FRAMYCETIN SULPHATE

PRODUCT IDENTIFICATION
CAS NO. 4146-30-9

 

EINECS NO. 223-969-3
FORMULA C23H48N6O17S
MOL WT. 712.28

H.S. CODE

  

TOXICITY

  
SYNONYMS Soframycin sulfate; Neomycin B sulfate;
(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-2- ((2S,3R,4S,5R)-4-((2S,3S,4S,5R,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl) oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl)oxy-3-hydroxycyclohexyl)oxyoxane-3,4- diol; sulfuric acid; O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6- dideoxy-beta-L- idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-D-streptamine sulfate;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Aminoglycoside is any of a group of antibiotics derived from various species of Streptomyces or Micromonosporaceae, while some of which are produced synthetically. Aminoglycosides inhibit bacterial protein synthesis by binding with the 30S ribosomal subunit. They include;

 

Aminoglycoside antibiotic

CAS RN.
Adechlorin 96328-17-5
Gentamicin 1403-66-3

Netilmicin

 56391-56-1
Gentamicin sulfate 1405-41-0
Amikacin 37517-28-5
Apramycin 37321-09-8
Butirosin sulfate anhydrous 51022-98-1
Chlorothricin 34707-92-1
Dibekacin 34493-98-6
Dihydrostreptomycin Sulfate 5490-27-7
Framycetin 119-04-0
Geneticin 49863-47-0
Hygromycin A 6379-56-2
Hygromycin B 31282-04-9
Isepamicin 58152-03-7
Kanamycin 59-01-8
Nebramycin 11048-13-8
Neomycin 1404-04-2
O-Demethylchlorothricin 134637-04-0
O-Demethylhydroxychlorothricin 134615-17-1
Paromomycin 7542-37-2

Puromycin

53-79-2
Ribostamycin 25546-65-0
Sisomicin 32385-11-8
Streptomycin 57-92-1
Streptozocin 18883-66-4
Tobramycin sulfate 49842-07-1
Tobramycin 32986-56-4

 
Neomycin is an aminoglycoside antibiotic derived from the metabolic Streptomyces fradiae, effective against a wide range of aerobic gram-negative bacilli and some gram-positive bacteria. It consists of three components A, B, and C. The main form is B, The chemical designation is 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-5-O-(3-O- (2,6-diamino-2,6-dideoxy- beta-L-idopyranosyl)-bete-D-ribofuranosyl)-D-streptamine. Neomycin is applied topically to the skin, conjunctiva, and ears in the treatment of infections due to susceptible organisms. It is used in combination with other antibiotics or antiinflammatory steroids. Neomycin sulfate is administered orally in preoperative bowel preparation. Neomycin sulfate is a white to yellowish powder; hygroscopic; very soluble in water; slightly soluble in alcohol; insoluble in acetone.

Neomycin and Framycetin are not absorbed from the gastrointestinal tract and are thusfound in many topical medications such as creams, ointments and eyedrops. They can also be used for gastrointestinal infections. Framycetin yields neamine and neobiosamine B on hydrolysis.

Neomycin analogues or derivatives;

Product

CAS RN.

Neomycin C

66-86-4
Framycetin 119-04-0

Fradicin

 1403-61-8
Neomycin 1404-04-2
Bacitracin 1405-87-4
Neomycin sulfate 1405-10-3
Neomycin, hydrochloride 1406-02-6
Neomycin undecylenate 1406-04-8
Streptonigrin 3930-19-6
Neamine 3947-65-7
Paromomycin 7542-37-2
Predni aquos opthiole 8024-67-7

Cortisporin

 8024-64-4
Synalar N 8025-20-5
Nebacetin 8025-63-6

Cicatrin

8055-43-4
Mixture (neomycin, polymyxin, bacitracin) 8057-37-2
Neoterramycin 8057-00-9

Proctosedyl

 8058-05-7

Vibrocil

 8059-14-1
Pimafucort 8072-88-6
Hexasalicylideneneomycin 11041-92-2
Neomycin B hydrochloride 25389-99-5

Ribostamycin

25546-65-0
Neomycin B sulfate 28002-70-2

3'-O-Methylneamine

 37085-86-2

4'-O-Methylneamine

 37085-87-3

1-N-(s)-4-Amino-2-hydroxybutyryl-3'4'-deoxyneamine

42859-94-9
Butirosamine 50474-68-5
Mixture (neomycin, polymyxin) 51273-62-2
Statrol 51484-67-4
Neomycin F 51795-47-2
Polyspectrin 52218-57-2
Diaropect 52503-65-8
Betnovate-N 53262-69-4
Neomycin B-glucoside 53861-54-4
L-N(sup 1)-(4-Amino-2-hydroxybutyryl)-4'-deoxyneomycin A 54333-80-1
4'-Deoxy-5-O-xylosylneamine 54333-81-2
Neomycin palmitate 55298-68-5

Ribosylparomamine

 55781-25-4
Dodeca-N-methylneomycin hexamethochloride 57270-93-6
Dimethylaminopropylneomycin 57285-81-1

Tresaderm

57571-74-1
Kanamycin phosphotransferase II 58943-39-8
Neomycin C hydrochloride 63121-20-0
Neomycin 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid 71750-54-4
Cysto-myacyne 76391-80-5
Dontisolon 76403-99-1

Framycort

 77536-65-3
Neomycin-pantothenate 78149-94-7
Vineomycin A1 78164-00-8

neomedrol-veriderm

 78232-14-1
Neo-medrol 78232-16-3

Oterna

 78371-70-7

Pulpomixine

78515-94-3

6'''-Deamino-6'''-hydroxyparomomycin I

78524-72-8
6'''-Deamino-6'''-hydroxyneomycin B 78524-73-9

Maxitrol

78666-15-6
Mixture(neomycin, nystatin, polymyxin, acetarsol, dimethicone) 78891-94-8

Sofradex

 79173-16-3

3',4'-dideoxyparomomycin

 80451-74-7
Vineomycin B2 80928-52-5
Vineomycin B1 81457-63-8
Vineomycin A2 81457-62-7
Trofodermin 84057-92-1

Dansylparomomycin

 85166-09-2
Neotil 85883-86-9
Panotile 99401-18-0

3-N-methylparomomycin I

 106288-50-0

Polyspectran OS

 117733-87-6
Mixture(colistin sulfate, neomycin sulfate, hydrocortisone acetate, thonzonium bromide) 119509-48-7
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione neomycin sulfate / polymyxin sulfate 123354-95-0
Fokalmin 126663-41-0
Dexapolyspectran 143305-95-7
SALES SPECIFICATION

APPEARANCE

 white to yellowish powder
ASSAY

630 μm/mg min (Anhydrous potency)
90.0~100.0% (HPLC)

IDENTIFICATION

positive  (Test A, Test B,)

SULFATE

 27.0 - 31.0%

pH

 6.0 - 7.0

RELATED SUBSTANCES

 Neomycin C: 3.0% max
Neamine : 1.0% max
Total Impurity: 3.0% max

LOSS ON DRYING

8.0% max

OPTICAL ROTATION

+52.5º  ~ +55.0º

SULFATED ASH

1.0% max

PARTICLE SIZE

< 25 μm (90.0% min)
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION