EPIRUBICIN HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO. 56420-45-2, 57918-25-9 (parent)
56390-09-1 (hydrochloride)

EPIRUBICIN HYDROCHLORIDE

EINECS NO. 260-145-2
FORMULA C27H29NO11·HCl
MOL WT. 579.15

H.S. CODE

  

TOXICITY

  

CLASSIFICATION

 
SYNONYMS Farmorubicin; Ellence;
(1S,3S)-3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12- trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside hydrochloride; 4'-Epidoxorubicin hydrochloride; 4'-epi-Adriamycin hydrochloride; Epidoxorubicin hydrochloride; Epirubicin HCl; Epirubicin hydrochloride; Farmorubicin; Pharmorubicin; (8S-cis)-10-((3-Amino-2,3,6-trideoxy-alpha-L- arabino-hexopyranosyl)oxy)- 7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxynaphthacene-5,12-dione hydrochloride; (8S-cis)-10-((3-Amino-2,3,6- trideoxy-alpha-L-arabino- hexopyranosyl)oxy)-7,8,9,10- tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1- methoxy-5,12-naphthacenedione hydrochloride;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE orange to red powder
MELTING POINT  
BOILING POINT

 

RELATIVE DENSITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS
Anthracycline: a class of chemotherapy drugs that are also antibiotics having a four-ring nucleus (tetrahydrotetrahydrotetracenedione.) to which is attached by aminoglycoside linkage including daunosamine (CAS 26548-47-0), isolated from the fungus Streptomyces peucetius or S. coeruleorubidus. The molecule is amphoteric. The ring-system nucleus is lipophilic, but abundant hydroxyl groups at the saturated end of the ring system is hydrophilic. The molecule contains acidic function in the ring phenolic groups as well as a basic function in the amino group in glycoside. Anthracyclines act to terminate cancer cells function by DNA intercalation, metal ion chelation, and the generation of free radicals. They are used to treat a wide range of cancers including leukemia and other neoplasms.

Epirubicin, an anthracycline cytotoxic agent, is the 4'-epi-isomer of doxorubicin, It has the same actions as doxorubicin, but has different spatial orientation of the hydroxyl group at the 4' carbon of the sugar, which features fewer side-effects and lower toxicity. The IUPAC name is (7S,9S)-7-[(2S,4S,5R,6S)-4- amino-5- hydroxy- 6-methyloxan-2-yl]oxy- 6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4 -methoxy-8,10-dihydro- 7H-tetracene- 5,12-dione.

Anthracycline

CAS RN.

eta-Isorhodomycinone

477-53-2
Rhodomycin 1401-16-7
Nogalamycin 1404-15-5
Retamycin 11130-68-0
Beromycin, anthracycline 12674-15-6
Requinomycin 12770-40-0
Daunorubicin 20830-81-3
Rhodomycinone 21288-60-8
Doxorubicin 23214-92-8
Doxorubicin hydrochloride 25316-40-9
Daunosamine 26548-47-0
Pillaromycin A 30361-37-6
Carminomycin 39472-31-6
Carubicin 50935-04-1
Cosmomycin C 55945-22-7
Epirubicin 56420-45-2
Aclarubicin 57576-44-0
Idarubicin 58957-92-9
Bohemic acid complex 64296-23-7
Menogaril 71628-96-1
Pirarubicin 72496-41-4
Iremycin 75634-51-4
Cosmomycin B 77517-27-2
Sulfurmycinone 78173-88-3
Auramycinone 78173-89-4
Sulfurmycin A 78173-90-7
Auramycin B 78173-91-8
Auramycin A 78173-92-9
Sulfurmycin B 78193-30-3
Rubeomycin B 78366-46-8
2-Hydroxyaklavinone 79008-78-9
Roseorubicins 79392-32-8
Taurimycin 79819-02-6
2-Hydroxyaclacinomycin B 85819-82-5
Anthrapyrazole 91440-30-1
Annamycin 92689-49-1
Cosmomycin B' 103470-57-1
Cosmomycin A' 103470-58-2
Oxaunomycin 105615-58-5
Viriplanin A 106153-36-0
Moflomycin 107430-03-5
Barminomycin II 108089-33-4
Barminomycin I 108147-17-7
Nemorubicin 108852-90-0
Amrubicin hydrochloride 110311-30-3
2-Pyrrolinodoxorubicin 175795-76-3
SALES SPECIFICATION

APPEARANCE

 orange to red powder

IDENTIFICATION

to pass test IR

ASSAY

97.0 - 102.0%
SPECIFIC ROTATION +310° ~ +340°

HEAVY METALS

10ppm max
RESIDUE ON IGNITION

0.1% max
pH

4.0 - 5.5
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.

 

PRICE INFORMATION

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