(R)-2-METHYLPIPERAZINE

PRODUCT IDENTIFICATION

CAS NO. 75336-86-6

(R)-2-METHYLPIPERAZINE

EINECS NO. 203-644-2
FORMULA C5H12N2
MOL WT. 100.10

H.S. CODE

 

TOXICITY

 

SYNONYMS (R)-(-)-2-Methylpiperazine;

DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystals

MELTING POINT 91 - 93 C
BOILING POINT 155 - 156 C
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions. Moisture, light sensitive.

GENERAL DESCRIPTION

Chiral piperazine derivatives, containing 6--membered diazaheterocycle enantiomeric intermediates, have become increasingly important in asymmetric synthesis in biological and pharamceutical activities. (R)-2-Methylpiperazine is important for quinoline antibiotics.
SALES SPECIFICATION

APPEARANCE

white to off-white crystals

CHEMICAL PURITY

98.0% min

OPTICAL PUIRTY

98.0% min e.e.
TRANSPORTATION
PACKING
 
HAZARD CLASS 4.1 (Packing Group: III)
UN NO. 2925
OTHER INFORMATION
Hazard Symbols: XI, F, Risk Phrases: 11-36/37/38, Safety Phrases: 16-26-36/37/39
Optical Rotation: -16.5 ±1° (C=5 in MeOH) 
GENERAL DESCRIPTION OF PIPERAZINE
Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and  poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane. Piperazine is a main moiety in psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes. Benzylpiperazine is bannaed in many countries. Benzylpiperazine  has been used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an important role in biological research and drug manufacturing industry including the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic, antiemetic and antimigraine agents. The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants.