IOHEXOL

PRODUCT IDENTIFICATION
CAS NO. 66108-95-0

IOHEXOL

EINECS NO. 266-164-2
FORMULA C19H26I3N3O9
MOL WT. 821.14

H.S. CODE

  

TOXICITY

  
SYNONYMS Omnipaque; Exypaque;
N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide; 5-(Acetyl(2,3-dihydroxypropyl)amino)-N,N'-bis(2,3- dihydroxypropyl)- 2,4,6-triiodo-1,3- benzenedicarboxamide;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER
soluble
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 

FLASH POINT  
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Contrast media is a substance that is introduced into or around a structure or tissues to produce the visualization of organs and certain tissues under the absorption of x-rays. In diagnostic radiology the purpose is to detect and to treat certain diseases. Nonionizing radiations of infrared, gamma rays, ultrasound waves, and magnetic fields are also used for diagnosis. MRI contrast agents work by altering the magnetic properties of hydrogen nucleus not by radioopaque. Barium sulfate class contrast agents are used in the digestive tract. Organic iodine contrast agents are water soluble and less harmful to the body, and thus can be used almost anywhere in the body. Examples of contrast medium used in diagnostic radiology include;

Radiopaque Medium

CAS RN.

Phenylephrine hydrochloride

61-76-7
Iopanoic acid 96-83-3
Diatrizoic acid 117-96-4
Diatrizoate Meglumine 131-49-7
Iodamide 440-58-4
Propyliodone 587-61-1
Diatrizoate Sodium 737-31-5
Ipodate Calcium 1151-11-7
Oxidopamine 1199-18-4
Ipodate Sodium 1221-56-3
Iothalamate Sodium 1225-20-3
Iophendylate 1320-11-2
Ioprocemic acid 1456-52-6
Iothalamic acid 2276-90-6
Ioglycamic acid 2618-25-9
Iobenzamic acid 3115-05-7
Iodipamide Meglumine 3521-84-4
Iopydol 5579-92-0
Iopydone 5579-93-1
Iosefamic acid 5591-33-3
Meglumine 6284-40-8
Metrizoate Sodium 7225-61-8
Tyropanoate Sodium 7246-21-1
Barium sulfate 7727-43-7
Ethiodized Oil 8008-53-5
Iocarmic acid 10397-75-8
Iothalamate Meglumine 13087-53-1

Iothalamate sodium I 131

 15845-98-4
Iocetamic acid 16034-77-8
Iothalamate sodium I 125 17692-74-9
Iodamide Meglumine 18656-21-8
Ioxotrizoic acid 19863-06-0
Metrizamide 31112-62-6
Iodoxamic acid 31127-82-9
Iopronic acid 37723-78-7
Iosumetic acid 37863-70-0
Gallium citrate 41183-64-6
Ioglicic acid 49755-67-1
Iotroxic acid 51022-74-3
Iodoxamate Meglumine 51764-33-1
Ioseric acid 51876-99-4
Iocarmate Meglumine 54605-45-7
Thallous chloride 55172-29-7
Ioxaglic acid 59017-64-0
Ioxaglate meglumine 59018-13-2
Iotetric acid 60019-19-4
Iopamidol 60166-93-0
Iosulamide Meglumine 63534-64-5
Ioglucol 63941-73-1
Ioglucomide 63941-74-2
Iohexol 66108-95-0
Ioxaglate sodium 67992-58-9
Iotasul 71767-13-0
Iopromide 73334-07-3
Iogulamide 75751-89-2
Iomeprol 78649-41-9
Iotrolan 79770-24-4
Ioversol 87771-40-2
Iopentol 89797-00-2
Iodixanol 92339-11-2
Technetium TC 99m teboroxime 104716-22-5
Technetium TC 99m sestamibi 109581-73-9

Iohexol [N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide] is a non-ionic, water-soluble, low-osmolality contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures; administered by intrathecal or intravascular injection.

Closely related substance with Iohexol is Iodixanol [5,5'-((2-Hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophthalamide) is a dimeric, nonionic, water-soluble, iso-osmolar contrast agent.

SALES SPECIFICATION

APPEARANCE

 white powder
IDENTIFICATION

Passes test A, B
ASSAY

98.0 - 102.0%

SPECIFIC ROTATION

-0.5° ~ +0.5°
IONIC COMPOUNDS

0.1% max
FREE IODIDE

10ppm max
RESIDUE ON IGNITION

0.1% max
FREE AMINES

0.04% max

METHANOL

0.005% max
ALCOHOL TOTAL

0.01% max

BACTERIAL EUDOTOXINS

 0.001EU/mgI max
HEAVY METALS

10ppm max
ABSORBANCE

400nm: 0.18 max
420nm: 0.03 max
450nm: ≤ 0.015 max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
PRICE
5kgs - U$2,500.-