L-LEUCINE

PRODUCT IDENTIFICATION
CAS NO. 61-90-5

L-LEUCINE

EINECS NO.

200-522-0

FORMULA C6H13NO2
MOL WT. 131.17

H.S. CODE

 2922.49

TOXICITY

 
SYNONYMS H-Leu-OH; L-2-Amino-4-methylpentanoic acid;
2-amino-4-methylvaleric acid; 2-Amino-4-methylpentanoic acid; (S)-(-)-Leucine; (2S)-alpha-2-amino-4-methylvaleric acid; (2S)-alpha-Leucine; L; L-Leu; L-(-)-leucine; L-Leucine;
SMILES  

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white crystals

MELTING POINT 286 - 288 C
BOILING POINT Decomposes
SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions. Moisture, light sensitive.

GENERAL DESCRIPTION
Valine, Isoleucine and Leucine are all branched-chain amino acids which can be burned for fuel in the cells to promotes muscle recovery when in balance with each other most effective. Only the L-stereoisomers appear in mammalian protein. They play a role in wound healing and the growth of new tissue. These branched amino-acids are needed to increase the bio-availability of complex carbohydrate intake and are absorbed by the muscle cells for anabolic muscle building activity. Branched amino-acids (Valine, Isoleucine and Leucine ) with tryptophan and phenylalanine (aromatic side chain amino acids) contribute to the structure of protein by the tendency of its side chain composed only of carbon and hydrogen to participate in hydrophobic interactions which determines the tertiary structure of the peptide chain. Isoleucine, chemically 2-amino-3-methylvaleric acid, is a monocarboxylic amino acid occurring in most dietary proteins. It is necessary for optimal growth in infants and for nitrogen equilibrium in human adults. Leucine, chemically 2-amino-4-methylvaleric acid, is the isomer of isoleucine. Their methyl branch positions are difference, which show different properties of them. Norleucine, chemically 2-aminohexanoic acid, is the unbranched isomer.  The prefix nor- describes normal structure which has no branched chain of carbon atoms. (In case of norepinephrine, it has one less methylene group than its homologue, epinephrine). Norleucine is a nonessential amino acid extracted from the leucine fraction of the decomposition of the proteins of nervous tissue. Commercial norleucine is synthesized for peptidomimetics to prepare unnatural and unusual amino acids and amino acid analogs as well as to modify peptides.
SALES SPECIFICATION

APPEARANCE

white crystals
ASSAY

98.5 - 101.0%

SPECIFIC ROTATION

+14.5° ~ +16.5° (C=2 in 5N HCl)

LOSS ON DRYING

0.2% max

RESIDUE ON IGNITION

0.1% max

CHLORIDE

0.02% max

SULFATE

0.03% max

HEAVY METALS

10ppm max

IRON

10ppm max

ARSENIC

1ppm max

AMMONIUM SALTS

0.02% max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 24/25

GENERAL PROPERTIES OF AMINO ACIDS

Amino Acid

Abbreviation

Formula (Mol WT)

pK1

pK2

pKR

pI

Hydropathy Index

3-Letters

1-Letter

-COOH

-NH3+

R group
Alanine

Ala

A

 C3H7NO2 (89.09)

2.34

9.69

-

6.00

1.8
Arginine

Arg

R

 C6H14N4O2(174.20)

2.17

9.04

12.48

10.76

-4.5
Asparagine

Asn

N

 C4H8N2O3(132.12)

2.02

8.80

-

5.41

-3.5
Aspartic Acid

Asp

D

 C4H7NO4(133.10)

1.88

9.60

3.65

2.77

-3.5
Cysteine

Cys

C

 C3H7NO2S(240.30)

1.96

10.128

8.18

5.07

2.5
Glutamic Acid

Glu

E

 C5H9NO4(147.13)

2.19

9.67

4.25

3.22

-3.5
Glutamine

Gln

Q

 C5H10N2O3(146.15)

2.17

9.13

-

5.65

-3.5
Glycine

Gly

G

 C2H5O2(75.07)

2.34

9.60

-

5.97

-0.4
Histidine

His

H

 C6H9N3O2(155.16)

1.82

9.17

6.00

7.59

-3.2
Isoleucine

Ile

I

 C6H13NO2(131.18)

2.36

9.60

-

6.02

4.5
Leucine

Leu

L

 C6H13NO2(131.18)

2.36

9.60

-

5.98

3.8
Lysine

Lys

K

 C6H14N2O2(146.19)

2.18

8.95

10.53

9.74

-3.9
Methionine

Met

M

 C5H11NO2S(149.21)

2.28

9.21

-

5.74

1.9
Phenylalanine

Phe

F

 C9H11NO2(165.19)

1.83

9.13

-

5.48

2.8
Proline

Pro

P

 C5H9NO2(115.13)

1.99

10.60

-

6.30

1.6
Serine

Ser

S

 C3H7NO3(105.19)

2.21

9.15

-

5.58

-0.8
Threonine

Thr

T

 C4H9NO3(119.12)

2.09

9.10

-

5.60

-0.7
Tryptophan

Trp

W

 C11H10N2O2(204.23)

2.83

9.39

-

5.89

-0.9
Tyrosine

Tyr

Y

 C9H11NO3(181.19)

2.20

9.11

10.07

5.66

-1.3
Valine

Val

V

 C5H11NO2(117.15)

2.32

9.62

-

5.96

4.2