EPHEDRINE SULFATE

PRODUCT IDENTIFICATION
CAS NO.

299-42-3 (Base)
134-72-5 (Sulfate)

EPHEDRINE SULFATE
EINECS NO. 206-080-5, 205-154-4
FORMULA (C10H15NO)2·H2SO4
MOL WT. 428.54

H.S. CODE

  

TOXICITY

  
SYNONYMS (-)-ephedrine sulfate; (-)-ephedrine sulfate (2:1) (salt);
1-alpha-(1-(methylamino)ethyl)benzyl alcohol sulfate; 1-phenyl-2-methylamino-propanol-1-sulfate; 1-Phenyl-2-(methylamino)propanol sulfate; L-ephedrine sulfate; alpha-[1-(methylamino) ethyl] benzenemethanol sulfate (2:1) (salt); (R-(R',S'))-alpha-(1-(methylamino)ethyl)benzenemethanol sulfate (2:1) (salt); Bis[[R-(R',S')]-beta-hydroxy-alpha-methylphenethyl)methylammonium] sulphate;
DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white crystalline powder
MELTING POINT 248 - 252 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble (slightly soluble in EtOH, insoluble in ether)
pH 4.5 - 7
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY

Stable under ordinary conditions. Light sensitive.

GENERAL DESCRIPTION & APPLICATIONS
Ephedrine is a sympathomimetic alkaloid originally obtained from species of Ephedra or prepared synthetically. Its action is similar to that of epinephrine (a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter). Its effects, although less powerful, are more prolonged, and it exerts action when administered orally, whereas epinephrine is effective only by injection. It is used as muscle relaxants, central nervous system and cardiac muscle stimulants in combination with others like theophylline. It is used to prevent hypotension during spinal and infiltration anesthesia; and as a mydriatic. There are enantiomers in ephedrine structure. (1R,2S)- and (1S,2R)-enantiomers are designated ephedrine (opposite stereoisomerisms around the chiral center), whereas (1R,2R)- and (1S,2S)-enantiomers are designated pseudoephedrine. Commercial ephedrine is (-)-(1R,2S)-ephedrine [also called (-)-Ephedrine or L-ephedrine], while commercial pseudoephedrine enantiomer is (1S,2S)-pseudoephedrine [(+)-pseudoephedrine or D-pseudoephedrine]. Pseudoephedrine has less press action and fewer central stimulant effects than ephedrine. Pseudoephedrine is used as a nasal decongestant and a bronchodilator to relaxe and open the air passages to the lung to increase the flow of air, and thus is used in the treatment and/or prevention of symptoms of bronchial asthma and of reversible bronchospasm associated with chronic bronchitis and emphysema.

EPHEDRINE MOLECULES
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SALES SPECIFICATION

APPEARANCE

white crystalline powder

IDENTIFICATION

passes test A,B
ASSAY

98.5.% - 101.5%

RELATED SUBSTANCE

Complies

OPTICAL ROTATION

-30.5° ~ -32.5° (C=5 in water)

VOLATILES

Complies

SOLVENT RESIDUE

Complies

HEAVY METALS

20ppm max
LOSS ON DRYING
0.5% max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 22-23

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Product

CAS RN.

Ephedrine Hydrochloride

50-98-6
Methamphetamine hydrochloride 51-57-0
Metaraminol 54-49-9
Amphetamine sulfate 60-13-9
Pseudoephedrine 90-82-4

Cinnamedrine

90-86-8
Racephedrine 90-81-3
Propylhexedrine 101-40-6
Racephedrine hydrochloride 134-71-4
Ephedrine sulfate 134-72-5
Nordefrin hydrochloride 138-61-4
Phenylpropanolamine hydrochloride 154-41-6

Ephedrine

299-42-3
Amphetamine 300-62-9
DL-Methamphetamine hydrochloride 300-42-5
(+)-Ephedrine anhydrous 321-98-2
(-)-Pseudoephedrine 321-97-1
Pseudoephedrine hydrochloride 345-78-8
Oxilofrine 365-26-4
Isoxsuprine 395-28-8
Nylidrin 447-41-6
Cathine 492-39-7
L-Phenylpropanolamine 492-41-1
Menetyl 530-35-8
Methamphetamine 537-46-2
p-Hydroxynorephedrine 552-85-2
Methylephedrine 552-79-4
Isoxsuprine hydrochloride 579-56-6
(-)-Pseudoephedrine hydrochloride 670-40-6
p-Hydroxynorephedrine 771-91-5
L-Methamphetamine hydrochloride 826-10-8
Carnigen 942-51-8
N-Methylephedrine hydrochloride 942-46-1
3,4-Dihydroxyephedrine hydrochloride 946-43-0
Norephedrine sulfate 1130-06-9
Norpseudoephedrine hydrochloride 2153-98-2
N-Acetylephedrine 2272-83-5
S-Ephedrine hydrochloride 2784-28-3
3-Hydroxyephedrine 3002-40-2
Cafedrine hydrochloride 3039-97-2
(-)-Norephedrine hydrochloride 3198-15-0
DL-Methamphetamine hydrochloride 4298-16-2
(-)-Norephedrine sulfate 5179-79-3
Metaraminol hydrochloride 5967-52-2
Phenylbutanolamine hydrochloride 6170-27-0
Nordefrin 6539-57-7
Ephedrine penicillin 7177-45-9
DL-Ephedrine phosphate 7234-09-5
Pseudoephedrine Sulfate 7460-12-0
DL-Methamphetamine 7632-10-2
Etafedrine 7681-79-0
(+)-Pseudoephedrine, benzoate hydrochloride 7699-91-4

Carnigen

8053-65-4

Actifed

8054-27-1

Nethaprin dospan

8056-81-3

Tedral

8057-98-5

Franol

8058-86-4
alpha-(1-(Isopropylamino)ethyl)-4-methylbenzyl alcohol 13549-60-5
3,4-Dihydroxy-N-isopropylnorephedrine 13725-13-8
Phenylpropanolamine 14838-15-4
N-Acetylephedrine 16413-75-5
Phenylephrine tartrate 17162-39-9
N-Methylephedrine 17605-71-9
N-Nitrosoephedrine 17608-59-2
N-Ethylnorpseudoephedrine 18259-40-0
DL-Methylephedrine hydrochloride 18760-80-0
4-Chloronorephedrine 23933-83-7
(+)-Ephedrine, hydrochloride 24221-86-1
1,4-Acetyldeoxyephedrine 34145-17-0
Norpseudoephedrine 36393-56-3
N-Diethylnorpseudoephedrine 37025-60-8
D-Phenylpropanolamine 37577-28-9
(-)-Methylephedrine hydrochloride 38455-90-2
N-Methacryloyl-L-ephedrine 38735-14-7
Ephedrine camphorsulphonate 38974-71-9
(+)-Norephedrine hydrochloride 40626-29-7
4-Chloronorpseudoephedrine 52373-27-0

Oxilofrin

52671-39-3

Asthmolysine

52756-53-3

1-Phenoxy-2-(N-methylpiperazino)-3-ephedrinopropane hydrochloride

53283-77-5
(-)-Norpseudoephedrine hydrochloride 53643-20-2

Efatin

53988-96-8
(+)-Methylephedrine hydrochloride 54114-10-2
Ephedrine phosphate 55340-64-2
DL-Pseudoephedrine hydrochloride 56979-55-6

Amesec

58933-57-6
Teasuprine 60640-79-1

N-Desmethylephedrine phosphate

63620-43-9
N-Desmethylephedrine phosphate 63620-43-9
O-Acetylephedrine 63950-97-0
L-m-Oxyephedrine hydrochloride 63991-21-9
o-Hydroxyephedrine 64038-76-2
D-Cinnamylephedrine 64043-53-4
DL-Cinnamylephedrine hydrochloride 64043-54-5
L-Cinnamylephedrine hydrochloride 64043-52-3
Cephedrine 67055-59-8
Ephedrine hydrogen sulfate 73986-87-5
Colchiceineamide-L-ephedrine phosphate 76109-92-7
Drixoral 76404-09-6

Linctifed

77944-85-5

Quadrinal

78515-92-1

Haymine

79861-91-9

Elsinore pill

79992-72-6

Midol

83514-22-1
Ephedrine thiocyanate 95141-03-0
S-S ephedrine hydrochloride 95697-03-3

Congesteze

98267-72-2
15-Cyclopentyl-7-oxo-prostaglandin I2-ephedrine 100992-40-3
7-Oxo-prostaglandin I2-ephedrine 108590-75-6

Seldane-D

123245-78-3
Loratadine mixture with pseudoephedrine sulfate 156098-07-6
1-Fluoro-1-deoxyephedrine 161403-39-0
N-Fluoroisopropylnorephedrine 176587-88-5