TENOFOVIR DISOPROXIL FUMARATE

PRODUCT IDENTIFICATION
CAS NO. 202138-50-9
206184-49-8 (Hydrate)
147127-20-6 (parent)

TENOFOVIR DISOPROXIL FUMARATE

EINECS NO.  
FORMULA C23H34N5O14P
MOL WT. 635.51

H.S. CODE

  

TOXICITY

  
PRICE

U$3,000.- for 100gr
SYNONYMS Tenofovir disoproxil; TDF; Truvada
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl) methoxy)propyl)adenine fumarate; Tenofovir DF; 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine, fumarate; (R)-5-((2-(6-Amino-9H-purin-9-yl)-1-methylethoxy)methyl)-2,4,6,8-tetraoxa-5- phosphanonanedioic acid, bis(1-methylethyl) ester, 5-oxide, (E)-2-butenedioate

SMILES

 c12c(n(cn1)C[C@H](OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C) C)ncnc2N.C(=O)(/C=C/C(=O)O)O

CLASSIFICATION

Nucleoside analog, Microbicide, Antiretroviral

EXTRA NOTES

A class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NRTIs)

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 219 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER 13.4 mg/ml
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Tenofovir

PubChem Compound Summary - Tenofovir disoproxil fumarate

Drug Bank -  Tenofovir

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Tenofovir

http://www.ebi.ac.uk/chebi/ -  Tenofovir

http://www.ncbi.nlm.nih.gov/ -  Tenofovir

Human Metabolome Database - Tenofovir

http://www.merck.com/
Tenofovir is an antiretroviral agent that inhibits the viral enzyme reverse transcriptase and so inhibits replication of retroviruses; used as tenofovir disoproxil fumarate in the treatment of HIV-1 (human immunodeficiency virus-1) infection. Tenofovir disoproxil fumarate (TDF) is an analog of adenosine 5'-monophosphate; it interferes with the HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication. TDF is first converted intracellularly by hydrolysis to tenofovir and subsequently phosphorylated to the active tenofovir diphosphate; nucleotide reverse transcriptase inhibitor.
SALES SPECIFICATION

APPEARANCE

 white to pink crystalline

IDENTIFICATION

pass test A,B,C (UV Absorption, IR Spectrum, HPLC)

ASSAY

99.0% min

MELTING POINT

 219 C
WATER

1.0% max

HEAVY METALS

20ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
PRICE INFORMATION