p-CRESIDINE

PRODUCT IDENTIFICATION
CAS NO. 120-71-8

p-Cresidine
EINECS NO. 204-419-1
FORMULA CH3OC6H3(CH3)NH2
MOL WT. 137.18
H.S. CODE

2922.29.8190

TOXICITY

 Oral rat LD50: 1450 mg/kg
SYNONYMS m-Amino-p-cresol methyl ester; meta-Amino-p-cresol methyl ether;
1-Amino-2-methoxy-5-methylbenzene; 2-Amino-4-methylanisole; 2-Methoxy-5-methylaniline; 2-Methoxy-5-methylbenzenamine; 3-Amino-4-methoxytoluene; 3-Amino-p-cresol methyl ether; 3-Amino-para-cresol methyl ether; 4-Methoxy-m-toluidine; 4-Methyl-2-aminoanisole; 5-Methyl-o-anisidine; C.I. Azoic Red 83; Krezidin; Krezidine; 5-Methyl-o-anisidine; p-Kresidin;

SMILES

c1(c(cc(C)cc1)N)OC

CLASSIFICATION

Anisidine, Aromatic amine

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE yellow to brown crystalline solid
MELTING POINT

50 - 52 C
BOILING POINT 235 C
SPECIFIC GRAVITY  
SOLUBILITY IN WATER

Insoluble (2810 mg/l)
SOLVENT SOLUBILITY

Soluble in most common organic solvents
AUTOIGNITION

450 C
VISCOSITY  
PH

 
VAPOR DENSITY  
log Pow 1.74 (Octanol-water)
VAPOR PRESSURE 0.025 (mmHg)
HENRY'S LAW 1.24E-07 (atm-m3/mole at 25 C)
OH RATE 2.21E-10 (cm3/molecule-sec at 25 C Atmospheric)
NFPA RATINGS Health: 2; Flammability: 1; Reactivity: 0
FLASH POINT 111 C
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & EXTERNAL LINKS
Cresidine is the trivial name for methyl anisidine or methoxy toluidine. There are three isomers, ortho-, meta-, and para-cresidine. The prefix indicate methyl group positions relative to the methoxy group on the same benzene ring. Aromatic amines Cresidine, anisidine, toluidine are all homologous to aniline, the simplest aromatic amine. Aromatic amines are the fundamental materials in the dye manufacturing industry. They are also important in the manufacture of rubber-processing chemicals, explosives, plastics, antioxidants, drugs, pesticides and other chemical compounds. Aromatic amines take part in many kinds of chemical reactions and offer many industrial applications.

 

 

 

o-Cresidine

m-Cresidine

p-Cresidine

 o-Cresidine

m-Cresidine

p-Cresidine

(CAS RN: 16452-01-0)

(CAS RN: 102-50-1)

(CAS RN: 120-71-8)

Wikipedia Linking: http://en.wikipedia.org/wiki/Cresidine

http://ntp.niehs.nih.gov/
Properties: p-Cresidine has a molecular weight of 137.2 and occurs as white crystals. It melts at 51.5°C and boils at 235°C. p-Cresidine is slightly soluble in water and chloroform and soluble in ether benzene and ethanol. Its log octanol/water partition coefficient is 1.74 (HSDB 2001).
Use: p-Cresidine is used exclusively as a synthetic chemical intermediate to produce azo dyes and pigments, such as Direct Orange 72, FD&C Red 40, and Direct Violet 9. These dyes are produced commercially in the United States and are used in the textile industry (IARC 1982,NCI 1979).
Production: p-Cresidine has been produced in the United States since 1926 (IARC 1982). The 1997 Directory of Chemical Producers named one producer of the compound, but the quantity produced was considered to be proprietary (SRI 1997). Approximately one million lb were produced in the United States in 1977 (HSDB 2001). p-Cresidine was included in the 1990 list of high production volume (HPV) chemicals, but it was not included in the 1994 list. HPV chemicals are those that are manufactured in or imported into the United States in amounts greater than or equal to one million lb (EPA 2001). Eight current U.S. suppliers were identified (Chem Sources 2001). No recent import or export data were found. According to HSDB (2001), approximately 89,000 and 590,000 lb were imported in 1977 and 1979, respectively.

http://www.inchem.org/
Material Safety Data Sheet

http://ntp.niehs.nih.gov/
p-Cresidine, used in the production of various azo dyes, was selected for bioassay by the National Cancer Institute in response to the high incidence of bladder cancer observed among dye manufacturing industry workers. Aromatic amines are one class of chemicals believed to contribute to the increased cancer risk in this industry.
A bioassay of p-cresidine for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. p-Cresidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The dietary concentrations used in the chronic bioassay for low and high dose rats were 0.5 and 1.0 percent, respectively. The time-weighted average concentrations fed to low dose male, low dose female, high dose male and high dose female mice were 0.22, 0.22. 0.46, and 0.44 percent, respectively.
SALES SPECIFICATION

APPEARANCE

yellow to brown crystalline solid
ASSAY

98.5% min
MELTING POINT

50 C

TRANSPORTATION
PACKING  
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

Hazard Symbols: T, Risk Phrases: 45-22, Safety Phrases: 53-45