TRIPTERINE (CELASTROL)

TRIPTERINE
PRODUCT IDENTIFICATION
CAS NO.	34157-83-0
EINECS NO.
FORMULA	C₂₉H₃₈O₄
MOL WT.	450.61
H.S. CODE
TOXICITY
DERIVATION
SYNONYMS	Celastrol;
(2R,4aS,6aS,6aR,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6, 13,14,14b- octahydropicene-2-carboxylic acid; (20alpha)-3-Hydroxy-2-oxo- D:A-Friedo-24- noroleana- 1(10),3,5,7- tetraen-29-oic acid; 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a, 5,6,6a,11,12b,13,14,14a,14b- tetradecahydropicene-2-carboxylic acid;
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	red crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Insoluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health Hazard: 2 Fire: 0 Reactivity Hazard:0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
GENERAL DESCRIPTION & EXTERNAL LINKS
Celastrol has been effectively used in the treatment of autoimmune diseases, asthma, chronic inflammation, and neurodegenerative disease. Under in vitro conditions, Celastrol was found to inhibit cancer cell proliferation and induce leukemic cell death; however, the molecular mechanism involved still remains unclear. (http://cancerres.aacrjournals.org/) Tripterine (celastrol) is a pentacyclic triterpenoid compound isolated from the Chinese Tripterygium wilfordii Hook. It has an activity of immunosuppressive and anti-inflammatory. Triterpenes antioxidants are not common, but tripterine's antioxidant potency is equivalent to about 15 times that of alpha-tocopherol.
SALES SPECIFICATION
APPEARANCE	red crystalline powder
PURITY	98.0% min
WATER	2.0% min
TRANSPORTATION
PACKING	III
HAZARD CLASS	6.1
UN NO.	2811
OTHER INFORMATION
`Hazard Symbols: T, Risk Phrases:25 , Safety Phrases: 45`
PRICES