THYMOPENTIN

THYMOPENTIN

N-(N-(N-(N2-L-Arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)-L-tyrosine; Thymopentine; Thymopentinum; Timopentina; Thymopoietin pentapeptide; Arg-Lys-Asp-Val-Tyr; Sintomodulina; Mepentil; Timunox; TP-5; (3S)-3-(((2S)-6-amino-2-(((2S)-2-amino-5-(diaminomethylideneamino) pentanoyl) amino) hexanoyl) amino)-4-(((2S)-1-(((2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-3-methyl-1- oxobutan- 2-yl)amino)-4-oxobutanoic acid;

PRODUCT IDENTIFICATION
CAS RN	69558-55-0, 177966-81-3 (acetate)
EINECS RN
FORMULA	C₃₀H₄₉N₉O₉
MOLE WEIGHT	679.76
CLASSIFICATION	Bioactive peptide / Immunoregulator

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white powder
MELTING POINT
BOILING POINT
DENSITY
SOLUBILITY IN WATER	Soluble
pH
VAPOR DENSITY
REFRACTIVE INDEX
FLASH POINT

STABILITY AND REACTIVITY
STABILITY	Stable under normal conditions.
INCOMPATIBLE MATERIALS	Strong oxidizing agents
DECOMPOSITION PRODUCTS	Carbon monoxide, Carbon dioxide, Nitrogen oxides.
POLYMERIZATION	Has not been reported
NFPA RATINGS

SAFETY
HAZARD NOTES	Target Organ Effect. Target Organs: Immune system.
EYE	May cause eye irritation.
SKIN	May be harmful if absorbed through skin. May cause skin irritation.
INGESTION	May be harmful if swallowed.
INHALATION	May be harmful if inhaled. May cause respiratory tract irritation.
CHRONIC

TRANSPORT & REGULATORY INFORMATION
UN NO.
HAZARD CLASS
PACKING GROUP
HAZARD SYMBOL
RISK PHRASES
SAFETY PHRASES

EXTERNAL LINKS & GENERAL INFORMATION

Thymopentin, also known as TP-5, is a synthesized derivative of thymopoietin, a naturally occurring hormone responsible for inducing T-cell precursors to differentiate and mature. A study at the Istituto di Patologia Medica in Bari, Italy, reported thymopentin-related increases in T4 cells and some improvement in symptoms for 21 people. Two studies of thymopentin published at the Sixth International Conference on AIDS pointed to stabilization of T-helper counts and p24 antigenemia in asymptomatic and mildly symptomatic patients during treatment with thymopentin. One of the studies was too small to see differences in disease progression. In the larger study, none of the treated patients progressed to symptoms, compared to four of the placebo patients who did progress. No side effects were attributed to thymopentin (http://www.aids.org/)

A synthetic pentapeptide which is the active site of the naturally occurring hormone thymopoietin with immunomodulating properties. Thymopentin enhances the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects. This agent also augments the effects of ionizing radiation by arresting cancer cells in the G2/M phase of the cell cycle.(http://www.cancer.gov/)

Thymopentin is a synthetic pentapeptide. It can modulate immune system. Laboratories research and clinical results both show that it normalizes the immune function in two directions (promoting or inhibiting) in various cases of derangement, whether in suppression or hypersensitivity. Thus it is emerging as an immune regulatory agent with great potential. Besides its activity in the immune system, it was discovered to reduce the content of propane dialdehyde in brain, thymus and liver, enhance the activity of SOD at the same moment of improving its content, thus eliminate the radicals in human body and reduce the level of lipid peroxides. All the above illuminate that it has affects against aging and some circulatory system diseases. (http://thymosin.net/)

SALES SPECIFICATION
APPEARANCE	white to slightly yellowish powder
IDENTIFICATION	pass (HPLC)
PURITY	98.0% min
AMINO ACID	1.0 ± 10% (each theoretical Composition)
RELATED SUBSTANCES	2.0% max (total impurity), 1.0% max (Individual impurity)
PEPTIDE CONTENT	80.0% min (N determination)
pH	7.0 ~ 9.0
WATER CONTENT	8.0% max
OPTICAL ROTATION	-14.0° ~ -22.0°
BACTERIAL ENDOTOXINS	5EU/mg max

PACKING

PRICE INFORMATION