DOXORUBICIN HYDROCHLORIDE

DOXORUBICIN HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO.

23214-92-8 (parent)
25316-40-9 (hydrochloride)

DOXORUBICIN HYDROCHLORIDE

EINECS NO.

246-818-3

FORMULA

C₂₇H₃₀ClNO₁₁

MOL WT.

579.98

H.S. CODE

TOXICITY

CLASSIFICATION

SYNONYMS

Adriblastina; Adriblastina;

(8S,10S)-10-((3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-glycoloyl- 7,8,9,10-tetrahydro-6,8,11- trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride; Adriamycin hydrochloride; ADM hydrochloride; Adriacin; Adriamycin; Adriamycin PFS; Adriamycin RDF; Adriblastin; Doxil; Lipodox; Rubex; Caelyx; (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6 -methyloxan-2-yl]oxy-6,9,11 -trihydroxy-9-(2- hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene- 5,12-dione hydrochloride; Hydroxydaunorubicin hydrochloride;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

orange to red powder

MELTING POINT

BOILING POINT

RELATIVE DENSITY

SOLUBILITY IN WATER

VAPOR DENSITY

REFRACTIVE INDEX

NFPA RATINGS

AUTOIGNITION

FLASH POINT

STABILITY

Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Anthracycline: a class of chemotherapy drugs that are also antibiotics having a four-ring nucleus (tetrahydrotetrahydrotetracenedione.) to which is attached by aminoglycoside linkage including daunosamine (CAS 26548-47-0), isolated from the fungus Streptomyces peucetius or S. coeruleorubidus. The molecule is amphoteric. The ring-system nucleus is lipophilic, but abundant hydroxyl groups at the saturated end of the ring system is hydrophilic. The molecule contains acidic function in the ring phenolic groups as well as a basic function in the amino group in glycoside. Anthracyclines act to terminate cancer cells function by DNA intercalation, metal ion chelation, and the generation of free radicals. They are used to treat a wide range of cancers including leukemia and other neoplasms. Doxorubicin is a hydroxyl form of daunomycin in structure for the reduction in cardiotoxicity. Doxorubicin hydrochloride form of red-orange powder. It is an inhibitor of reverse transcriptase and RNA polymerase. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles in the sequestration of drugs and its implication in drug resistant phenotypes The IUPAC name is (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11 -trihydroxy-9-(2- hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione.

Anthracycline	CAS RN.
eta-Isorhodomycinone	477-53-2
Rhodomycin	1401-16-7
Nogalamycin	1404-15-5
Retamycin	11130-68-0
Beromycin, anthracycline	12674-15-6
Requinomycin	12770-40-0
Daunorubicin	20830-81-3
Rhodomycinone	21288-60-8
Doxorubicin	23214-92-8
Doxorubicin hydrochloride	25316-40-9
Daunosamine	26548-47-0
Pillaromycin A	30361-37-6
Carminomycin	39472-31-6
Carubicin	50935-04-1
Cosmomycin C	55945-22-7
Epirubicin	56420-45-2
Aclarubicin	57576-44-0
Idarubicin	58957-92-9
Bohemic acid complex	64296-23-7
Menogaril	71628-96-1
Pirarubicin	72496-41-4
Iremycin	75634-51-4
Cosmomycin B	77517-27-2
Sulfurmycinone	78173-88-3
Auramycinone	78173-89-4
Sulfurmycin A	78173-90-7
Auramycin B	78173-91-8
Auramycin A	78173-92-9
Sulfurmycin B	78193-30-3
Rubeomycin B	78366-46-8
2-Hydroxyaklavinone	79008-78-9
Roseorubicins	79392-32-8
Taurimycin	79819-02-6
2-Hydroxyaclacinomycin B	85819-82-5
Anthrapyrazole	91440-30-1
Annamycin	92689-49-1
Cosmomycin B'	103470-57-1
Cosmomycin A'	103470-58-2
Oxaunomycin	105615-58-5
Viriplanin A	106153-36-0
Moflomycin	107430-03-5
Barminomycin II	108089-33-4
Barminomycin I	108147-17-7
Nemorubicin	108852-90-0
Amrubicin hydrochloride	110311-30-3
2-Pyrrolinodoxorubicin	175795-76-3

SALES SPECIFICATION (USP30)

APPEARANCE

orange to red powder

IDENTIFICATION

to pass test IR

ASSAY

98.5 - 100.5%

RELATED MATTERS

2.0% max

HEAVY METALS

10ppm max

RESIDUE ON IGNITION

0.1% max

4.5 - 5.0

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

DOXORUBICIN MOLECULES

Chemical Name	CAS RN.
Doxorubicin	23214-92-8
Adriamycin aglycone	24385-10-2
Doxorubicin hydrochloride	25316-40-9
N-Trifluoroacetyladriamycin	26295-56-7
14-O-Acetyldoxorubicin	30489-04-4
7-Deoxyadriamycinol aglycone	37818-13-6
7-Deoxyadriamycin aglycone	38554-25-5
Adriamycin 14-octanoate, hydrochloride	51898-39-6
Doxorubicinol	54193-28-1
Valrubicin	56124-62-0
4'-Deoxydoxorubicinol 7-deoxyaglycone	56149-23-6
Epirubicin hydrochloride	56390-09-1
Epirubicin	56420-45-2
Doxorubicin, beta anomer	57819-79-1
Esorubicin	63521-85-7
Esorubicin hydrochloride	63950-06-1
Medorubicin	64314-52-9
4-Demethoxyadriamycin hydrochloride	64363-63-9
Quelamycin	64719-39-7
7,8-Dehydro-9,10-desacetyldoxorubicinone	64845-67-6
Detorubicin	66211-92-5
N,N-Dimethyldoxorubicin	70222-95-6
Leurubicin	70774-25-3
11-Deoxyadriamycin	71800-89-0
Pirarubicin	72496-41-4
3'-Deamino-3'-hydroxydoxorubicin	73113-90-3
3'-Acetoxy-4'-O-acetyldoxorubicin	73113-92-5
13-Dihydro-4'-epidoxorubicin	76155-56-1
Adriamycin octanoylhydrazone	76634-98-5
4'-O-Methyldoxorubicin	77121-90-5
4-Demethoxy-11-deoxyadriamycin	77312-69-7
5-Iminodoxorubicin	77331-69-2
Morpholinyl doxorubicin	80790-68-7
9,10-Anhydroadriamycin	80996-23-2
4-O-Demethyl-11-deoxydoxorubicin	81382-05-0
Iododoxorubicin	83997-75-5
9-Deoxydoxorubicin	84519-42-6
4-Demethoxydoxorubicinone	86333-80-4
4-Demethoxy-4'-O-methyldoxorubicin	87471-33-8
3'-Deamino-3'-(3-cyano-4-morpholinyl)doxorubicin	88254-07-3
4-Demethoxy-3'-deamino-3'-hydroxy-4'-deoxy-4'-epiadriamycin	89113-41-7
Morpholinodoxorubicin	89196-04-3
4'-Deoxydoxorubicinol	89780-72-3
Annamycin	92689-49-1
4-Demethyl-6-deoxydoxorubicin	96597-11-4
4-Demethyl-6-O-methyldoxorubicin	97777-78-1
Cyanomethyladriamycin	103450-92-6
N-(2-Hydroxyethyl)doxorubicin	103851-20-3
N,N-Di-(n-butyl)adriamycin-14-valerate	105192-72-1
4'-Amino-3'-hydroxydoxorubicin	106492-47-1
cis-(Platinum-dichloro(doxorubicin)(tert-butylamine))	107283-77-2
Nemorubicin	108852-90-0
Doxorubicin citrate	111266-55-8
4'-Iodo-4'-deoxydoxorubicinol	111865-30-6
Aconityldoxorubicin	114390-31-7
7-Deoxy-13-dihydroadriamycinone	116455-20-0
Doxorubicin-gamma-cyclodextrin complex	119227-88-2
3'-Desamino-3'-dimethylformamidinedoxorubicin	119864-31-2
3'-Desamino-3'-dimethylformamidinedoxorubicin hydrochloride	119943-52-1
Doxorubicin-N-4-hydroxyphenoxyacetamide	131089-08-2
3'-Deamino-3'-(2-methoxy-4-morpholinyl)doxorubicin	136520-72-4
N-(5,5-Diacetoxypentyl)doxorubicin	138967-27-8
13-Dihydrodoxorubicin	141434-67-5
N-(3-Pyridylmethyl)adriamycin	145785-62-2
N-(3-Pyridylmethyl)dihydroepidoxorubicin	145785-63-3
N,N-Bis(3-pyridylmethyl)adriamycin	145785-64-4
N-(3-Pyridylmethyl)epidoxorubicin	145843-38-5
Doxorubicin(6-maleimidocaproyl)hydrazone	151038-96-9
Poly(N-(2-hydroxypropyl)methacrylamide, doxorubicin)	171714-74-2
2-Pyrrolinodoxorubicin	175795-76-3
Doxorubicin-iron(III)	342653-01-4

PRICE INFORMATION