alpha-ZERANOL

PRODUCT IDENTIFICATION
CAS NO. 26538-44-3

alpha-ZERANOL

EINECS NO. 247-769-0
FORMULA C18H26O5
MOL WT. 322.40

H.S.CODE

 2932.20.2000

TOXICITY

  
SYNONYMS alpha-Zearalanol; Zearalanol; THFES (HM); Zearalanol;
3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2- benzoxacyclo tetradecin-1- one; 2,4-Dihydroxy-6-(6a,10-dihydroxyundecyl) benzoic acid mu-lactone; (3S,7R)-(+)-3,4,5,6,7,8,9, 10,11,12 -Decahydro-7,14,16-trihydroxy- 3-methyl-1H-2- benzoxacyclotetradecin-1-one; (3S,7X)-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2- benzoxacyclotetradecin-1-one; (6X,10S)-6-(6,10-Dihydroxyundecyl)-beta-resorcylic acid mu-lactone; Zearanol; Zeranol; Zeranolum; (3S,11E)-14,16-Dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)- dione; Other RN: 5975-81-5, 21307-30-2, 24507-00-4, 39487-91-7, 40036-43-9
SMILES

c12c(c(cc(c1)O)O)C(O[C@H](CCC[C@@H](CCCCC2)O)C)=O

CLASSIFICATION

Anabolic, Non-steroidal estrogen

EXTRA NOTES

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 178 - 185 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 0.002g/100ml

 

 

pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 

FLASH POINT  
STABILITY Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Zeranol

PubChem Compound Summary - Zeranol

IPCS INCHEM -  Zeranol

Drug Bank -  Zeranol

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Zeranol

http://www.ebi.ac.uk/ -  Zeranol

http://www.ncbi.nlm.nih.gov/ -  Zeranol

http://www.breastcancerfund.org/
Zearalenone and its synthetic derivative zeranol (Ralgro) are estrogenic compounds to which cattle and swine in the U.S. meat industry are extensively exposed. Natural sources of zearalenone come from contamination of feed sources, including corn silage and hay, by the fungus Fusarium, which is an active producer of the chemical (Benzoni, 2008; Mirocha, 1979). Contamination of food by zearalenone and its natural metabolites (breakdown products) has been associated with the development of precocious puberty-a known risk factor for breast cancer-in young girls (Massart, 2008). These compounds have also been shown to enhance proliferation of ER+ human breast tumor cells in vitro through estrogen-mediated pathways and activation of gene profiles similar to those activated by the natural hormone estradiol (Khosrokhavar, 2009; Parveen, 2009).

Local:
Zeranol is a non-steroidal estrogenic growth stimulant that is used in veterinary medicine and has been used for human. The use for growth promotion in food animals was banned in the EU. An anabolic-estrogenic agent promote cell growth and division, resulting in growth of muscle tissue and sometimes bone size and strength. Testosterone and androgen are examples. Zeranol is also called zearalenol as it is a reduction product of zearalenone, an estrogenic mycotoxin product. Oestradiol-17beta, testosterone, progesterone, and trebolne are also used as growth stimulants for food animals.

Non-steroidal estrogen analog

CAS RN
Equol 531-95-3
2-sec-Butylphenol 89-72-5
Diethylstilbestrol 56-53-1
Bisphenol A 80-05-7
Dienestrol 84-17-3
Coumestrol 479-13-0
Allenolic acid 553-39-9
Chlorotrianisene 569-57-3
4-Octylphenol 1806-26-4
Hexestrol 5635-50-7
Zearalenone 17924-92-4
Zeranol 26538-44-3
SALES SPECIFICATION

APPEARANCE

 white crystalline powder
ASSAY

97.0% min

MELTING POINT

178 - 185 C

OPTICAL ROTATION

+44.5° ~ +47.5°

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.1% max

beta-ZERABOL

1.5% max
HEAVY METALS 20ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards:Target Organ Effect, Irritant, Teratogen, Reproductive hazard. Target Organs: Reproductive system.

GHS

 
SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H315-H319-H335-H360

P STATEMENTS

P201-P261-P305 + P351 + P338-P308 + P313
EC DIRECTIVES

 
HAZARD CODES

RISK PHRASES

60-36/37/38

SAFETY PHRASES

53-36/37/39-45
PRICE INFORMATION