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CALCITONIN |
| Salmon calcitonin; Thyrocalcitonin (salmon); Tonocalcin; Thyrocalcitonin; Calcimar ; Calcitonin salmon; Cibacalcin; 鲑降钙素;鲑鱼降钙素; |
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| PRODUCT IDENTIFICATION |
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CAS RN |
47931-85-1; 9007-12-9 |
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EINECS RN |
256-342-8; 232-693-2 |
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FORMULA |
C145H240N44O48S2 |
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MOLE WEIGHT |
3431.85 |
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CHEMICAL FAMILY |
Linear Polypeptide |
| CATEGORIES | Bone density conservation agent |
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| PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE |
White to off-white crystalline powder |
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MELTING POINT |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
Freely soluble |
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pH |
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VAPOR DENSITY |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions |
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INCOMPATIBLE MATERIALS |
Strong acids, Strong bases |
| DECOMPOSITION PRODUCTS |
Carbon oxides, nitrogen oxides (NOx), Sulfur oxides |
| POLYMERIZATION |
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TOXICITY |
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| SAFETY |
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HAZARD NOTES |
This substance is not classified as dangerous |
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EYE |
May cause eye irritation. In case of eye contact, flush eyes with water as a precaution. |
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SKIN |
May be harmful if absorbed through skin. May cause skin irritation. In case of skin contact, wash off with soap and plenty of water. |
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INGESTION |
May be harmful if swallowed. Never give anything by mouth to an unconscious person. Rinse mouth with water. |
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INHALATION |
May be harmful if inhaled. May cause respiratory tract irritation. If breathed in, move person into fresh air. |
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TARGET ORGANS |
Bone, Kidney |
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| TRANSPORT & REGULATORY INFORMATION |
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UN NO. |
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| HAZARD CLASS |
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| HAZARD SYMBOL |
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RISK PHRASES |
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SAFETY PHRASES |
22-24/25 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking: http://en.wikipedia.org/wiki/Calcitonin Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. In birds, fish and amphibians, calcitonin is secreted from the ultimobrachial glands. Calcitonin is a 32 amino acid peptide cleaved from a larger prohormone. It contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding CGRP; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family. (http://arbl.cvmbs.colostate.edu/) Calcitonin is used to lower high blood calcium levels in people who have cancer that is in the bones. It is also used to treat other conditions, including osteoporosis in women past menopause and Paget's disease of the bone. Multiple myeloma and some cancers that spread to the bones can break down bone materials and release large amounts of calcium into the blood. This condition, known as hypercalcemia, can be dangerous. Calcitonin is a hormone normally made by the thyroid gland. It helps keep calcium levels in the body from getting too high. It does this mainly by blocking the breakdown (absorption) of bone, which slows the release of more calcium into the blood. It also helps the kidneys rid the body of the excess calcium in the blood. It affects the intestines as well, lowering the amount of calcium entering the body through food. As a drug, calcitonin-salmon is a man-made version of the hormone as it is found in salmon (which is more potent and lasts longer than the human form). Taking the drug raises calcitonin levels in the body, which leads to lower blood calcium levels within a few hours. http://www.cancer.org/)Calcitonin is a naturally occurring hormone. It helps regulate calcium levels in your body and is involved in the process of bone building. When taken by shot or nasal spray, it slows the rate of bone thinning. It also relieves pain that occurs when the bones in the spine (vertebrae) break and collapse on top of each other (spinal compression fracture). Calcitonin is used in women with osteoporosis to reduce bone loss. It reduces spinal bone (vertebrae) fractures when taken by postmenopausal women for at least 1 year. It may be prescribed for women who are more than 5 years beyond menopause and who do not tolerate bisphosphonate medications. Calcitonin can be used in men with osteoporosis who have normal levels of the male sex hormone testosterone or whose osteoporosis does not get better with testosteron treatment. Calcitonin relieves pain caused by spinal compression fractures. (http://www.svcmc.org/)
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| SALES SPECIFICATION |
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APPEARANCE |
white to off-white crystalline powder |
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IDENTIFICATION |
Pass Test I, II (TLC, HPLC) |
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AMINO AID ANALYSIS |
Asp: 1.8 - 2.2 Glu: 2.7 - 3.3 Pro: 1.7 - 2.3 Gly: 2.7 - 3.3 Val: 0.9 - 1.1 Leu: 4.5 - 5.3 His: 0.9 - 1.1 Arg: 0.9 - 1.1 Lys: 1.8 - 2.2 Ser: 3.2 - 4.2 Thr: 4.2 - 5.2 Tyr: 0.7 - 1.1 Half-cystine: 1.4 - 2.1 |
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PEPTIDE CONTENT |
97.5% min |
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ASSAY |
90.0 - 105.0% |
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WATER |
10.0% max |
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pH |
4.9 - 5.7 (1% aq. solution) |
| HEAVY METALS | 20ppm max |
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SULFATES |
300ppm max |
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CHLORIDE |
200ppm max |
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ACETATE CONTENT |
15.0% max |
| LOSS ON DRYING |
0.5% max |
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RELATED SUBSTANCES |
Individual
impurity: 1.0% max |
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MICROBIOLOGY |
Total
viable aerobic count: 100CFU/g max |
| RESIDUAL SOLVENTS |
Ethanol 0.2% max Acetonitrile: 0.04% max Methylene chloride: 600ppm max |
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| PRICE INFORMATION |
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