)
  • Butyl-beta-cyclodextrin
  • Methyl-beta-cyclodextrin (CAS #: 128446-36-6)
  • Silyl((6-O-tert-butyldimethyl)-2,3,-di-O-acetyl)-beta-cyclodextrin
  • Succinyl-beta-cyclodextrin
  • gamma-Cyclodextrin (CAS #: 17465-86-0)
  • gamma-Cyclodextrin Hydrate (CAS #: 91464-90-3)
  • gamma-Cyclodextrin phosphate Sodium salt (CAS #: 199684-62-3)
  • Sulfopropyl-beta-cyclodextrin
  • Carboxymethyl-gamma-cyclodextrin
  • Octakis (2,3,6-tri-O-acetyl)-gamma-cyclodextrin
  • Octakis (2,3,6-tri-O-methyl)-gamma-cyclodextrin
  • Octakis (2,6-di-O-pentyl)-gamma-cyclodextrin
  • Octakis-6-(dimethyl-tert-butylsilyl)-6-deoxy-gamma-cyclodextrin
  • Octakis-6-bromo-6-deoxy-gamma-cyclodextrin (CAS #: 53784-84-2)
  • Octakis-6-iodo-6-deoxy-gamma-cyclodextrin (CAS #: 168296-33-1)
  • Octakis (6-O-t-butyldimethylsilyl)-gamma-cyclodextrin
  • Succinyl-gamma-cyclodextrin
  • (2-Hydroxypropyl)-gamma-cyclodextrin (CAS #: 128446-34-4)
  • Acetyl-gamma-cyclodextrin
  • Butyl-gamma-cyclodextrin
SALES SPECIFICATION
APPEARANCE white powder

PURITY

98.0% min

SPECIFIC ROTATION

+160° ~ +165° (c=1 in H2O on dry basis)

MOISTURE

5.0% max
TRANSPORTATION
PACKING
25kgs in drum
HAZARD CLASS Not regulated
UN NO.  
SAFETY INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 24/25-28A-37-45

PRICE INFORMATION