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GONADORELIN |
| Dirigestran; Fertagyl; Follicle-stimulating hormone-releasing factor; Gonadorelina; Gonadorelinum; Gonadotropin releasing hormone; Gonadotropin, luteinizing hormone-releasing hormone; Gonadotropin-releasing factor; Gonadotropin-releasing hormone; Hypocrine; LH-Releasing factor; LH-Releasing hormone; Luforan; Lutal; Lutamin; Luteinizing hormone-releasing factor; Lutrefact; Mammalian GnRH; Mammalian LH-RH; Mammalian gonadotropin-releasing hormone; Relefact; Relisorm L; p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2; [D-Ser4]-Gonadorelin; 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide; Other CAS RNs: 9042-18-6; 9061-55-6; 9066-58-4; 38569-05-0; 71339-77-0 |
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| PRODUCT IDENTIFICATION |
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CAS RN |
33515-09-2 (parent), 51952-41-1 (HCl); 52699-48-6 (Acetate) |
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EINECS RN |
251-553-1 |
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FORMULA |
C55H75N17O13 |
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MOLE WEIGHT |
1182.29 |
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CHEMICAL FAMILY |
Polypeptide |
| CATEGORIES |
Synthetic GnRH |
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| PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE |
White to off-white powder |
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MELTING POINT |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
Soluble (Soluble in 1% acetic acid) |
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pH |
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VAPOR DENSITY |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong acids, Strong bases |
| DECOMPOSITION PRODUCTS |
Carbon monoxide, Carbon dioxide, Nitrogen oxides |
| POLYMERIZATION | Has not been reported |
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TOXICOLOGICAL |
Oral Rat: LD50: >3grams/kg |
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| SAFETY |
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HAZARD NOTES |
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EYE |
May cause eye irritation. |
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SKIN |
May cause skin irritation. May be harmful if absorbed through skin. |
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INGESTION |
May cause irritation. May be harmful if swallowed. |
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INHALATION |
May cause irritation. May be harmful if inhaled. May cause respiratory tract irritation. |
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TARGET ORGANS |
Reproductive system |
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CHRONIC |
Possible hypersensitization, skin rash, hot flushes, loss of libido, osteoporosis, vaginal dryness in women, and inhibition of sperm production in males. |
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| TRANSPORT & REGULATORY INFORMATION |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP |
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| HAZARD SYMBOL |
T |
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RISK PHRASES |
60 |
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SAFETY PHRASES |
45-36/37/39-22 |
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| EXTERNAL LINKS & GENERAL INFORMATION | |
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Wikipedia Linking: http://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone Sexual hormones are secreted by the gonades, testes and ovaries. They are steroids. Their secretion is controlled by the hypothalamic-pituitary complex which releases stimulins which are polypeptides. The hypothalamus releases several hormones, one of which is gonadorelin or GnRH (gonadotropin releasing hormone), also called LHRH (luteinizing hormone releasing hormone). GnRH is a decapeptide which controls pituitary secretion of LH (luteinizing hormone) and FSH (follicle-stimulating hormone). It i s secreted physiologically in a pulsatile way by intermittent discharges, at the frequency of approximately 0.5 to 1 discharge per hour. These discharges are elicited by a structure sometimes called the pulsatile hypothalamic generator. This secretion is modulated by transmitters, and is decreased by gonadal hormones testosterone in men, estradiol and progesterone in women. However, in women, in the middle of the menstrual cycle, it is the rise in the concentration of estradiol which elicits the release of GnRH and ovulation. GnRH released by the hypothalamus directly reaches the pituitary gland by the venous portal system. (http://www.pharmacorama.com/) The hypothalamus is a region of the brain. It contains several types of neurons responsible for secreting different hormones.
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use. (http://www.druglib.com/)
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| SALES SPECIFICATION |
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ACETATE |
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APPEARANCE |
White to off-white powder |
| IDENTIFICATION |
pass (MS, HPLC) |
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PEPTIDE CONTENT |
98.0% min |
| AMINO ACID |
Ser: 0.7 - 1.05 Glx: 0.95 - 1.05 Pro: 0.95 - 1.05 Gly: 1.9 - 2.1 Leu: 0.9 - 1.1 Tyr: 0.7 - 1.05 His: 0.95 - 1.05 Trp: Present Arg: 0.95 - 1.05 Isoleucine and Lysine absent; traces |
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RELATED SUBSTANCES |
2.0% max (total impurity), 1.0% max (Individual impurity) |
| RESIDUAL SOLVENTS |
0.1%
max
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| ACETATE |
12.5% max |
| WATER | 7.0% max |
| OPTICAL ROTATION | -54.0° ~ -66.0°(c=1, 1% HAc) |
| MICROBIOLOGICAL TESTS |
Total viable aerobic count:
300CFU/g max Bacterial endotoxins: 70IU/mg max |
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HCl |
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APPEARANCE |
White to off-white powder |
| IDENTIFICATION |
pass (MS, HPLC) |
| AMINO ACID |
Ser: 0.7 - 1.05 Glx: 0.95 - 1.05 Pro: 0.95 - 1.05 Gly: 1.9 - 2.1 Leu: 0.9 - 1.1 Tyr: 0.7 - 1.05 His: 0.95 - 1.05 Trp: 0.3 - 1.1 Arg: 0.95 - 1.05 |
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PEPTIDE CONTENT |
97.0% min |
| Chloride | 4.0 - 6.0% |
| WATER | 7.0% max |
| OPTICAL ROTATION | -57.0° ~ -63.0°(c=1, 1% water) |
| ACETATE |
1.0% max |
| RESIDUAL SOLVENTS |
0.1%
max
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| MICROBIOLOGICAL TESTS |
Total viable aerobic count:
300CFU/g max Bacterial endotoxins: 70IU/mg max |
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| PACKING |
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| PRICE INFORMATION |
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