the trivial name for methyl anisidine or methoxy toluidine.
There are three isomers, ortho-,
meta-, and para-cresidine. The
prefix indicate methyl group positions relative to the
methoxy group on the same benzene ring. Aromatic
amines Cresidine, anisidine, toluidine are all homologous to aniline,
the simplest aromatic amine. Aromatic
amines are the fundamental
materials in the dye manufacturing industry. They are
also important in the manufacture of
rubber-processing chemicals, explosives, plastics, antioxidants, drugs, pesticides and other
amines take part in many kinds of chemical reactions and offer many industrial
(CAS RN: 102-50-1)
p-Cresidine has a molecular weight of 137.2 and occurs
as white crystals. It melts at 51.5°C and boils
at 235°C. p-Cresidine is slightly soluble in water
and chloroform and soluble in ether benzene and ethanol.
Its log octanol/water partition coefficient is 1.74
Use: p-Cresidine is used exclusively
as a synthetic chemical intermediate to produce azo
dyes and pigments, such as Direct Orange 72, FD&C
Red 40, and Direct Violet 9. These dyes are produced
commercially in the United States and are used in the
textile industry (IARC 1982,NCI 1979).
p-Cresidine has been produced in the United States since
1926 (IARC 1982). The 1997 Directory of Chemical Producers
named one producer of the compound, but the quantity
produced was considered to be proprietary (SRI 1997).
Approximately one million lb were produced in the United
States in 1977 (HSDB 2001). p-Cresidine was included
in the 1990 list of high production volume (HPV) chemicals,
but it was not included in the 1994 list. HPV chemicals
are those that are manufactured in or imported into
the United States in amounts greater than or equal to
one million lb (EPA 2001). Eight current U.S. suppliers
were identified (Chem Sources 2001). No recent import
or export data were found. According to HSDB (2001),
approximately 89,000 and 590,000 lb were imported in
1977 and 1979, respectively.
Safety Data Sheet
p-Cresidine, used in the production of various azo dyes, was selected for
bioassay by the National Cancer Institute in response to the high incidence of
bladder cancer observed among dye manufacturing industry workers. Aromatic
amines are one class of chemicals believed to contribute to the increased cancer
risk in this industry.
A bioassay of p-cresidine for possible carcinogenicity was conducted using
Fischer 344 rats and B6C3F1 mice. p-Cresidine was
administered in the feed, at either of two concentrations, to groups of 50 male
and 50 female animals of each species. The dietary concentrations used in the
chronic bioassay for low and high dose rats were 0.5 and 1.0 percent,
respectively. The time-weighted average concentrations fed to low dose male, low
dose female, high dose male and high dose female mice were 0.22, 0.22. 0.46, and
0.44 percent, respectively.