PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

off white to pale yellow powder

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

"Cefpirome is a bactericidal β-lactamase-stable cephalosporin antibiotic. As a β-lactam, it acts by disturbing the synthesis of the main bacterial cell-wall polymer, peptidoglycan. It is bactericidal at low concentrations against an extremely broad spectrum of gram-negative and gram-positive pathogens because it penetrates the cell wall of bacteria extremely rapidly and binds to the target enzymes (penicillin-binding proteins) with high affinity. Cefpirome is very stable against hydrolysis by broad spectrum plasmid-mediated and chromosomally-mediated β-lactamases and compared to third generation cephalosporins, has a lower affinity for these enzymes and is less likely to select active hyper producer mutants. Furthermore cefpirome is more active against de-repressed mutants producing high level of cephalosporinase than third generation cephalosporins. Cefpirome shows synergistic activity with aminoglycosides against many bacteria." source: http://www.medsafe.govt.nz/profs/Datasheet/discontinued/Cefrominj.htm

APPEARANCE

off white to pale yellow powder

CEFPIROME CONTENT

67.5% - 75.0%

LOSS ON DRYING

2.5% max

ASSAY

82.5% min (on anhydrous basis)