LYPRESSIN ACETATE

LYPRESSIN ACETATE

(8-Lysine)vasopressin; 8-L-Lysine vasopressin; 8-L-Lysinevasopressin; Diapid; L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysylglycinamide cyclic (1-6)-disulfide; L-Lysine vasopressin; Lipresina; Lipressina; Lypressine; Lypressinum; Lysine pitressin; Lysine vasopressin; Lysine-vasopressin; Pitressin; Postacton; Syntopressin; Vasophysin; Vasopressin- 8-lysine; N-(6-Amino-1-((2-amino-2-oxoethyl)amino)-1-oxohexan-2-yl)-1-(16-amino-4- (2-amino-2- oxoethyl)-7- (3-amino-3-oxopropyl)-10-benzyl-13-((4-hydroxyphenyl)methyl)- 3,6,9,12,15- pentaoxo-18, 19-dithia- 2,5,8,11, 14-pentazacycloicosane-1-carbonyl)pyrrolidine-2-carboxamide;

PRODUCT IDENTIFICATION
CAS RN	50-57-7
EINECS RN	200-050-5
FORMULA	C₄₆H₆₅N₁₃O₁₂S₂
MOLE WEIGHT	1056.22
CLASSIFICATION	Bioactive peptide / Antidiuretic / Vasoconstrictor

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to slightly yellowish powder
MELTING POINT
BOILING POINT
DENSITY
SOLUBILITY IN WATER	Soluble (soluble in acetic acid at 1mg/ml)
pH
VAPOR DENSITY
REFRACTIVE INDEX
FLASH POINT

STABILITY AND REACTIVITY
STABILITY	Stable under normal conditions.
INCOMPATIBLE MATERIALS	Strong acids, Strong bases
DECOMPOSITION PRODUCTS	Carbon monoxide, Carbon dioxide, Nitrogen oxides. Sulphur oxides
POLYMERIZATION	Has not been reported
NFPA RATINGS

SAFETY
HAZARD NOTES	This substance is not listed in a priority list (as foreseen under Council Regulation (EEC) No 793/93 on the evaluation and control of the risks of existing substances.).
EYE	May cause eye irritation.
SKIN	May be harmful if absorbed through skin. May cause skin irritation.
INGESTION	May be harmful if swallowed.
INHALATION	May be harmful if inhaled. May cause respiratory tract irritation.
CHRONIC

TRANSPORT & REGULATORY INFORMATION
UN NO.
HAZARD CLASS
PACKING GROUP
HAZARD SYMBOL
RISK PHRASES
SAFETY PHRASES

EXTERNAL LINKS & GENERAL INFORMATION

Vasopressin: abbr. VP. This protein is called also Antidiuretic hormone (ADH), Adiuretin, Vasotocin, Pituitrin P and Pitressin. It is a cyclic nonapeptide (1,6 disulfide bridge) synthesized in the hypothalamus and stored in the posterior lobe of the pituitary from which it is released into the circulation as necessary. AVP has been found also in other tissues, including testis, ovary, uterus, adrenal gland, superior cervical ganglion, and thymus (Clements and Funder, 1986). The term Arginine vasopressin (Arg-Vasopressin, abbr. AVP or ARVP) refers to the presence of an arginine residue at position 8 (which can be occupied also by lysine (Lysine vasopressin, abbr. LVP); residues 3 and 4 have been shown also to be variable. Desmopressin (1-Desamino-8-D-Arginine vasopressin; abbr. DDAVP) is a synthetic analog of arginine vasopressin that is well tolerated after systemic administration. The human vasopressin gene encodes a larger protein product (termed AVP-NpII, arginine-vasopressin-neurophysin II, vasopressin-neurophysin 2-copeptin) (Sausville et al, 1985). Vasopressin is derived from exon 1 of the gene. A protein designated neurophysin or neurophysin-2 (exon 2) functions as a carrier protein (Brownstein et al, 1980). A third glycoprotein, termed copeptin, is encoded by exon 3 (Land et al, 1982; Ivell and Burbach, 1991). Mutations in the Vasopressin gene have been found in rats with hereditary diabetes insipidus (Brattleboro rats). These animals are deficient in synthesis of both arginine vasopressin and one species of neurophysin (Sunde and Sokol, 1975; Schmale et al, 1984). Mutations have been found also in human patients with familial autosomal dominant neurohypophyseal diabetes insipidus (Ito et al, 1997; Rittig et al, 1996). Ito et al (1997) have suggested that the cellular toxicity in familial neurohypophyseal diabetes insipidus may be caused by the intracellular accumulation of mutant precursor proteins. (http://www.copewithcytokines.de/)

Desmopressin (1-Desamino-8-D-Arginine vasopressin; abbr. DDAVP) is a synthetic analog of arginine vasopressin. Among other things, this compound increases the expression of factor VIII and von Willebrand factor in healthy individuals, but, unlike natural vasopressin, it has little or no effect on vasoconstriction, does not increase blood pressure, and has no effect on the contraction of the uterus or gastrointestinal tract (Cash et al, 1974; Mannucci et al, 1975) (http://www.copewithcytokines.de/)

Argipressin (also known as ADH -antidiuretic hormone and as AVP - arginine vasopressin): a structural analogue of vasopressin, having arginine at position 8. This is a human hormone and most other mammals. This hormone is mainly released when the body is low on water.

Lypressin (also known as LVP - lysine vasopressin): a very similar substance with Argipressin, in having lysine instead of arginine. This is the antidiuretic hormone of the pig family.

These hormones are stored in the posterior part of the pituitary gland to be released into the blood stream and into the brain. The synthetic preparations of these hormones are used as antidiuretics to treat central diabetes insipidus when desmopressin is too potent. They are used to improve vasomotor tone and blood pressure.

Terlipressin is an inactive prodrug progressively converted to lypressin in the body. It is not used in the treatment of diabetes insipidus but in that of digestive hemorrhages by rupture of esophageal varices because of its vasoconstrictive effect on the portal circulation. ((http://www.pharmacorama.com/)

Pharmacological Actions

Antidiuretic
Cardiovascular
Coagulant
Hematologic
Natriuretic
Vasoconstrictor

SALES SPECIFICATION
APPEARANCE	white to slightly yellowish powder
IDENTIFICATION	pass (HPLC)
PURITY	98.0% min
AMINO ACID	±10% (theoretical Composition)
RELATED SUBSTANCES	2.0% max (total impurity), 1.0% max (Individual impurity)
PEPTIDE CONTENT	80.0% min (N determination)
ACETATE CONTENT	15.0% max
WATER CONTENT	6.0% max
OPTICAL ROTATION	-72.0° ~ -82.0°(c=1, 1% HAc)
BACTERIAL ENDOTOXINS	500EU/mg max

PACKING

PRICE INFORMATION