EPLERENONE

Synonyms. Eplerenone; Epoxymexrenone; nspra; Selara; 9,11alpha-Epoxy-17-hydroxy-3-oxo- 17alpha-pregn-4-ene-7alpha, 21-dicarboxylic acid gamma-lactone methyl ester; (7alpha,11alpha,17alpha)-Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo- gamma-lactone methyl ester;

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PRODUCT IDENTIFICATION

CAS RN

107724-20-9

EINECS RN

 

FORMULA

C24H30O6

MOLE WEIGHT

414049

H.S CODE

2932.20.2000

SMILES

C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5 ([C@H]3CC[@@]56CCC(=O)O6)C)C(=O)OC

CLASSIFICATION

Aldosterone Antagonist, Diuretics, Hormone, Natriuretic Agent

EXTRA NOTES

Eplerenone is a selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure. http://pubchem.ncbi.nlm.nih.gov/

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

240 ~ 242 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

very Slightly soluble

SOLVENT SOLUBILITY

Soluble in dichloromethane, acetonitrile, DMSO. Slightly soluble in ethanol, sparingly soluble in MEK, methanol.

VAPOR DENSITY

 

log P(octanol-water)

7.1

VAPOR PRESSURE

 

AUTOIGNITION TEMP

 
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 0, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Eplerenone

Wikipedia Linking - Eplerenone

Google Scholar Search - Eplerenone

U.S. National Library of Medicine - Eplerenone

PubChem Compound Summary - Eplerenone

IPCS INCHEM -  Eplerenone

Drug Bank -  Eplerenone

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Eplerenone

ChEBI (http://www.ebi.ac.uk/chebi/) -  Eplerenone

NCBI (http://www.ncbi.nlm.nih.gov/) -  Eplerenone

Material Safety Data Sheet - Eplerenone

Human Metabolome Database - Eplerenone

Hazardous Substances Data Bank - Eplerenone

EPA - Substance Registry Services - Eplerenone

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

99% min

MELTING POINT

240 ~ 242 C

OPTICAL ACTIVITY

+4° ~ +6° (in chloroform)

LOSS ON DRYING

0.5% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Not a hazardous substance.

 

PACKING

Preserve in light-resistant and well-closed containers