PRODUCT IDENTIFICATION

H.S.CODE

TOXICITY

1H-Indole-3-methanol; 3-Indolylcarbinol; 3-Indolylmethanol; Indole-3-carbinol;

c12c([nH]cc1CO)cccc2

CLASSIFICATION

Alkaloid, Antioxidant, Auxin

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

SOLVENT SOLUBILITY

REFRACTIVE INDEX

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Wikipedia Linking - Auxin

Google Scholar Search - Indole-3-carbinol

Drug Information Portal (U.S. National Library of Medicine) - Indole-3-carbinol

PubChem Compound Summary - Indole-3-carbinol

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Indole-3-carbinol

http://www.ebi.ac.uk/ - Indole-3-carbinol

http://www.ncbi.nlm.nih.gov/ - Indole-3-carbinol

Local:
Indole, benzopyrrole, is a yellow crystalline powder with unpleasant aroma. It has the pyrrole ring (five-membered unsaturated ring structure composed of four carbon atoms and one nitrogen atom) which is fused to benzene ring. There are tautomerer called indolenine (unsubstituted 3H-indole) and structural isomer, isoindole. But they are unstable. Indole occurs in some plants or in coal tar, and is formed in the intestine during putrefaction and by certain cultures of bacteria. it is commercially synthesized from phenylhydrazine and pyruvic acid.  Indole structure is a motif in nature. Prominent examples include tryptophan (aromatic side chain amino acid), serotonin (neurotransmitter), auxin (plant growth hormone), and indigo (plant colorant). One more interesting point is all these compounds have functional branches at 3 position. Indole is used in perfumery and in preparing tryptophan, one of the 20 amino acids commonly found in animal proteins. It has important application in the industry of plant growth. It is used to prepare indoleacetic acid (auxin) and other plant growth substances which help the development of roots in plant. It is used to make selective herbicides. Indole and its derivatives are widely used in making perfumes, dyes, agrochemicals and medicines.  Indole-3-carbinol, found in cruciferous vegetables, is used as a dietary supplement and to make pharmaceuticals especially for anticancer drugs. It is known to inhibit cancinogenesis at the initiation stage in several animal species. But it enhances tumor incidence if administered at a post-initiation stage. It is known to lower down cholesterol.

APPEARANCE

IDENTIFICATION

Complies related spectrum

ASSAY

98.5 - 101.5%

LOSS ON DRYING

1.0% max

HAZARD OVERVIEW

May cause eye and skin irritation. May cause respiratory and digestive tract irritation. Target Organs: None.

GHS

PICTOGRAMS

HAZARD STATEMENTS

H315-H319

P STATEMENTS

P305 + P351 + P338

RISK PHRASES

36/38

SAFETY PHRASES

26-36