ZEARALENONE

PRODUCT IDENTIFICATION

17924-92-4

241-864-0

H.S. CODE

TOXICITY

Zearalenone; Zenone; trans-Zearalenone;

(-)-Zearalenone; (10S)-Zearalenone; (S)-(-)-Zearalenone; (S)-Zearalenone; 6-(10-Hydroxy-6-oxo-trans-1-undecenyl)-beta-resorcylic acid lactone; trans-14,16-Dihydroxy-3-methyl-7-oxobenzoxacyclotetradec-11-en-1-one; trans-6-(10-Hydroxy-6-oxo-1-undecenyl)resorcylic acid mu-lactone; Other RN: 18695-28-8

c12c(cc(cc2O)O)C=CCCCC(=O)CCC[C@@H](OC1=O)C 

CLASSIFICATION

Non-steroidal estrogen

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

Slightly soluble in hexane. Soluble in benzene, acetonitrile, dichloromethane, methanol, acetone.

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Zearalenone

PubChem Compound Summary - Zearalenone

IPCS INCHEM -  Zearalenone

Drug Bank -  Zearalenone

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Zearalenone

http://www.ebi.ac.uk/ -  Zearalenone

http://www.ncbi.nlm.nih.gov/ -  Zearalenone

http://www.ansci.cornell.edu/
Mycotoxins produced by Fusarium spp. are of two general types: 1) the nonestrogenic trichothecenes, including DON, nivalenol, T-2 toxin, and diacetoxyscripenol, and 2) the mycoestrogens, including Zearalenone (ZEN) and zearalenol . Zearalenone and zearalenol are both estrogenic resorcylic acid lactone compounds produced by the fungi Fusarium spp. (Diekman and Green, 1992) Despite their structural dissimilarity to the steriodal estrogens, ZEN and several of its derivatives possess estrogenic activity. ZEN undergoes a folding such that hydroxyl or potential hydroxyl groups become appropriately orientated to facilitate binding to tissue receptors that normally bind estrogens. Similar binding affinities for ZEN have been determined for the estrogen receptor in sheep and calf uterus.(Diekman and Green, 1992)

Local:
Zeranol is a non-steroidal estrogenic growth stimulant that is used in veterinary medicine and has been used for human. The use for growth promotion in food animals was banned in the EU. An anabolic-estrogenic agent promote cell growth and division, resulting in growth of muscle tissue and sometimes bone size and strength. Testosterone and androgen are examples. Zeranol is also called zearalenol as it is a reduction product of zearalenone, an estrogenic mycotoxin product. Oestradiol-17beta, testosterone, progesterone, and trebolne are also used as growth stimulants for food animals.

APPEARANCE

98.0% min

MELTING POINT

159 ~ 162 C

HAZARD OVERVIEW

OSHA Hazards:Target Organ Effect, Irritant, Teratogen, Reproductive hazard. Target Organs: Reproductive system.

GHS

PICTOGRAMS

HAZARD STATEMENTS

H314-H361

P STATEMENTS

P280-P305 + P351 + P338-P310

RISK PHRASES

34

SAFETY PHRASES

26-36/37/39-45