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LAUDANOSINE |
| Synonyms. Laudanosine; 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline; (+-)-Laudanosine; -methyltetrahydropapaverine; (1)-1-((3,4-Dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline; (1S)-1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy- 2-methyl-3,4-dihydro-1H-isoquinoline; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
1699-51-0 |
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EINECS RN |
216-923-9 |
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FORMULA |
C21H27NO4 |
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MOLE WEIGHT |
357.44 |
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H.S CODE |
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SMILES |
c12[C@@H](Cc3cc(c(OC)cc3)OC)[N@@](CCc1cc(OC)c(c2)OC)C |
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CLASSIFICATION |
Tetrahydroisoquinoline, Alkaloid |
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EXTRA NOTES |
Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite[1] of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. wikipedia |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
yellow powder |
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MELTING POINT |
89 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Laudanosine Wikipedia Linking - Laudanosine Google Scholar Search - Laudanosine U.S. National Library of Medicine - Laudanosine PubChem Compound Summary - Laudanosine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Laudanosine NCBI (http://www.ncbi.nlm.nih.gov/) - Laudanosine |
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| SALES SPECIFICATION | |
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APPEARANCE |
yellow powder |
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ASSAY |
98% min |
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MELTING POINT |
87 ~ 89 C |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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