HESPERIDIN (VITAMIN P)

HESPERIDIN

PRODUCT IDENTIFICATION

CAS NO.

520-26-3

HESPERIDIN

EINECS NO.

208-288-1

FORMULA C₂₈H₃₄O₁₅

MOL WT. 610.57

H.S. CODE

TOXICITY

SYNONYMS Hesperidoside; Cirantin;

Hesperitin-7-rutinoside; Hesperitin-7-rhamnoglucoside; Hesperetin 7-rutinoside; Hesperetin 7-rhamnoglucoside; (S)-7-[[6-O-(6-deoxy- alpha-L-mannopyranosyl)- beta-D-glucopyranosyl]oxy]- 2,3-dihydro-5-hydroxy- 2-(3-hydroxy-4-methoxyphenyl)-4H-1-Benzopyran-4-one; Cirantin; Hesperetin-7 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-Glucopyranoside; Vitamin P; 7-((6-O-(6-Deoxy-alpha- L-mannopyranosyl)-beta-D- glucopyranosyl)oxy)-2,3-dihydro- 5-hydroxy-2-(3- hydroxy-4- methoxyphenyl)- 4H-1-benzopyran-4-one; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 7-((6-O-alpha-L-rhamnopyranosyl- beta- D-glucopyranosyl)oxy)-4-chromanon; Other CAS RN: 106904-63-6; 15512-51-3; 16643-24-6; 17654-22-7; 28283-75-2; 30927-97-0; 32737-61-4;

DERIVATION

CLASSIFICATION

VITAMINS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellow powder

MELTING POINT 257 - 262 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER Soluble

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions. Hygroscopic, light sensitive.

GENERAL DESCRIPTION & APPLICATIONS

Hesperidin, a polyphenolic bioflavonoid, is a water-soluble pigment synthesized or naturally occurring as a glycoside in orange peel or other citrus fruits. It, chemically (S)-7-[[6-O-( 6-deoxy- alpha-L-mannopyranosyl )- beta-D-glucopyranosyl] oxy]- 2,3-dihydro-5-hydroxy- 2-( 3-hydroxy-4-methoxyphenyl )-4H-1-Benzopyran-4-one, is a white to yellow crystalline powder melting at ca 260 C. Bioflavonoids are called phytochemicals, Vitamin P, and Vitamin C2. There are about 2000 known bioflavonoids including catechin, citrin, eriodictin, hesperetin, hesperidin, nobiletin, quercetin, rutin, sinensetin, and tangeretin. Vitamin P is not a dietary essential but is known to have the effect on capillary disorders. It increases the strength of the walls of the blood capillaries and regulates their permeability. It may have an contribution to the total antioxidant activity and detoxifiers. It may enhance the action of Vitamin C. It is considered that it lowers down cholesterol levels if it taken with Vitamin C. It is also know to have pharmacological action as an anti-inflammatory ,antihistaminic and antiviral agent. Hesperidin is the predominant flavonoid in lemons and sweet oranges.

Rutin, the glycoside form of quercetin, is a bioflavonol having aromatic trimeric heterocyclic structure. It is a naturally occurring pigment. It, chemically 3-[[6-O-(6-deoxy-alpha-L- mannopyranosyl )-beta-D-glucopyranosyl] oxy]-2- (3,4-dihydroxyphenyl) -5,7-dihydroxy-4H- 1-Benzopyran-4-one, is a yellow to greenish crystalline powder melting at 190 C. Rutin is classified as vitamin P which increases the strength of the walls of the blood capillaries and regulates their permeability. Others classified as vitamin P are catechin, citrin, eriodictin, hesperetin, hesperidin, nobiletin, quercetin, sinensetin, and tangeretin. It is not a dietary essential but is known to have the effect on capillary disorders. It may also have an contribution to the total antioxidant activity and detoxifiers. It is also know to have pharmacological action as an anti-inflammatory ,antihistaminic and antiviral agent.

Members of rutin molecules

Product	CAS RN
Rutinose	90-74-4
Rutin	153-18-4
Hesperidin	520-26-3
Narcissin	604-80-8
Tetra(hydroxyethyl)rutoside	6980-20-7
Troxerutin	7085-55-4
Ascorutin	8067-12-7
Rutin sodium sulfate	12768-44-4
Eriocitrin	13463-28-0
Narirutin	14259-46-2
Tamarixetin 7-rutinoside	14265-53-3
Delphinidin-3-rutinoside	15674-58-5
Kaempferol 7-neohesperidoside	17353-03-6
Keracyanin	18719-76-1
Monoxerutin	23869-24-1
Veronicastroside	25694-72-8
Ethoxazorutoside	30851-76-4
Isorhamnetin-3-O-rutinoside-7-O-glucoside	55481-91-9
Rutin S	64755-26-6
Diethanolamine-rutin	69344-84-9
Rutin-N-mustard	85625-48-5
Nirurin	96253-68-8
Rutin sulfate	108916-86-5
Isorhamnetin-3-O-rutinoside-4'-O-glucoside	111393-97-6
Violdelphin	126417-59-2
Swertiamacroside	128585-97-7
D-Glucose-rutin	130603-71-3
Rutin butyryl ester	131981-32-3
2',5,5',7-Tetrahydroxy-flavanone-7-O-rutinoside	153286-43-2
Rutin hydrate	207671-50-9
Rutin trihydrate	250249-75-3

SALES SPECIFICATION

APPEARANCE

yellow powder

ASSAY

93.0% - 98.0 %

IDENTIFICATION

Pass

OPTICAL ROTATION

-65° ~ -70° (C=2 Pyridine)

LOSS ON DRYING

5.0% max

QUERCETIN

5.0% max

HEAVY METALS

10ppm max

TRANSPORTATION

PACKING 25kgs in fiber drum

HAZARD CLASS not regulated

UN NO.

OTHER INFORMATION

Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 24/25/28A/37/45 Other CAS RN:106904-63-6; 15512-51-3; 16643-24-6; 17654-22-7; 28283-75-2; 30927-97-0; 32737-61-4

GENERAL DESCRIPTION OF FLAVONOID

Flavonoid is any member of a class of widely distributed biological natural products containing aromatic heterocyclic skeleton of flavan (2-Phenylbenzopyran) but no nitrogen in plants. Generally, flavonoids are biological pigments providing colours from red to blue in flowers, fruit and leaves. Besides their coloring in plants, flavonoids have important roles in the growth and development of plants; protection against UV-B radiation; forming antifungal barriers; antimicrobial, insecticidal and oestrogenic activities; plant reproduction. Flavonoids also exhibit a wide range of biological properties including anti-microbial, insecticidal and oestrogenic activities. Flavonoids are usually classified into main 6 subgroups as below plus flavans, neoflavonoids, flavonols, aurons, catechins according to the structural patterns.

Flavonols (Hydroxy derivatives of flavone): Fisetin, Galangin, Kaempferide, Kaempferol, Morin, Myricetin, Myricitrin, Quercetin, Quercetrin, Rhamnetin, Robinin, Rutin, Spirenoside
Flavones (skeleton: 2-phenylchromen-4-one): Apigenin, Baicalein, Chrysin, Diosmetin, Diosmin, Flavone, Luteolin, Rpoifolin,Tangeretin, Techtochrysin, Rhamnazin, Nobiletin, Natsudaidain.
Isoflavones (skeleton: 3-phenylchromen-4-one): Daidzin, Genistein, Irilone, Luteone, Prunetin, Pratensein,
Flavonones (derivation by reduction of the 2(3) C=C bond): Eriodictyol, Hesperidin, Hesperetin, Likvirtin, Naringin; Naringenin; Pinocembrin
Flavanols (derivation by reduction of the keto group):(+)-Catechin, (+)-Gallocatechin, (-)-Epicatechin (EC), (-)-Epigallocatechin (EGC), (-)-Epicatechin 3-gallate (ECG), (-)-Epigallocatechin 3-gallate (EGCG), Theaflavin, Theaflavin 3-gallate, Theaflavin 3'-gallate, Theaflavin 3,3' digallate, Thearubigins
Anthocyanidins (aglycones of the glycoside anthocyanins): Apigeninidin, Cyanidin, Delphinidin, Diosmetinidin, Guibourtinidin, Fisetinidin, Luteolinidin, Malvidin, Pelargonidin, Peonidin, Robinetinidin, Tricetinidin, Capensinidin, Petunidin, Europinidin, Aurentinidin, Columnidin, 5-Desoxy-malvidin, 5-Desoxy-peonidin, Hirsutinidin, Rosinidin

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