CLOFIBRIC ACID

PRODUCT IDENTIFICATION
CAS NO. 882-09-7

Clofibric acid

EINECS NO. 212-925-9
FORMULAClC6H4OC(CH3)2COOH
MOL WT. 214.65

H.S. CODE

2918.99.4300

TOXICITY

  
SYNONYMS 2-(p-Chlorophenoxy)-2-methylpropionic acid;
R-(+)-2-(4-Chloro-2-methylphenoxy)propionic acid; 2-(p-Chlorphenoxy)- 2-methylpropionsäure (Dutch); ácido 2-(p-clorofenoxi)- 2-metilpropionico (Spanish); Acide 2-(p-chlorophénoxy)-2-méthylpropionique (French); 2-(4-Chlorophenoxy)-2-methylpropionic acid; 2-(p-Chlorophenoxy)isobutyric acid; Acidum chlorphibricum; Acidum clofibricum; Chlorfibrinic acid; Chlorofibrinic acid; Chlorophibrinic acid; Clofibrate free acid; Clofibrinsaeure; alpha-(4-(Chlorphenoxy)-2-methylpropionsaeure; alpha-(4-Chlorophenoxy)-alpha-methylpropionic acid; alpha-(4-Chlorophenoxy)isobutyric acid; alpha-(p-Chlorophenoxy)isobutyric acid; p-(2,4-Chlorophenoxy)isobutyric acid;
SMILES

C(Oc1ccc(Cl)cc1)(C)(C(O)=O)C

CLASSIFICATION

Anticholesteremic, Antilipemic, Hypolipidemic, Lipid Regulating Agent

EXTRA NOTES

 An antilipemic agent that is the biologically active metabolite of clofibrate.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White to off-white crystalline powder
MELTING POINT 120 - 122 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 583 mg/l
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health hazard: 1, Fire: 0, Reactivity Hazard: 0 

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Clofibric acid

Google Scholar Search - Clofibric acid

Drug Information Portal (U.S. National Library of Medicine) - Clofibric acid

PubChem Compound Summary - Clofibric acid

IPCS INCHEM -  Clofibrate

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Clofibric acid

http://www.ebi.ac.uk/ - Clofibric acid

http://www.ncbi.nlm.nih.gov/ - Clofibric acid

Material Safety Data Sheet

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Clofibric acid

Local:
Auxin is one of five (or more) major plant hormones (Auxin, Cytokinins, Gibberellins, Ethylene and Abscisic acid) which affect numerous plant growth processes functions including cell division and elongation, autumnal loss of leaves, and the formation of buds, roots, flowers, and fruit. Auxin action is inhibited by light which is an important role of the growth of stems toward light (phototropism), against the force of gravity (geotropism) and positively hydrotropic (moisture-seeking). The cells exposed to light don't grow as quickly as those on the shaded side, and thus the plant grows toward the light source. Auxins usually have a ring system with at least one double bond and attached by a side-chain that terminates in a carboxyl group. Indole acetic acid is the exact structure of Auxin activity. Other parent compounds of auxin action are;

  • Auxins
    • 4-Chlorophenoxyacetic acid (CAS RN: 122-88-3)
    • (2,4-Dichlorophenoxy)acetic acid (CAS RN: 94-75-7)
    • 4-(2,4-Dichlorophenoxy)butyric acid (CAS RN: 94-82-6)
    • Tris[2-(2,4-Dichlorophenoxy)ethyl] phosphite (CAS RN: 94-84-8)
    • 2-(2,4-Dichlorophenoxy)propanoic acid (CAS RN: 120-36-5)
    • 2-(2,4,5-trichlorophenoxy)propanoic acid (CAS RN: 93-72-1)
    • Indole-3-acetic acid (CAS RN: 87-51-4)
    • Indole-3-butyric acid (CAS RN: 133-32-4)
    • 1-Naphthaleneacetamide (CAS RN: 86-86-2)
    • 1-Naphthaleneacetic acid (CAS RN: 86-87-3)
    • 1-Naphthol (CAS RN: 90-15-3)
    • Naphthoxy acetic acid (CAS RN: 120-23-0)
    • Naphthenic acid, inorganic salts (potassium, sodium)
    • (2,4,5-Trichlorophenoxy) Acetic acid (CAS RN: 93-76-5)
  • Antiauxins
    • Clofibric acid (CAS RN: 882-09-7)
    • 2,3,5-Triiodobenzoic acid (CAS RN: 88-82-4)

Clofibric acid is the intermedaite to produce clofibrate, an antihyperlipidemic agent to reduce elevated serum lipids.
SALES SPECIFICATION

APPEARANCE

 White to off-white crystalline powder

ASSAY

98.0% min

WATER

1.0% max

p-CHLOROPHEOL

0.1% max

SULFATE

0.2% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

Harmful by ingestion. 

GHS

 
SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H302

P STATEMENTS

P280-P301 + P310

EC DIRECTIVES

 
HAZARD CODES

RISK PHRASES

22

SAFETY PHRASES

36

PRICE INFORMATION