GLUTARIC ANHYDRIDE

PRODUCT IDENTIFICATION

CAS NO. 108-55-4

GLUTARIC ANHYDRIDE

EINECS NO. 203-593-6
FORMULA C5H6O3
MOL WT. 114.10
H.S. CODE  

TOXICITY

Oral rat LD50: 540 mg/kg
SYNONYMS Dihydro-2H-pyran-2,6(3H)-dione; Pentanedioic Anhydride;
Anhídrido glutarico (Spanish); Anhydride glutarique (French);

SMILES

 

CLASSIFICATION

CARBOXYLIC ACID ANHYDRIDES /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystals
MELTING POINT 50 - 55 C
BOILING POINT

150 C

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY Stable under ordinary conditions. Moisture sensitive

APPLICATIONS

Glutaric Anhydride is used in the production of glutaric acid family pharmaceuticals. Additional applications such as the production of polymers, corrosion inhibitors, surfactants and metal finishing compounds might be available.
SALES SPECIFICATION

APPEARANCE

white crystalline powder
ASSAY

97.0% min

WATER 0.1% max
MELTING POINT 50 - 55 C
TRANSPORTATION
PACKING 25kgs in fiber drum
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 21/22/36/37/38, Safety Phrases: 24/25/26

GENERAL DESCRIPTION OF ANHYDRIDE

Anhydride is a compound formed by the abstraction of a molecule of water, H2O, from a substance. The term acid anhydride is restricted sometime to the anhydride formed especially from an acid by dehydration or one that revert to the original substance upon hydration. In case of bimolecular, it can be composed of two molecules of the corresponding acid. The term mixed anhydride is an acid anhydride composed of two different acids. Examples are adenosine triphosphate or an aminoacyl adenylate. The anhydrides of bases are oxides.

Anhydrides of inorganic acids are usually oxides of nonmetallic elements. Carbon dioxide (CO2) is the anhydride of carbonic acid, dinitrogen pentoxide (N2O5) is the anhydride of nitric acid, sodium oxide is an anhydride of sodium hydroxide, phosphorus pentoxide (P2O5) is the anhydride of phosphoric acid, and sulfur trioxide (SO3) is the anhydride of sulfuric acid.  An acid anhydride forms an acid; a base anhydride forms a base. Sulfur trioxide (acid anhydride) reacts with water to form sulfuric acid (an acid product). Calcium oxide (an base anhydride) reacts with water to form calcium hydroxide (a base product).

Organic anhydrides contain the carbonyl group (CO). Organic anhydrides are formed by the condensation of original acids. Lactone, an internal cyclic monoester, is an anhydride derived from the hydroxyl and carboxyl radicals. In organic chemistry, most anhydride compounds are derived from corresponding carboxylic acids. Carboxylic anhydrides, general formula (RCO)2O, are the dehydration product of two carboxylic acid molecules. The name of carboxylic anhydride is given first from the original acid, followed by the separate word "anhydride". [CH3(CH2)2CO]2O is butanoic anhydride, CH3COOCOCH2CH3 is ethanoic propanoic anhydride (or acetic propionic anhydride). Anhydrides are more reactive than the parent acids. Anhydrides are typically not target molecules, but rather they are used as intermediates for the synthesis of other organic members such as esters and amides for the industrial applications include dyes, pharmaceuticals, pesticides, plastics, fibers, curing agents, plasticizers and many others. The reactivity of carboxylic acid derivatives are in order of acyl halides > anhydrides >> esters acids >> amides.  Anhydrides react with alcohols to form esters; acetic anhydride [(CH3CO)2O] reacts with ethanol (C2H5OH) to form ethyl acetate (CH3COOC2H5) used as a common solvent. Anhydrides also react with ammonia and primary or secondary amines to form amides. Anhydrides react with water to form their corresponding acids.