RIBOFLAVIN

PRODUCT IDENTIFICATION

CAS NO.

83-88-5

RIBOFLAVIN

EINECS NO. 201-507-1
FORMULA C17H20N4O6
MOL WT. 376.37

H.S. CODE

2936.23.0000

TOXICITY

Oral Rat LD50: > 10gm/kg
SYNONYMS 7,8-Dimethyl-10-ribitylisoalloxazine;
3,10-Dihydro-7,8-dimetyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl] benzo[g]pteridine-2,4-dione; Ovoflavin; Zinvit-G; Riboflavin; Lactoflavin; Vitamin B2; 6,7-Dimethyl-9-D-ribitylisoalloxazine, 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine; 7,8-Dimethyl-10-ribitylisoalloxazine; Aqua-Flave; Beflavin; Beflavine; 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)- benzo(g) pteridine-2,4(3H,10H)-dione; 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo(g)pteridin- 10(2H)-yl)-D-ribitol; Dermadram; Fiboflavin; Flavaxin; Flavin BB; Flaxain; Hyflavin; 7,8-Dimethyl-10- (D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine; 7,8-Dimethyl-10-D-ribitylisoalloxazine; Lactobene; Lactoflavin; Lactoflavine; Ribipca; Ribocrisina; Riboderm; Riboflavin; Riboflavina; Riboflavine; Riboflavinequinone; Riboflavinum; Ribosyn; Ribotone; Ribovel; Russupteridine Yellow III; Vitaflavine; Vitamin B2 ; Vitamin Bi; Vitamin G; Vitasan B2; Other RN: 130609-39-1, 535950-32-4. 890044-91-4
SMILES n1(c2c(nc3c1nc(=O)[nH]c3=O)cc(C)c(c2)C)C[C@H]([C@H] ([C@H](CO)O)O)O

CLASSIFICATION

Natural Colorant, Vitamins, Dermatologic agent, Photosensitizing agent, Radiation-Sensitizing agent, Enzyme co-factor

CLASSIFICATION

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as Flavin mononucleotide and Flavin-adenine dinucleotide.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow to orange crystalline powder
MELTING POINT 280 - 290 C (Decomposes)
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER

Slightly soluble

SOLVENT SOLUBILITY

Soluble in dilute alkaline solutions, insoluble in alcohol

VAPOR DENSITY

 

pKa 10.2 (Dissociation Constant at 25 C)
log P -1.46E+00 (Octanol-water)
VAPOR PRESSURE 8.92E-22 (mmHg at 25 C)
HENRY LAW CONSTANT 3.59E-19 (atm-m3/mole at 25 C)
OH RATE CONSTANT 2.47E-10 (cm3/molecule-sec at 25 C Atmospheric)

AUTOIGNITION

 

NFPA RATINGS

Health hazard: 0, Fire: 0, Reactivity Hazard: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions. Light sensitive.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Riboflavin

http://www.idpas.org/
Riboflavin deficiency should be considered a possible risk factor for preeclampsia. Insufficient concentrations of the riboflavin-derived cofactors flavin adenine dinucleotide and flavin adenine mononucleotide could contribute to the established pathophysiologic changes including mitochondrial dysfunction, enhanced oxidative stress, and disturbances in nitric oxide release.

http://www.eatright.org/
You have heard of the many vitamins and minerals our body needs to stay healthy, but you may not know specifically what they do for you. For example, you may know you need thiamin, riboflavin and niacin, but do you know
why you need each of them?

  • Thiamin helps produce energy from carbohydrates in all cells of your body. Thiamin can be found in whole-grain and enriched grain products such as bread, rice, pasta and tortillas.
  • Riboflavin helps produce energy in all cells of your body and change an amino acid called tryptophan in your food into niacin. Riboflavin is found in milk and other dairy foods, enriched breads. Eggs, green, leafy vegetables and nuts provide smaller amounts.
  • Niacin helps your body use sugars and fatty acids, helps enzymes function normally in your body and helps produce energy. Foods high in protein are usually good sources of niacin such as poultry, fish, beef, peanut butter and legumes.

Consult a registered dietitian to find out how much of each vitamin is right for you. Remember, a variety of foods with plenty of vitamins and minerals is part of your ticket to good health.

Local:
Riboflavin: A member of the vitamin B complex (water-soluble) including thiamine (vitamin B1), riboflavin (vitamin B2), riboflavin 5'- phosphate, nicotinic acid, Vitamin B6 Group (Pyridoxine, pyridoxal, pyridoxamine), panthothenic acid (vitamin B3 or vitamin B5), inositol, p-aminobenzoic acid, biotin (vitamin B7), folic acid (vitamin B9), and vitamin B12 (cobalamins). Riboflavin is a water-soluble yellow to orange fluorescent pigment with the chemical structure of substituted isoalloxazine ring system linked to ribitol. (Flavin is a water-soluble compound containing the isoalloxazine nucleus which is characterized by a yellow color and intense green fluorescence when oxidized. Ribitol is a sugar alcohol formed by reduction of the carbonyl group of ribose). Riboflavin is essential to human nutrition as a component of two coenzymes;  flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) of flavoproteins, that are associated with several respiratory enzymes in plants and animals as electron carriers, important in biochemical oxidations and reductions. The deficiency of riboflavin results in the disease beriberi. The phosphoric acid esters of riboflavin are administered orally or parenterally in the treatment of dietary riboflavin deficiency.

  • Riboflavin 5'-Phosphate (Flavin Mononucleotide, FMN): serving as an electron carrier in biochemical oxidations and reductions; acting as a coenzyme for a number of oxidative enzymes, including NADH dehydrogenase.
  • Riboflavin 5'-Phosphate sodium: the sodium salt of riboflavin 5'-phosphate; administered orally or parenterally in the treatment of dietary riboflavin deficiency.
  • Riboflavine 5'-Adenosine Diphosphate (Flavin Adenine Dinucleotide. FAD): serving as an electron carrier in biochemical oxidations and reductions; forming prosthetic group of many flavoprotein enzymes, including D-amino acid oxidase and xanthine oxidase; a coenzyme composed of riboflavin 5'-phosphate (FMN) and adenosine 5'-phosphate linked by a pyrophosphate bond.
  • Flavin Adenine Dinucleotide Sodium: the sodium salt of Riboflavine 5'-Adenosine Diphosphate ; administered orally or parenterally in the treatment of dietary riboflavin deficiency.

SALES SPECIFICATION

BIBLIOGRAPHY

USP23 / BP93

APPEARANCE

yellow to orange crystalline powder

IDENTIFICATION

Complies (Test A, B)

ASSAY

98.0 ~102.0%

OPTICAL ROTATION

+56.5° ~ +59.5°

LOSS ON DRYING

1.5% max

RESIDUE ON IGNITION

0.2% max

IMPURITY

Complies

TRANSPORTATION
PACKING
25kgs in Fiber Drum
HAZARD CLASS Not regulated
UN NO.  
PRICE INFORMATION