PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

c1(ccccc1)OC(=O)Cl

CLASSIFICATION

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

REFRACTIVE INDEX

560 C

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Phosgene

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Phenyl chloroformate

PubChem Compound Summary - Phenyl chloroformate

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Phenyl chloroformate

http://www.ebi.ac.uk/ -  Phenyl chloroformate

http://www.ncbi.nlm.nih.gov/ -  Phenyl chloroformate

Material Safety Data Sheet

Local:
Phosgene (carbonyl dichloride, COCl₂) is a very reactive chemical intermediate to prepare isocyanates (from amines), chloroformates, isothiocyanates, isonitriles and acid chlorides (from carboxylic acids) as well as in the production of polymers including polyurethanes, polycarbonates, and polyureas. Phosgene , however, is extremely toxic gas associated strong safety hazards and handling precautions. It is listed on schedule 3 of the Chemical Weapons Convention. All production sites must be declared to the OPCW. Phosgene is almost entirely in captive consume in the production plant.

Chloroformates are relatively less dangerous route to prepare important families of compounds, the carbonates and carbamates. Carbonates are prepared by reaction with alcohol (or phenol) and carbamates are by reaction with an amine ( primary or secondary). Chloroformates are starting materials to prepare carbonate and carbamate derivatives that are used in the pharmaceutical and agrochemical industry.

Phenyl chloroformate is used as an intermediate for the synthesis of pharmaceuticals and agrochemicals especially for some carbamates (salt or ester of an amide of carbonic acid) which are used as insecticides, fungicides, herbicides, sprout inhibitors and biocides.

APPEARANCE

ASSAY

98.0% min

COLOR, APHA

30 max

CARBONATE

0.5% max 

PHOSGENE

0.5% max 

IRON

2ppm max

PHENOL

0.5% max 

HCl

0.5% max

HAZARD OVERVIEW

Water reactive. Contact with water liberates toxic gas. May be fatal if inhaled. Harmful if swallowed. Causes burns by all exposure routes. May cause an allergic skin reaction. The substance decomposes on heating or on contact with water or moisture producing toxic and corrosive fumes including hydrogen chloride and phenol. Reacts violently with acids , alcohols , amines , bases , oxidants and metals.

GHS

PICTOGRAMS

HAZARD STATEMENTS

H314-H335-H350-H410

P STATEMENTS

P201-P261-P273-P280-P305 + P351 + P338-P310

RISK PHRASES

22-26-34

SAFETY PHRASES

26-28-36/37/39-45