NEOMYCIN SULFATE

NEOMYCIN SULFATE

PRODUCT IDENTIFICATION

CAS NO.

1404-04-2, 1405-10-3 (sulfate), 119-04-0 (B form)

EINECS NO. 215-773-1

FORMULA C₂₃H₄₆N₆O₁₃(B form)

MOL WT. 614.65

H.S. CODE

TOXICITY

SYNONYMS Fradiomycin B; Neomycin B; Streptothricin B;

2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-5-O-[3-O- (2,6-diamino-2,6- dideoxy- beta-L-idopyranosyl)-bete-D-ribofuranosyl]-D-streptamine; 4,6-diamino-2-{[3-O- (2,6-diamino- 2,6- dideoxyhexopyranosyl) pentofuranosyl]oxy}-3- hydroxycyclohexyl-2,6- diamino-2,6-dideoxyhexo pyranoside

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish powder

MELTING POINT

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Aminoglycoside is any of a group of antibiotics derived from various species of Streptomyces or Micromonosporaceae, while some of which are produced synthetically. Aminoglycosides inhibit bacterial protein synthesis by binding with the 30S ribosomal subunit. They include;

Aminoglycoside antibiotic

CAS RN.

Adechlorin 96328-17-5

Gentamicin 1403-66-3

Netilmicin
56391-56-1

Gentamicin sulfate 1405-41-0

Amikacin 37517-28-5

Apramycin 37321-09-8

Butirosin sulfate anhydrous 51022-98-1

Chlorothricin 34707-92-1

Dibekacin 34493-98-6

Dihydrostreptomycin Sulfate 5490-27-7

Framycetin 119-04-0

Geneticin 49863-47-0

Hygromycin A 6379-56-2

Hygromycin B 31282-04-9

Isepamicin 58152-03-7

Kanamycin 59-01-8

Nebramycin 11048-13-8

Neomycin 1404-04-2

O-Demethylchlorothricin 134637-04-0

O-Demethylhydroxychlorothricin 134615-17-1

Paromomycin 7542-37-2

Puromycin

53-79-2

Ribostamycin 25546-65-0

Sisomicin 32385-11-8

Streptomycin 57-92-1

Streptozocin 18883-66-4

Tobramycin sulfate 49842-07-1

Tobramycin 32986-56-4

Neomycin is an aminoglycoside antibiotic derived from the metabolic Streptomyces fradiae, effective against a wide range of aerobic gram-negative bacilli and some gram-positive bacteria. It consists of three components A, B, and C. The main form is B, The chemical designation is 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-5-O-(3-O- (2,6-diamino-2,6-dideoxy- beta-L-idopyranosyl)-bete-D-ribofuranosyl)-D-streptamine. Neomycin is applied topically to the skin, conjunctiva, and ears in the treatment of infections due to susceptible organisms. It is used in combination with other antibiotics or antiinflammatory steroids. Neomycin sulfate is administered orally in preoperative bowel preparation. Neomycin sulfate is a white to yellowish powder; hygroscopic; very soluble in water; slightly soluble in alcohol; insoluble in acetone.

Neomycin and Framycetin are not absorbed from the gastrointestinal tract and are thusfound in many topical medications such as creams, ointments and eyedrops. They can also be used for gastrointestinal infections. Framycetin yields neamine and neobiosamine B on hydrolysis.

Neomycin analogues or derivatives;

Product	CAS RN.
Neomycin C	66-86-4
Framycetin	119-04-0
Fradicin	1403-61-8
Neomycin	1404-04-2
Bacitracin	1405-87-4
Neomycin sulfate	1405-10-3
Neomycin, hydrochloride	1406-02-6
Neomycin undecylenate	1406-04-8
Streptonigrin	3930-19-6
Neamine	3947-65-7
Paromomycin	7542-37-2
Predni aquos opthiole	8024-67-7
Cortisporin	8024-64-4
Synalar N	8025-20-5
Nebacetin	8025-63-6
Cicatrin	8055-43-4
Mixture (neomycin, polymyxin, bacitracin)	8057-37-2
Neoterramycin	8057-00-9
Proctosedyl	8058-05-7
Vibrocil	8059-14-1
Pimafucort	8072-88-6
Hexasalicylideneneomycin	11041-92-2
Neomycin B hydrochloride	25389-99-5
Ribostamycin	25546-65-0
Neomycin B sulfate	28002-70-2
3'-O-Methylneamine	37085-86-2
4'-O-Methylneamine	37085-87-3
1-N-(s)-4-Amino-2-hydroxybutyryl-3'4'-deoxyneamine	42859-94-9
Butirosamine	50474-68-5
Mixture (neomycin, polymyxin)	51273-62-2
Statrol	51484-67-4
Neomycin F	51795-47-2
Polyspectrin	52218-57-2
Diaropect	52503-65-8
Betnovate-N	53262-69-4
Neomycin B-glucoside	53861-54-4
L-N(sup 1)-(4-Amino-2-hydroxybutyryl)-4'-deoxyneomycin A	54333-80-1
4'-Deoxy-5-O-xylosylneamine	54333-81-2
Neomycin palmitate	55298-68-5
Ribosylparomamine	55781-25-4
Dodeca-N-methylneomycin hexamethochloride	57270-93-6
Dimethylaminopropylneomycin	57285-81-1
Tresaderm	57571-74-1
Kanamycin phosphotransferase II	58943-39-8
Neomycin C hydrochloride	63121-20-0
Neomycin 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid	71750-54-4
Cysto-myacyne	76391-80-5
Dontisolon	76403-99-1
Framycort	77536-65-3
Neomycin-pantothenate	78149-94-7
Vineomycin A1	78164-00-8
neomedrol-veriderm	78232-14-1
Neo-medrol	78232-16-3
Oterna	78371-70-7
Pulpomixine	78515-94-3
6'''-Deamino-6'''-hydroxyparomomycin I	78524-72-8
6'''-Deamino-6'''-hydroxyneomycin B	78524-73-9
Maxitrol	78666-15-6
Mixture(neomycin, nystatin, polymyxin, acetarsol, dimethicone)	78891-94-8
Sofradex	79173-16-3
3',4'-dideoxyparomomycin	80451-74-7
Vineomycin B2	80928-52-5
Vineomycin B1	81457-63-8
Vineomycin A2	81457-62-7
Trofodermin	84057-92-1
Dansylparomomycin	85166-09-2
Neotil	85883-86-9
Panotile	99401-18-0
3-N-methylparomomycin I	106288-50-0
Polyspectran OS	117733-87-6
Mixture(colistin sulfate, neomycin sulfate, hydrocortisone acetate, thonzonium bromide)	119509-48-7
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione neomycin sulfate / polymyxin sulfate	123354-95-0
Fokalmin	126663-41-0
Dexapolyspectran	143305-95-7

SALES SPECIFICATION

APPEARANCE

white to yellowish powder

ASSAY

680 μm/mg min (Anhydrous potency)

IDENTIFICATION

positive (Test A, Test B,)

SULFATE

27.0 - 31.0%

STREPTOMYCIN B

3.0% max

5.0 - 7.0

RELATED SUBSTANCES

Neomycin C: 3.0 - 15.0%
Neamine : 2.0% max
Total Impurity: 15.0% max

LOSS ON DRYING

8.0% max

OPTICAL ROTATION

+53.5º ~ +59.0º

SULFATED ASH

1.0% max

RESIDUE ON IGNITION

1.0% max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

PRICE INFORMATION